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Cardiovascular disease and cardiac biomarkers

Optimising cardiometabolic disease management together

Worldwide, over 30% of all deaths are attributable to cardiovascular disease Worldwide, over 30% of all deaths are attributable to cardiovascular disease (CVD).1 In the UK alone, CVD affects around seven million people and is responsible for one in four premature deaths.2 The increasing incidence and high healthcare costs associated with CVDs require a holistic approach to prevention, early detection & treatment and monitoring of disease progression. Used in conjunction with clinical information, cardiac biomarkers are crucial to support an early and accurate diagnosis.3-6

The importance of diagnostics

Diagnostic tests play a crucial part in healthcare. They account for only a fraction of the total healthcare spending (<2%), while informing ~70% of clinical decisions.7

As the global market leader in in vitro diagnostics, Roche continuously invests in evidence generation on new uses of biomarkers to improve cardiometabolic care and outcomes for patients.8‑10.  In 2023 alone, we invested CHF 13.2 million in research and development and delivered 6 new platforms, 21 diagnostic tests and 7 digital solutions,11 alongside CMD pipeline acceleration through partnerships and acquisitions.12

With biomarkers and digital solutions, Roche enables earlier diagnosis, reducing time to discharge, and providing information for personalised treatment plans.13,14

Our commitment

Roche has been the pioneer in CVD biomarkers, including high-sensitive Troponin T and NT-proBNP, With continuous investment for the past 30 years, we remain committed to optimizing cardiometabolic (CMD) care, and to continue bringing even more accurate diagnostics solutions to market. 8-10, 15-17

patient

Heart Failure

Roche NT-proBNP test:

Learn more about NT-proBNP, the gold standard heart failure biomarker8 and the importance of testing to support a timely diagnosis 

Learn more
acute-coronary-syndrome

Acute Coronary Syndrome

Roche Troponin T-high sensitive:

Triage over 75% of chest pain patients in as little as 1 hour.9-11

 

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CarDiaLogue unites the passion for cardiology and diagnostics in an engaging dialogue

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CarDiaLogue brings you the latest insights and valuable perspectives from some of the sharpest minds in cardiology to complement your specialist skills.

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Abbreviations

NT-proBNP: N-terminal prohormone of brain natriuretic peptide; POC: point of care

References

  1. Health Organization: http://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds). [Accessed October 2018, 13th] 

  2. NHS England CVD clinical policy: https://www.england.nhs.uk/ourwork/clinical-policy/cvd

  3. Roffi, M. et al. (2016). Eur Heart J 37(3), 267-315 

  4. Rutten et al. https://ipccs.org/2017/12/10/epccs-practical-guidance-on-heart-failurediagnosis-and-management-in-primary-care/[Accessed on January 2018, 23rd] 

  5.  Ponikowski et al. (2016). Eur J Heart Fail. 18:891-975 

  6. Yancy et al. (2017). Circulation. 136(6):e137-e161 

  7. Rohr, P., Binder, C., Dieterle, T., Giusti, F., Mario Messina, C. G., Toerien, E., Moch, H., & Schäfer, H. H. (2016). The Value of In Vitro Diagnostic Testing in Medical Practice: A Status Report. PLOS ONE, 11(3), e0149856.

  8. Mebazaa A, et al. Lancet. 2022;400:1938-52.

  9. Huelsmann M, et al. J Am Coll Cardiol. 2013;62:1365-72.

  10. Devereaux PJ, et al. JAMA. 2017;317:1642-51.

  11. Roche. Annual Report 2023. Available at: https://assets.roche.com/f/176343/x/98b8e2ba9d/ar23e.pdf (Accessed March 2024).

  12. Roche. 2023 results. Available at: https://assets.roche.com/f/176343/x/ac48d3ba3b/irp240201-a.pdf (Accessed March 2024).

  13. Twerenbold R, et al. Eur Heart J. 2016;37;3324-32.

  14. Pop-Busui R, et al. Diabetes Care. 2022;45:1670-90.

  15. Cobas. Elecsys ProBNP II. Available at: https://assets.roche.com/f/173850/x/70a5170dde/elecsysprobnpii-07027664190-en-can.pdf (Accessed March 2024).

  16. Cobas. Elecsys Troponin T hs. Available at: https://assets.roche.com/f/173850/x/f3fbc709bd/elecsystroponinths-09315357190-en-can.pdf (Accessed March 2024).

  17. ClinicalTrials.gov. Asian diabetes outcomes prevention trial (ADOPT) [NCT04286399]. Available at: https://clinicaltrials.gov/ct2/show/NCT04286399 (Accessed March 2024).

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