Alzheimer’s disease (AD) is a public health crisis.1 The total number of people with dementia is expected to grow to 152 million in 2050 globally.1 62 % of the cases are caused by AD.2
More than 50% of patients with dementia have no formal diagnosis3-6 and, in recent surveys, half of carers have reported that an earlier diagnosis of AD would have been preferred.7
Biomarkers like amyloid and tau are recommended for the purpose of AD diagnosis and clinical trial enrolment.8,9 Several studies have reinforced that certain imaging such as amyloid positron emission tomography (PET) and cerebrospinal fluid biomarkers (CSF) are valid proxies for neuropathological changes of AD.10