Herpes simplex virus 1 (HSV-1), Herpes simplex virus 2 (HSV-2) and Varicella Zoster virus (VZV) are ubiquitous yet important human pathogens that can have very similar and wide-ranging clinical presentations.1 Amongst those more susceptible for significant disease are transplant recipients and immunocompromised patients.
HSV is the second most common cause of viral infection after transplantation, whereas VZV has been shown to cause symptomatic infections in up to 20% of solid organ transplants and more than 40% hematopoietic stem cell transplants.2 Rapid and accurate laboratory confirmation of HSV-1, HSV-2 and VZV infection can be an important clinical resource for the management of transplant patients.3
Real-time PCR kit for detection of HSV-1, HSV-2 and VZV. UC-TIB-HSV/VZV is an in vitro nucleic acid amplification test for the qualitative detection of human HSV-1, HSV-2 and VZV DNA in human EDTA plasma samples to aid in the diagnosis of human HSV and VZV infections such as in transplanted and immunocompromised patients. This test utilizes the cobas® omni utility channel functionality of the cobas® 6800/8800 Systems.
Simultaneous detection and differentiation of HSV-1, HSV-2 and VZV infections to support management of transplant or immunocompromised patients.
Specifically designed and optimized for use on the cobas® 6800/8800 Systems to enable menu testing consolidation and sample-to-result automation.
Reducing variability and complexity in testing offers an alternative to lab-developed tests (LDTs), thereby reducing workload and alleviating potential risk of error for laboratories.
| HSV-1 | HSV-2 | VZV | |
| Conserved assay targets | UL5 gene | UL30 gene | ORF-31 gene |
| Sample type | EDTA Plasma | ||
| Minimum amount of sample required | 350 μL | ||
| Sample processing volume | 200 μL | ||
| Analytical sensitivity (LoD) | 56.5 c/mL | 67.7 c/mL | 75.1 c/mL |
| Specificity | 100 % | ||
| Kit stability | 90 days with 40 re-uses | ||
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