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Roche Troponin T-high sensitive

Accelerated diagnosis of Acute Myocardial Infarction (AMI)

Roche Troponin T-high sensitive (cTnT-hs)

In the case of suspected AMI, prompt treatment is essential. Every 30 minutes of delay between symptoms and treatment increases the 1-year mortality rate by 7.5%1.

Troponin is the preferred biomarker in defining AMI according to the European Society of Cardiology (ESC) guidelines2 and the Roche Troponin T-high sensitive assay (cTnT-hs) is recommended by the NICE Diagnostics guidance [DG40] for the early rule out of Non-ST-Segment Elevation Myocardial Infarction (NSTEMI)3.

Roche Troponin T-high sensitive can reduce the time needed to rule-in or rule-out NSTEMI to as little as 1 hour using the 0/1 hour rule-in and rule-out algorithm recommended by the ESC2.

TnT hs accelerated algo and ESC 2020 guidelines

Adopting the the ESC recommended 0/1-h cTnT-hs algorithm can

Reduce length of observation time
Triage over 75% of Emergency Department (ED) chest pain patients within 1 hour 4,5,6

Reduce overall length of stay in the ED
Facilitate early discharge or transfer from the ED by reducing time spent in ED by 2.1 hours (33%) vs standard practice7, 8

Lower overall AMI diagnostic costs
Reduce the need for additional diagnostic testing 7, 8

Roche Troponin T-high sensitive (TnT-hs)

Elecsys® Troponin T hs assay specifications

Assay specifications

  • Assay time

    18 minutes (9 minute STAT assay)

     

     

     

  • Measuring range

    3-10000 ng/L (pg/mL)

  • 99th percentile upper reference limit

    14 ng/L (pg/mL)

  • 10th CV precision

    13 ng/L (pg/mL)

  • Sample material

    Heparin, EDTA plasma and serum

  • Sample volume

    30 μL (e402/e801) and 50 μL (others)

  • Interference from Biotin

    ≤ 4.92 μmol/L or ≤ 1200 ng/mL

Elecsys® Troponin T hs intended use9

Supported by (>1300) publications and offers multiple intended uses

TnT hs accelerated algo and ESC 2020 guidelines
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Abbreviations

Non–ST-Segment Elevation Myocardial Infarction (NSTEMI), Emergency Department (ED), Acute Myocardial Infarction (AMI), Acute Coronary Syndrome (ACS), Myocardial Injury After Noncardiac Surgery (MINS) and Perioperative Myocardial Injury (PMI)

 

References

  1. De Luca et al. (2004). Circulation 109, 1223-1225
  2. Collet, JP. et al (2021). Eur Heart J 42, 1289-1367
  3. NICE Diagnostics guidance [DG40] High-sensitivity troponin tests for the early rule out of NSTEMI (Accessed October 2022)
  4. Twerenbold, R. et al.(2019) J Am Coll Cardiol 74(4), 483 – 94
  5. Chew, D.P. et al. (2019) Circulation 140(19), 1543 – 56
  6. Stoyanov, K.M. et al. (2020). EHJ ACC 9(1), 39 – 51
  7. Giannitsis, E. et al. (2021). Clin Res Cardiol, doi: 10.1007/s00392-021-01821-2
  8. Ambavane et al. (2017). PLoS One 12, e0187662
  9. Elecsys Troponin T-hs and Troponin T hs STAT method sheets (V2.1). Product numbers 09315322190, 09315349190, 09315357190
Elecsys® NT-proBNP
Roche NT-proBNP