VENTANA® Kappa and Lambda Dual ISH mRNA Probe Cocktail

CE-IVD
IVD For in vitro diagnostic use.
VENTANA<sup>®</sup> Kappa and Lambda Dual ISH mRNA Probe Cocktail
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An ultra-sensitive Kappa and Lambda multiplex ISH assay to aid in the diagnosis of all B-cell lymphomas and plasma cell neoplasms

The VENTANA® Kappa and Lambda Dual ISH mRNA Probe Cocktail is a dual-color assay that enables clonality assessment in all B-cell lymphoma subtypes and plasma cell neoplasms. An innovative assay that offers unparalleled sensitivity and specificity for assessing Kappa and Lambda light chains across all B-cell lymphoma subtypes. Unlike current IHC, single ISH, and flow cytometry methods, this innovative assay provides a superior diagnostic option B-cell lymphoma diagnosis.1

Roche offers an extensive Heme portfolio with more than 60 ready-to-use markers that are optimised for use on our BenchMark instruments.5 With the launch of VENTANA Kappa and Lambda Dual ISH, Roche demonstrates its commitment to invest in innovative technology that advances science in the hematopathology space and improves patient care.

Benefits at a glance

Benefits at a glance

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Improved technology ensures highly sensitive detection of Kappa and Lambda light chains compared to some existing IVD, ISH, or IHC.2

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Capable of assessing Kappa and Lambda clonality in all B-cell lymphoma subtypes, not just multiple myeloma.2

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Suitable for use with formalin-fixed samples, overcoming the limitations of flow cytometry.2

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Two-color staining allows for Kappa and Lambda to be evaluated on the same slide, making interpretation easier and quicker, and saving tissue slides.2

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Reduces non-specific background staining commonly seen with traditional IHC and single-color ISH methods.2

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Testimonials

An expert’s perspective
An expert’s perspective

The VENTANA Kappa and Lambda Dual ISH mRNA Probe Cocktail is a quality, sensitive, and reproducible method for assessing B-cell clonality. Discover the impact of this technique on the diagnosis of lymphoma.

The VENTANA Kappa and Lambda Dual ISH mRNA Probe Cocktail is a quality, sensitive, and reproducible method for assessing B-cell clonality. Discover the impact of this technique on the diagnosis of lymphoma.
A pathologist’s perspective
A pathologist’s perspective

Hear how dual staining with the VENTANA Kappa and Lambda Dual ISH mRNA Probe Cocktail improves the detection of monoclonality for clearer interpretation by pathologists.

Hear how dual staining with the VENTANA Kappa and Lambda Dual ISH mRNA Probe Cocktail improves the detection of monoclonality for clearer interpretation by pathologists.
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        References

        1. F. Hoffmann La Roche Ltd. VENTANA Kappa and Lambda Dual ISH mRNA Probe Cocktail Method Sheet. (v C). 2025.
        2. Rimsza LM, et al. Kappa and Lambda light chain mRNA in situ hybridization compared to flow cytometry and immunohistochemistry in B cell lymphomas. Diagn Pathol. 2014;9:144.
        3. F. Hoffmann La Roche Ltd. Pathology Lab Catalog. [Internet; cited 2024 Apr 15]. Available from: https://diagnostics.roche.com/global/en/products/product category/anatomical pathology.html
        4. Sen A, Gupta D, Jagani R. Rapid in situ hybridization and immunohistochemistry: a pilot comparative study of two rapid diagnostic techniques for establishing monoclonality in plasma cell dyscrasias. Med J Armed Forces India. 2020 Jan;76(1):103-108.
        5. F. Hoffmann La Roche Ltd. IHC Menu. 2025.