Biomarkers in sepsis
There is considerable unmet medical need in sepsis, and biomarkers may have an important clinical role to play.
Biomarkers can indicate the presence of sepsis, differentiate bacterial from viral or fungal infection, differentiate local from systemic infection, stratify severity of sepsis, may help to guide antibiotic therapy, provide prognostic information, evaluate response to therapy, predict septic complications and predict the development of organ dysfunction. However, the exact role of biomarkers is yet to be defined.1
Unmet medical needs in the management of sepsis and suspected sepsis:
- Diagnosis and differential diagnosis of infection1
- Recognition and stratification of severity of sepsis1
- Early and appropriate decision regarding antibiotic therapy decisions5,8