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"Name": "Storage Conditions (Product)",
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"Value": "TRAcP (9C5) Mouse Monoclonal Primary Antibody is intended for laboratory use in the detection of the TRAcP glycoprotein in formalin-fixed, paraffin-embedded tissue stained on VENTANA BenchMark IHC/ISH instruments. This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls. This antibody is intended for
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"Value": "The type-5 tartrate resistant acid phosphatase (TRAcP) is an iron-binding glycoprotein that exists in humans as distinct unprocessed and processed isoforms, 5a and 5b, respectively. TRAcP is principally expressed in cells of the monocyte lineage, including macrophages, dendritic cells, and osteoclasts, with its most well understood function being in facilitating the bone resorption process.
1 A variety of hematological disorders display TRAcP activity but antibodies developed against the protein have a particularly high sensitivity and specificity for labeling hairy cells in patient cases of hairy cell leukemia.
2-4 Anti-TRAcP has immunohistochemical utility in providing adjunctive information for the identification of hairy cell leukemia.
1. Janckila, AJ, et al. Biology and clinical significance of tartrate-resistant acid phosphatases: new perspectives on an old enzyme. Calcif Tissue Int. 2009; 85:465-83.
2. Hayman AR. Tartrate-resistant acid phosphatase (TRAP) and the osteoclast/immune cell dichotomy. Autoimmunity. 2008; 41:218-23.
3. Hoyer, JD, et al. Immunohistochemical demonstration of acid phosphatase isoenzyme 5 (tartrate-resistant) in paraffin sections of hairy cell leukemia and other hematologic disorders. Am J Clin Pathol. 1997; 108:308-15.
4. Janckila, AJ, et al. Hairy cell identification by immunohistochemistry of tartrate-resistant acid phosphatase. Blood. 1995; 85:2839-44.",
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