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"Name": "Background Information",
"Value": "Carbonic Anhydrase IX (CA IX) is part of a family of zinc containing metalloproteins that catalyze the reversible hydration of CO2.
1 Among these, CA IX is anchored to the cell membrane and is expressed in the human gastrointestinal tract, chiefly in the stomach.
1 Data suggests consistent immunoreactivity for anti-CA IX in clear cell renal cell carcinoma (CCRCC) and clear cell papillary renal cell carcinoma (CpapRCC)
2 making it a useful marker in the differential diagnosis of the various types of renal cell carcinomas (CCRCC and CpapRCC vs other RCCs).
31. Leppilampi M, et al. Carbonic anhydrase isozymes IX and XII in gastric tumors. World J Gastroenterol. 2003; 9:1398-1403.
2. Williamson SR, et al. Clear cell papillary renal cell carcinoma: differential diagnosis and extended immunohistochemical profile. Mod Pathol. 2013; 26:697-708.
3. Gupta, R et al. Diagnostic implications of transcription factor Pax 2 protein and transmembrane enzyme complex carbonic anhydrase IX immunoreactivity in adult renal epithelial neoplasms. Am J Surg Pathol. 2009; 33:241-7.",
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This antibody is optimally diluted to be compatible with VENTANA detection kits and BenchMark IHC/ISH instruments. Refer to the Tables in the Instructions for Use section for recommended staining protocols. Each step in the staining protocol includes incubation for a precise time at a specifi c temperature. At the end of each incubation step, the sections are rinsed by the BenchMark IHC/ISH instruments to stop the reaction and remove unbound material that would hinder the desired reaction in subsequent steps. To minimize evaporation of the aqueous reagents from the specimen-containing slide, a coverslip solution is applied in the slide stainer. For more detailed information on instrument operation, refer to the appropriate BenchMark IHC/ISH instruments Operator’s Manual.",
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