As the world’s deadliest infectious disease, tuberculosis (TB) is estimated to infect 10 million people and accounted for >1.5 million deaths in 2021.1 Caused by the bacillus Mycobacterium tuberculosis (MTB), TB co-infection with HIV and other pathogens further complicate diagnostic and treatment strategies for patients. While TB is preventable and curable, underreporting of people diagnosed and underdiagnosis remains a major challenge to the eradication of TB.