Real time PCR kit for qualitative detection of human Herpes Simplex Virus 1/2 and Varicella Zoster Virus.
For use with the cobas® omni utility channel on the cobas® 6800/8800 Systems.

IVD For in vitro diagnostic use.
Aid in the diagnosis of herpes infections

Herpes simplex virus 1 (HSV-1), Herpes simplex virus 2 (HSV-2) and Varicella Zoster virus (VZV) are ubiquitous yet important human pathogens that can have very similar and wide-ranging clinical presentations.1 Amongst those more susceptible for significant disease are transplant recipients and immunocompromised patients.

HSV is the second most common cause of viral infection after transplantation, whereas VZV has been shown to cause symptomatic infections in up to 20% of solid organ transplants and more than 40% hematopoietic stem cell transplants.2 Rapid and accurate laboratory confirmation of HSV-1, HSV-2 and VZV infection can be an important clinical resource for the management of transplant patients.3

Real-time PCR kit for detection of HSV-1, HSV-2 and VZV. UC-TIB-HSV/VZV is an in vitro nucleic acid amplification test for the qualitative detection of human HSV-1, HSV-2 and VZV DNA in human EDTA plasma samples to aid in the diagnosis of human HSV and VZV infections such as in transplanted and immunocompromised patients. This test utilizes the cobas® omni utility channel functionality of the cobas® 6800/8800 Systems.

Benefits of the UC-TIB-HSV/VZV (Herpes Simplex Virus and Varicella Zoster Virus Test)

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Simultaneous detection and differentiation of HSV-1, HSV-2 and VZV infections to support management of transplant or immunocompromised patients. 

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Specifically designed and optimized for use on the cobas® 6800/8800 Systems to enable menu testing consolidation and sample-to-result automation. 

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Simplicity & efficiency

Reducing variability and complexity in testing offers an alternative to lab-developed tests (LDTs), thereby reducing workload and alleviating potential risk of error for laboratories. 

Performance summary

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Performance summary

Conserved assay targets UL5 gene UL30 gene ORF-31 gene
Sample type EDTA Plasma
Minimum amount of sample required 350 μL
Sample processing volume 200 μL
Analytical sensitivity (LoD) 56.5 c/mL 67.7 c/mL 75.1 c/mL
Specificity 100 %
Kit stability 90 days with 40 re-uses
LoD: Limit of Detection


  1. Wong AA, Pabbaraju K, Wong S, Tellier R. Development of a multiplex real-time PCR for the simultaneous detection of herpes simplex and varicella zoster viruses in cerebrospinal fluid and lesion swab specimens. J Virol Methods. 2016;229:16-23. doi:10.1016/j.jviromet.2015.12.009
  2. Shiley K, Blumberg E. Herpes viruses in transplant recipients: HSV, VZV, human herpes viruses, and EBV. Infect Dis Clin North Am. 2010;24(2):373-393. doi:10.1016/j.idc.2010.01.003
  3. Fan F, Day S, Lu X, Tang YW. Laboratory diagnosis of HSV and varicella zoster virus infections. Future Virology. 2014 9(8):721-731. doi:10.2217/fvl.14.61
  4. UC-TIB-HSV/VZV Real time PCR kit for qualitative detection of human Herpes Simplex Virus 1/2 and Varicella Zoster Virus for use with the cobas® omni utility channel on the cobas® 6800/8800 Systems, 2023 (Package Insert). 



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