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Nucleic acid testing (NAT)

A comprehensive portfolio of solutions to streamline operations, reduce manual tasks, and increase efficiency and quality for donor screening facilities.


Lab technician sorting blood samples for screening

Roche nucleic acid testing solutions: Efficiency and quality for labs of all sizes

Over 60 million blood and plasma donations are tested on Roche nucleic acid testing systems each day.1 From launching the first nucleic acid testing assays for blood screening, Roche has consistently remained at the forefront of keeping the blood supply safe through active surveillance of emerging infections and rapid development of screening solutions.

Roche nucleic acid testing instruments, assays, and reagents have been developed using the gold standard real-time Polymerase Chain Reaction (PCR) technology, a very sensitive technology that detects DNA and RNA molecules of infectious agents such as human immunodeficiency virus (HIV), hepatitis C virus (HCV), and hepatitis B virus (HBV) at an early stage of an infection. Easily integrated into pre- and post-analytic solutions, our instruments enable donor screening facilities to automate operations, boost throughput, and achieve quicker turnaround times, leading to greater overall workflow efficiency.

Roche's state-of-the-art nucleic acid testing assays provide comprehensive genotype coverage and excellent sensitivity, working together with analyzers that provide efficient workflows and deliver fast results. Roche’s leading molecular diagnostic solutions provide predictable operational outcomes for laboratories and help reduce the risk of disease transmission and adverse health effects in patients.

Benefits of NAT solutions from Roche

Improve blood and/or plasma supply safety

Ensure the highest level of blood safety screening and testing with:

  • Comprehensive genotype coverage, for ensuring reliable detection and safe blood supply
  • Increased protection with NAT screening from transfusion-transmitted infection(s) for recipients of donated blood or blood products
  • Real-time PCR NAT blood tests for the direct detection or quantitation of bloodborne infectious agents or infectious agent(s)
  • Highly sensitive and specific NAT testing for blood donors for less retesting and minimized loss of donors and donations

Generate trusted, reproducible results with enhanced performance

High-quality  assay management and analysis, including:

  • Proven real-time PCR technology for ensuring reliable results
  • Automated sample handling solutions and user-friendly interface for reduction in manual handling errors
  • Full-process internal control helps ensure result integrity
  • Real-time detection and discrimination of viral targets
  • True external positive controls that have no direct effect on calibration with assay control kits

Absolute automation to drive increased efficiency with minimal human interactions

Consistent, accurate and reliable testing solutions leveraging the benefits of:

  • Automated analyzers and workflow for reducing cross contamination and providing up to 8 hours walk-away time leading to overall workflow efficiency
  • Data management options for simplified order and result handling
  • Stabilized real-time PCR reagents do not require calibration
  • Ready-to-use reagents do not require thawing, mixing, or pouring
  • Flexibility to run simultaneously with other assays on the cobas® 5800*/6800/8800 Systems
  • Radio-frequency identification (RFID) and barcodes ensure full traceability from sample-in to results-out
  • Flexibility to choose the pool size that best meets your needs: individual donor testing (IDT), pools of 6, pools of 24, or pools of 96

Explore Roche NAT blood tests* and analyzers for donor screening

A comprehensive NAT menu for blood and plasma screening, including:

  • cobas® MPX: Detects and discriminates the most critical viral targets in one easy-to-use assay for HIV-1 Group M, HIV-1 Group O, HIV-2, HCV and HBV. Enables donor screening laboratories to reliably test for 3 viruses and 5 critical viral targets with a single assay, boosting operational efficiency by eliminating the need for additional discriminatory testing
  • cobas® WNV: Directly detect West Nile Virus RNA in human plasma early in the infection lifecycle for both WNV lineages 1 and 2
  • cobas® Malaria: A qualitative in-vitro nucleic acid test for the direct detection of Plasmodium DNA and RNA in whole blood samples
  • cobas® DPX**: Precise quantitation of B19V DNA and high sensitivity for HAV RNA for detecting B19V genotypes 1, 2, and 3, and hepatitis A genotypes I, II and III. Also utilizes a World Health Organization (WHO) traceable international standard to provide quantitative results for B19V
  • cobas® Babesia: Roche's first whole blood PCR test for blood screening that detects 4 species of Babesia (B. microti, B. duncani, B. divergents, B venatorum) that cause disease in humans.
  • cobas® Zika: US FDA Approved donor screening test for Zika virus, detects Asian and African strains of Zika virus with a proven high clinical sensitivity track record during the outbreak in the Americas.
  • cobas® CHIKV/DENV: A qualitative in-vitro test for the direct detection of chikungunya virus (CHIKV) RNA and dengue virus (DENV) serotypes 1-4 CHIKV WA, CHIKV ECSA, CHIKV Asian RNA in human plasma
  • cobas® HEV: Detects emerging zoonotic pathogen in donor blood, provides sensitive, broad coverage of HEV genotypes 1-4 to help increase the safety of the blood supply

Contact us

Do you have questions about our products or services? We’re here to help. Contact a Roche representative in your region.

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*Products of the Roche Blood Safety Solutions portfolio are not commercially available in all regions. Please contact your local Roche representative regarding availability. In the US, pre and post analytics are standalone solutions.

**cobas® DPX is an in-process test for plasma intended for further manufacture.

References:

  1. F. Hoffmann-La Roche Ltd. Data on file.