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"Value": "CD21, also known as complement receptor 2, C3d receptor or Epstein-Barr virus (EBV) receptor, is a 140-kD membrane protein on B-lymphocytes to which the EBV binds during infection of these cells.
1 CD21 is expressed primarily on follicular dendritic cells and mature B-lymphocytes found in normal lymph node and tonsillar tissue and is absent on T-lymphocytes, monocytes, and granulocytes.
2,3 Anti-CD21 is useful in the identification of follicular dendritic cell framework in various lymphomas, particularly follicular lymphomas, and is also expressed in tumors of dendritic cell origin such as follicular dendritic cell sarcoma.
2,4-71. Cheuk, W et al. “Inflammatory pseudotumor-like follicular dendritic cell tumor: a distinctive low-grade malignant intra-abdominal neoplasm with consistent Epstein-Barr virus association.” The American journal of surgical pathology vol. 25,6 (2001): 721-31.
2. Pileri, S A et al. “Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases.” Histopathology vol. 41,1 (2002): 1-29.
3. Maeda, Kunihiko et al. “Immunohistochemical recognition of human follicular dendritic cells (FDCs) in routinely processed paraffin sections.” The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society vol. 50,11 (2002): 1475-86.
4. Biddle, David A et al. “Extranodal follicular dendritic cell sarcoma of the head and neck region: three new cases, with a review of the literature.” Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc vol. 15,1 (2002): 50-8.
5. Chan, A C et al. “Development of follicular dendritic cell sarcoma in hyalinevascular Castleman’s disease of the nasopharynx: tracing its evolution by sequential biopsies.” Histopathology vol. 38,6 (2001): 510-8.
6. Chang, Kong-Chao et al. “Germinal centre-like versus undifferentiated stromal immunophenotypes in follicular lymphoma.” The Journal of pathology vol. 201,3 (2003): 404-12.
7. Chuang, Shih-Sung et al. “Differential diagnosis of angioimmunoblastic T-cell lymphoma with seropositivity for anti-HTLV antibody from adult T-cell leukemia/ lymphoma.” International journal of hematology vol. 91,4 (2010): 687-91.",
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