Elecsys® Troponin T high sensitive

In the case of suspected AMI, prompt treatment is essential. Every 30 minutes of delay between symptoms and treatment increases the 1-year mortality rate by 7.5%¹.

Troponin is the preferred biomarker in defining AMI according to the European Society of Cardiology (ESC) guidelines² and the Roche Troponin T-high sensitive assay (cTnT-hs) is recommended by the NICE Diagnostics guidance [DG40] for the early rule out of Non-ST-Segment Elevation Myocardial Infarction (NSTEMI)³.

Roche Troponin T-high sensitive can reduce the time needed to rule-in or rule-out NSTEMI to as little as 1 hour using the 0/1 hour rule-in and rule-out algorithm recommended by the ESC².

Adopting the the ESC recommended 0/1-h cTnT-hs algorithm can

Reduce length of observation time
Triage over 75% of Emergency Department (ED) chest pain patients within 1 hour ^4,5,6

Reduce overall length of stay in the ED
Facilitate early discharge or transfer from the ED by reducing time spent in ED by 2.1 hours (33%) vs standard practice^{7, 8}

Lower overall AMI diagnostic costs
Reduce the need for additional diagnostic testing ^{7, 8}

Elecsys® Troponin T hs assay specifications

Assay specifications

Assay time

18 minutes (9 minute STAT assay)
Measuring range

3-10000 ng/L (pg/mL)
99th percentile upper reference limit

14 ng/L (pg/mL)
10th CV precision

13 ng/L (pg/mL)
Sample material

Heparin, EDTA plasma and serum
Sample volume

30 μL (e402/e801) and 50 μL (others)
Interference from Biotin

≤ 4.92 μmol/L or ≤ 1200 ng/mL

Elecsys® Troponin T hs intended use⁹

Supported by (>1300) publications and offers multiple intended uses

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Abbreviations

Non–ST-Segment Elevation Myocardial Infarction (NSTEMI), Emergency Department (ED), Acute Myocardial Infarction (AMI), Acute Coronary Syndrome (ACS), Myocardial Injury After Noncardiac Surgery (MINS) and Perioperative Myocardial Injury (PMI)

References

De Luca et al. (2004). Circulation 109, 1223-1225
Collet, JP. et al (2021). Eur Heart J 42, 1289-1367
NICE Diagnostics guidance [DG40] High-sensitivity troponin tests for the early rule out of NSTEMI (Accessed October 2022)
Twerenbold, R. et al.(2019) J Am Coll Cardiol 74(4), 483 – 94
Chew, D.P. et al. (2019) Circulation 140(19), 1543 – 56
Stoyanov, K.M. et al. (2020). EHJ ACC 9(1), 39 – 51
Giannitsis, E. et al. (2021). Clin Res Cardiol, doi: 10.1007/s00392-021-01821-2
Ambavane et al. (2017). PLoS One 12, e0187662
Elecsys Troponin T-hs and Troponin T hs STAT method sheets (V2.1). Product numbers 09315322190, 09315349190, 09315357190