User Profile
Select your user profile
Article

Vector-borne diseases

The impact of globalization on the spread of vector-borne infections

Globalization has opened up many advancements in healthcare.

But the free flow of people has also brought about many challenges - not least the increasing ability for infectious diseases to spread1 rapidly and across borders.

Until recently, vector-borne diseases were restricted to specific geographies. But in the past few decades, rising global temperatures—a result of climate change—have allowed them to move beyond their original areas and spread quickly into other territories.2, 3

Explore the full product portfolio for vector-borne infections
View Products

Two notable examples include the expansion of West Nile virus and Chagas disease.

  • Mosquito-borne West Nile virus (WNV)4 was originally recorded primarily in the world’s Eastern Hemisphere. It was first detected in an urban area in 1996 and by 1999 it had reached New York. Then, by 2002, it had spread across the entire US.
  • Chagas disease5 - caused by a parasite which is spread in the feces of the triatomine bug - was originally confined solely to Central and South America. But the disease has now taken hold in other continents.
  • Dengue - The incidence of dengue has grown dramatically around the world in recent decades to 5.2 million in 2019. A vast majority of cases are asymptomatic or mild and self-managed, and hence the actual numbers of dengue cases are under-reported. Dengue started to spread in Europe in the recent years with a increasingly outlook.10
Mosquito
Pregnant lady

In most countries where vector-borne infections are common, prevention methods2 are well-established.

 

This is crucial since some infections of this kind, particularly with viruses, can be asymptomatic. Unexpected and undetected infections can be fatal, carry significant risk for pregnancies, and can contaminate blood6 and transplant supply, exposing the healthcare system to further complications.

Approximately 700,000 deaths annually are estimated to be due to vector-borne infections and 80% of the world's population is at risk of one or more vector-borne diseases.2 Detection and treatment are clearly vital to prevent further spread across the globe.

Roche is committed to ever improving testing and analytics, delivering state-of-the-art solutions to aid in the protection of the global blood supply from infectious diseases.

Prepared labs are essential

An intricate and evolving healthcare infrastructure underpinned by quality, safety and accuracy is the first line of defense in prevention against a vector-borne outbreak.

Emergency preparedness should be considered as part of any responsible lab’s development plan. Ensuring scalability and flexibility to respond and adapt quickly is necessary to reduce the risks from emerging vector borne diseases.

This means that the right diagnostic tools are essential for epidemic intelligence, surveillance systems, and investigative approaches, but also to safeguard our blood supply in relation to our blooddonation facilities. Reliable and accurate outcomes of consistent quality enable confidence in results and solutions.

Increased testing efficiency is one way of ensuring the quality and purity of results. Despite the high levels of safety in how blood is collected, tested, processed, and transfused, blood and plasma products do remain vulnerable to diseases.7 Labs need confidence in clinical sensitivity and experience to minimize risk.

The best diagnostic tools and platforms are ones that are scalable and fit into an existing workflow. This reduces the need to purchase new systems, and means that lab workers can utilize existing expertise, thus minimizing workload. A broad assay menu spanning across various diseases including Zika, WNV, Chagas, Dengue and Chikungunya allows for greater outbreak coverage. Advanced automation reduces the possibility of human error, meaning assay results are standardized, clinically validated, and reliable – leading to higher confidence in results.

References

  1. World Health Organization. Globalization and infectious diseases: A review of the linkages. 2004. https://apps.who.int/iris/bitstream/handle/10665/68726/TDR_STR_SEB_ST_04.2.pdf. Accessed November 28, 2022
  2. World Health Organization. Global Vector Control Response.  https://www.who.int/publications/i/item/9789241512978. Accessed November 28, 2022.
  3. Rocklöv, J., Dubrow, R. Climate change: an enduring challenge for vector-borne disease prevention and control. Nat Immunol 21, 479–483 (2020).
  4. James J. Sejvar. West Nile Virus: An Historical Overview. Ochsner J. 2003 Summer-Autumn; 5(3): 6–10.  Accessed November 28, 2022
  5. World Health Organization. Chagas disease (also known as American trypanosomiasis). https://www.who.int/news-room/fact-sheets/detail/chagas-disease-(american-trypanosomiasis) Accessed November 28, 2022.
  6. Magnus MM, Espósito DLA, Costa VAD, et al. Risk of Zika virus transmission by blood donations in Brazil. Hematol Transfus Cell Ther. 2018;40(3):250-254.
  7. Chamberland ME. Emerging infectious agents: do they pose a risk to the safety of transfused blood and blood products? Clin Infect Dis. 2002;34(6):797-805.
  8. Food and drug administration (FDA). Recommendations for Reducing the Risk of Transfusion-Transmitted Babesiosis. https://www.fda.gov/regulatory-information/search-fda-guidance-documents/recommendations-reducing-risk-transfusion-transmitted-babesiosis. Accessed November 28, 2022.
  9. Galel SA, Williamson PC, Busch MP, Stanek D, Bakkour S, Stone M, Lu K, Jones S, Rossmann SN, Pate LL; cobas Zika IND Study Group. First Zika-positive donations in the continental United States. Transfusion. 2017 Mar;57(3pt2):762-769. doi: 10.1111/trf.14029.
  10. World Health Organization. Dengue disease. https://www.who.int/news-room/fact-sheets/detail/dengue-and-severe-dengue . Accessed December 2023