{
"ProductData": {
"ID": "RTD000723",
"ProductType": "Others",
"BrandName": "CD21 (2G9) Mouse Monoclonal Antibody",
"ProductNameAddition": "",
"RegulatoryDisclaimer1": "For in vitro diagnostic use.",
"DisclaimerGroup1": "IVD",
"RegulatoryDisclaimer2": null,
"DisclaimerGroup2": null,
"RegulatoryDisclaimer3": null,
"SampleType": [
"Formalin-Fixed Paraffin-Embedded Tissue (FFPET)"
],
"LicenseDisclaimers": [
],
"RelatedLinks": "
Cell Marque - Instructions for UseCell Marque - Safety Data Sheet",
"Clone": "2G9",
"ControlTissue": [
"Lymph Node",
"Tonsil"
],
"ISOtypes": "IgG
2a",
"Species": [
"Mouse"
],
"StainLocalization": [
"Membrane"
],
"ProductNameGlobal": "CD21 2G9"
},
"ProductImageDetails": {
"ImagePath": "https://pim-media.roche.com/Images/Product_RTD000723_im_en.jpg",
"ImageType": "Image main"
},
"Product2Taxonomy": {
"Product2TaxonomyReferences": [
{
"StructureSystemIdentifier": "Product_Grouping",
"StructureSystemName": "Product Grouping",
"NodeID": "05-0002",
"StructureNodeStatus": "Active",
"NodeName": "IHC Primary Antibodies"
},
{
"StructureSystemIdentifier": "OWP_Techniques",
"StructureSystemName": "Techniques",
"NodeID": "073-00",
"StructureNodeStatus": "Active",
"NodeName": "Immunohistochemistry (IHC)"
},
{
"StructureSystemIdentifier": "Lab_Type",
"StructureSystemName": "Lab Types",
"NodeID": "080-00",
"StructureNodeStatus": "Active",
"NodeName": "Pathology Lab"
},
{
"StructureSystemIdentifier": "Health_Topics",
"StructureSystemName": "Health Topics",
"NodeID": "19-00-00",
"StructureNodeStatus": "Active",
"NodeName": "Oncology"
},
{
"StructureSystemIdentifier": "Product_Solutions",
"StructureSystemName": "Product Solutions",
"NodeID": "010",
"StructureNodeStatus": "Active",
"NodeName": "Histopathology"
},
{
"StructureSystemIdentifier": "Applications",
"StructureSystemName": "Applications",
"NodeID": "99-00-00",
"StructureNodeStatus": "Inactive",
"NodeName": ""
},
{
"StructureSystemIdentifier": "Pathogens",
"StructureSystemName": "Pathogens",
"NodeID": "99-00-00",
"StructureNodeStatus": "Inactive",
"NodeName": ""
},
{
"StructureSystemIdentifier": "Disease_Areas",
"StructureSystemName": "Disease Areas",
"NodeID": "99-00-00",
"StructureNodeStatus": "Inactive",
"NodeName": ""
},
{
"StructureSystemIdentifier": "OWP_Product_Types",
"StructureSystemName": "Product Types",
"NodeID": "15-000-00",
"StructureNodeStatus": "Active",
"NodeName": "Primary Antibody"
},
{
"StructureSystemIdentifier": "OWP_Family",
"StructureSystemName": "Product Families",
"NodeID": "080",
"StructureNodeStatus": "Active",
"NodeName": "BenchMark"
}
]
},
"Product2Materials": {
"P2MaterialReferences": [
{
"MaterialNum": "05269059001",
"MaterialDescription": "Cell Marque, CD21 (2G9)",
"RegisteredProductName": "CD21 (2G9)",
"GTIN": "00841683100461",
"ProductCategoryText": "Reagents, kits",
"OldMaterialNumber": "760-4245",
"PackSizePIM360": "50 tests",
"PackSizeDescPIM360": "Not Available",
"MaterialAnnotation": "",
"ReadyForUse": "true",
"OrderInformation": ""
}
]
},
"Product2Products": {
"Product2ProductReference": [
{
"ProductID": "INS_2099",
"BrandName": "BenchMark ULTRA",
"ProductNameAddition": "",
"ReferenceType": "Instrument",
"Classification": [
{
"IdentifierofStructureSystem": "1",
"NameofStructureSystem": "GPCH",
"StructureNodeID": "2300",
"StructureGroupPath": "Histology->Systems / Digital Products->Advanced Staining->BenchMark ULTRA",
"StructureGroupName": "BenchMark ULTRA",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Product_Types",
"NameofStructureSystem": "Product Types",
"StructureNodeID": "10-000-00",
"StructureGroupPath": "Analyzer Instruments and Systems",
"StructureGroupName": "Analyzer Instruments and Systems",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Family",
"NameofStructureSystem": "Product Families",
"StructureNodeID": "080",
"StructureGroupPath": "BenchMark",
"StructureGroupName": "BenchMark",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Lab_Type",
"NameofStructureSystem": "Lab Types",
"StructureNodeID": "080-00",
"StructureGroupPath": "Pathology Lab",
"StructureGroupName": "Pathology Lab",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Product_Solutions",
"NameofStructureSystem": "Product Solutions",
"StructureNodeID": "010",
"StructureGroupPath": "Histopathology",
"StructureGroupName": "Histopathology",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Techniques",
"NameofStructureSystem": "Techniques",
"StructureNodeID": "073-00",
"StructureGroupPath": "Immunohistochemistry (IHC)",
"StructureGroupName": "Immunohistochemistry (IHC)",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Techniques",
"NameofStructureSystem": "Techniques",
"StructureNodeID": "075-00",
"StructureGroupPath": "In situ Hybridization (ISH)",
"StructureGroupName": "In situ Hybridization (ISH)",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Applications",
"NameofStructureSystem": "Applications",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Disease_Areas",
"NameofStructureSystem": "Disease Areas",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Pathogens",
"NameofStructureSystem": "Pathogens",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Health_Topics",
"NameofStructureSystem": "Health Topics",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
}
]
},
{
"ProductID": "INS_2580",
"BrandName": "BenchMark GX",
"ProductNameAddition": "",
"ReferenceType": "Instrument",
"Classification": [
{
"IdentifierofStructureSystem": "1",
"NameofStructureSystem": "GPCH",
"StructureNodeID": "6151",
"StructureGroupPath": "Histology->Systems / Digital Products->Advanced Staining->BenchMark GX",
"StructureGroupName": "BenchMark GX",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Product_Types",
"NameofStructureSystem": "Product Types",
"StructureNodeID": "10-000-00",
"StructureGroupPath": "Analyzer Instruments and Systems",
"StructureGroupName": "Analyzer Instruments and Systems",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Family",
"NameofStructureSystem": "Product Families",
"StructureNodeID": "080",
"StructureGroupPath": "BenchMark",
"StructureGroupName": "BenchMark",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Lab_Type",
"NameofStructureSystem": "Lab Types",
"StructureNodeID": "080-00",
"StructureGroupPath": "Pathology Lab",
"StructureGroupName": "Pathology Lab",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Product_Solutions",
"NameofStructureSystem": "Product Solutions",
"StructureNodeID": "010",
"StructureGroupPath": "Histopathology",
"StructureGroupName": "Histopathology",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Techniques",
"NameofStructureSystem": "Techniques",
"StructureNodeID": "999-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Applications",
"NameofStructureSystem": "Applications",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Disease_Areas",
"NameofStructureSystem": "Disease Areas",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Pathogens",
"NameofStructureSystem": "Pathogens",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Health_Topics",
"NameofStructureSystem": "Health Topics",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
}
]
},
{
"ProductID": "INS_6476",
"BrandName": "BenchMark ULTRA PLUS",
"ProductNameAddition": "",
"ReferenceType": "Instrument",
"Classification": [
{
"IdentifierofStructureSystem": "1",
"NameofStructureSystem": "GPCH",
"StructureNodeID": "9570",
"StructureGroupPath": "Histology->Systems / Digital Products->Advanced Staining->BenchMark ULTRA PLUS",
"StructureGroupName": "BenchMark ULTRA PLUS",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Product_Types",
"NameofStructureSystem": "Product Types",
"StructureNodeID": "10-000-00",
"StructureGroupPath": "Analyzer Instruments and Systems",
"StructureGroupName": "Analyzer Instruments and Systems",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Family",
"NameofStructureSystem": "Product Families",
"StructureNodeID": "080",
"StructureGroupPath": "BenchMark",
"StructureGroupName": "BenchMark",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Lab_Type",
"NameofStructureSystem": "Lab Types",
"StructureNodeID": "080-00",
"StructureGroupPath": "Pathology Lab",
"StructureGroupName": "Pathology Lab",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Product_Solutions",
"NameofStructureSystem": "Product Solutions",
"StructureNodeID": "010",
"StructureGroupPath": "Histopathology",
"StructureGroupName": "Histopathology",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Techniques",
"NameofStructureSystem": "Techniques",
"StructureNodeID": "075-00",
"StructureGroupPath": "In situ Hybridization (ISH)",
"StructureGroupName": "In situ Hybridization (ISH)",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Techniques",
"NameofStructureSystem": "Techniques",
"StructureNodeID": "073-00",
"StructureGroupPath": "Immunohistochemistry (IHC)",
"StructureGroupName": "Immunohistochemistry (IHC)",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Applications",
"NameofStructureSystem": "Applications",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Pathogens",
"NameofStructureSystem": "Pathogens",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Disease_Areas",
"NameofStructureSystem": "Disease Areas",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Health_Topics",
"NameofStructureSystem": "Health Topics",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
}
]
}
]
},
"ProductSpec": [
{
"ProductSpecVariant": {
"Chapters": [
{
"Name": "Storage Conditions (Product)",
"Value": "Upon receipt and when not in use, store at 2-8°C. Do not freeze.",
"Language": "en",
"Country": "XG",
"Code": "Storage Conditions (Product)"
},
{
"Name": "Content",
"Value": "One dispenser of this antibody contains sufficient prediluted reagent for 50 tests.",
"Language": "en",
"Country": "XG",
"Code": "Content"
},
{
"Name": "Intended Use",
"Value": "CD21 (2G9) Mouse Monoclonal Primary Antibody is intended for laboratory use in the detection of the CD21 protein in formalin-fixed, paraffin-embedded human tissue stained in qualitative immunohistochemistry (IHC) on BenchMark IHC/ISH instruments. This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls. This antibody is intended for
in vitro diagnostic (IVD) use.",
"Language": "en",
"Country": "XG",
"Code": "Intended Use"
},
{
"Name": "Background Information",
"Value": "CD21, also known as complement receptor 2, C3d receptor or Epstein-Barr virus (EBV) receptor, is a 140-kD membrane protein on B-lymphocytes to which the EBV binds during infection of these cells.
1 CD21 is expressed primarily on follicular dendritic cells and mature B-lymphocytes found in normal lymph node and tonsillar tissue and is absent on T-lymphocytes, monocytes, and granulocytes.
2,3 Anti-CD21 is useful in the identification of follicular dendritic cell framework in various lymphomas, particularly follicular lymphomas, and is also expressed in tumors of dendritic cell origin such as follicular dendritic cell sarcoma.
2,4-71. Cheuk, W et al. “Inflammatory pseudotumor-like follicular dendritic cell tumor: a distinctive low-grade malignant intra-abdominal neoplasm with consistent Epstein-Barr virus association.” The American journal of surgical pathology vol. 25,6 (2001): 721-31.
2. Pileri, S A et al. “Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases.” Histopathology vol. 41,1 (2002): 1-29.
3. Maeda, Kunihiko et al. “Immunohistochemical recognition of human follicular dendritic cells (FDCs) in routinely processed paraffin sections.” The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society vol. 50,11 (2002): 1475-86.
4. Biddle, David A et al. “Extranodal follicular dendritic cell sarcoma of the head and neck region: three new cases, with a review of the literature.” Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc vol. 15,1 (2002): 50-8.
5. Chan, A C et al. “Development of follicular dendritic cell sarcoma in hyalinevascular Castleman’s disease of the nasopharynx: tracing its evolution by sequential biopsies.” Histopathology vol. 38,6 (2001): 510-8.
6. Chang, Kong-Chao et al. “Germinal centre-like versus undifferentiated stromal immunophenotypes in follicular lymphoma.” The Journal of pathology vol. 201,3 (2003): 404-12.
7. Chuang, Shih-Sung et al. “Differential diagnosis of angioimmunoblastic T-cell lymphoma with seropositivity for anti-HTLV antibody from adult T-cell leukemia/ lymphoma.” International journal of hematology vol. 91,4 (2010): 687-91.",
"Language": "en",
"Country": "XG",
"Code": "Background Information"
},
{
"Name": "Principle",
"Value": "CD21 (2G9) Mouse Monoclonal Antibody (this antibody) may be used as the primary\nantibody for immunohistochemical staining of formalin-fixed, paraffin-embedded tissue\nsections. In general, immunohistochemical staining allows the visualization of antigens\nvia the sequential application of a specific antibody (primary antibody) to the antigen, a secondary antibody (link antibody) to the primary antibody, an enzyme complex and a\nchromogenic substrate with interposed washing steps. The enzymatic activation of the\nchromogen results in a visible reaction product at the antigen site. The specimen may then be\ncounterstained and a coverslip applied. Results are interpreted using a light microscope and\naid in the differential diagnosis of pathophysiological processes, which may or may not be\nassociated with a particular antigen.\n
\n
\nThis antibody is optimally diluted to be compatible with VENTANA detection kits and\nBenchMark IHC/ISH instruments. Refer to the Tables in the Instructions for Use section for\nrecommended staining protocols. Each step in the staining protocol includes incubation for\na precise time at a specific temperature. At the end of each incubation step, the sections are\nrinsed by the BenchMark IHC/ISH instruments to stop the reaction and remove unbound\nmaterial that would hinder the desired reaction in subsequent steps. To minimize evaporation\nof the aqueous reagents from the specimen-containing slide, a coverslip solution is applied\nin the slide stainer. For more detailed information on instrument operation, refer to the\nappropriate BenchMark IHC/ISH instruments Operator’s Manual.",
"Language": "en",
"Country": "XG",
"Code": "Principle"
},
{
"Name": "Product Purpose",
"Value": "CD21 (2G9) Mouse Monoclonal Primary Antibody is intended for laboratory use in the detection of the CD21 protein in formalin-fixed, paraffin-embedded human tissue stained in qualitative immunohistochemistry (IHC) on BenchMark IHC/ISH instruments. This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls. This antibody is intended for
in vitro diagnostic (IVD) use.",
"Language": "en",
"Country": "XG",
"Code": "Product Purpose"
}
]
}
}
]
}