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Roche Foundation of Medicine

Comprehensive Genomic Profiling with Roche Foundation Medicine

Oncology treatment is evolving. In the current era of precision medicine, insights into a tumor's DNA can be used to personalise treatment tailored to its unique genomic profile.^1,2

Valuable Insights, Actionable Options

Roche Foundation Medicine (Foundation Medicine) is transforming cancer care by providing patients, physicians and researchers with a deep understanding of the genomic mutations that drive cancer.^3–10

What is Comprehensive Genomic Profiling (CGP)?

Comprehensive genomic profiling broadly analyses the tumour genome with a single test. Using a sample of tumour tissue or blood, Foundation Medicine tests search for alterations in over 300 cancer-related genes.^3–9

Choosing a Roche Foundation Medicine service

There are three Foundation Medicine comprehensive genomic profiles available to choose from. Physicians and researchers determine the most suitable profile for their patients' cancer type.^3–5

What is the Roche Foundation Medicine process?

Step 1.

CGP services are discussed between physicians and patients to determine suitability based on the type and stage of cancer.

Step 2.

The physician orders the chosen CGP profile online.

Step 3.

Upon completing the order, payers receive an email from Foundation Medicine to make payment for the CGP service.

Step 4.

Pathology prepares a sample of tumour tissue or blood, which is shipped to the Foundation Medicine analysis lab.

Step 5.

Upon receiving the patient specimen, genetic information (DNA or RNA) is analysed and profiled.

Step 6.

A genomic profiling report is generated and provided to the ordering physician. Healthcare professionals use the profiling report to assist in creating treatment plans for their patients.

Learn more about the Roche Foundation Medicine Profiles

Learn more

Roche Foundation Medicine facts

Delivered over 1 million test reports to patients worldwide*

Tested for >550 tumor subtypes

Still have questions?

Consult your doctor about tumor testing with a Foundation Medicine test. For additional information, feel free to contact us.

^{* Please note that the likelihood of a Foundation Medicine profile identifying a genomic alteration to assist in making treatment decisions may vary depending on factors such as tumour type and sample quality. It is recommended that you consult with your doctor to determine your suitability for a Foundation Medicine Test.}

^References

^{1 WEHI. Personalised medicine [webpage]. Available at: https://www.wehi.edu.au/research/research-fields/personalised-medicine (Accessed September 2024).}
^{2 Schwaederle M, Kurzrock R. Oncoscience 2015; 2: 779–780.}
^{3 FoundationOne®CDx Technical Information. Available at: https://www.accessdata.fda.gov/cdrh_docs/pdf17/P170019S006C.pdf (Accessed September 2024).}
^{4 FoundationOne®LiquidCDx Technical Information. Available at: https://www.accessdata.fda.gov/cdrh_docs/pdf19/P190032S001C.pdf (Accessed September 2024).}
^{5 FoundationOne®Heme Technical Specifications. Available at: https://www.foundationmedicine.com/sites/default/files/media/documents/2024-04/FoundationOne_Heme_Technical_Specifications.pdf (Accessed September 2024).}
^{6 Frampton GM et al. Nat Biotechnol 2013; 31: 1023–1031.}
^{7 Clark TA et al. J Mol Diagn 2018; 20: 686–702.}
^{8 Woodhouse R et al. PLoS One 2020; 15: e0237802.}
^{9 He J et al. Blood 2016; 127: 3004–3014.}
^{10 NCI Biomarker Testing for Cancer Treatment [webpage]. Available at: https://www.cancer.gov/about-cancer/treatment/types/biomarker-testing-cancer-treatment (Accessed September 2024).}
^{11 Schwaederle M et al. J Clin Oncol 2015; 33: 3817–3825.}
^{12 Sicklick JK et al. Nat Med 2019; 25: 744–750.}
^{13 Foundation Medicine Inc. Foundation Medicine. Available at: https://www.foundationmedicine.com/info/about-our-products-and-services (Accessed September 2024).}
^{14 Foundation Medicine Inc. The Promise and Potential of Genomic Data for the Future of Precision Medicine, February 2021. Available at: https://www.foundationmedicine.com/blog/the-promise-and-potential-of-genomic-data-for-the-future-of-precision (Accessed September 2024).}

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