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"StructureGroupName": "", "StructureNodeStatus": "Inactive" }, { "IdentifierofStructureSystem": "Pathogens", "NameofStructureSystem": "Pathogens", "StructureNodeID": "99-00-00", "StructureGroupPath": "", "StructureGroupName": "", "StructureNodeStatus": "Inactive" }, { "IdentifierofStructureSystem": "Disease_Areas", "NameofStructureSystem": "Disease Areas", "StructureNodeID": "99-00-00", "StructureGroupPath": "", "StructureGroupName": "", "StructureNodeStatus": "Inactive" }, { "IdentifierofStructureSystem": "Health_Topics", "NameofStructureSystem": "Health Topics", "StructureNodeID": "99-00-00", "StructureGroupPath": "", "StructureGroupName": "", "StructureNodeStatus": "Inactive" } ] } ] }, "ProductSpec": [ { "ProductSpecVariant": { "Chapters": [ { "Name": "Storage Conditions (Product)", "Value": "Upon receipt and when not in use, store at 2-8°C. Do not freeze.", "Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Intended Use", "Value": "CONFIRM anti-CD8 (SP57) Rabbit Monoclonal Primary Antibody is intended for laboratory use in the qualitative immunohistochemical detection of CD8 by light microscopy in sections of formalin-fixed, paraffin- embedded tissue stained on a BenchMark IHC/ISH instrument.

This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information and proper controls.

This antibody is intended for in vitro diagnostic (IVD) use.", "Language": "en", "Country": "XG", "Code": "Intended Use" }, { "Name": "Content", "Value": "CONFIRM anti-CD8 (SP57) antibody contains sufficient reagent for 50 tests.

One 5 mL dispenser of CONFIRM anti-CD8 (SP57) antibody contains approximately 2 μg of a rabbit monoclonal SP57 antibody.
The antibody is diluted in Tris-HCl with carrier protein and 0.10% ProClin 300, a preservative.
Specific antibody concentration is approximately 0.4 μg/mL.
CONFIRM anti-CD8 (SP57) antibody is a recombinant rabbit monoclonal antibody produced as Protein A-purified cell culture supernatant.

Refer to the appropriate VENTANA detection kit method sheet for detailed descriptions of: Principle of the Procedure, Material and Methods, Specimen Collection and Preparation for Analysis, Quality Control Procedures, Troubleshooting, Interpretation of Results, and Limitations.", "Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Background Information", "Value": "CD8 is a 68 kDa heterodimeric, transmembrane glycoprotein expressed by cytotoxic T- cells and at low levels in NK-cells and a subpopulation of bone marrow cells.1,2,3 CD8 acts as a co-receptor for the T-cell receptor and interacts directly with major histo- compatibility complex class I molecules on antigen-presenting cells, which stimulate T-cell activation.1,3

CD8 is absent on immature T-cells and expressed in later stages of T-cell development as the cell matures into a cytotoxic T-cell.4,5 CD8 is generally expressed in neoplasms derived from cytotoxic T-cells, including T-lymphoblastic lymphoma, panniculitis-like T-cell lymphoma, extranodal T-cell lymphoma, and NK/T-cell lymphoma, but is generally absent in lymphomas derived from helper T-cells.1,2,3,5 Some T-cell lymphomas, such as anaplastic large cell lymphoma, mycosis fungoides, and peripheral T-cell lymphoma (NOS) may aberrantly express CD8.1,2,5

The detection of CD8 by immunohistochemistry (IHC) with the CONFIRM anti-CD8 (SP57) antibody, when evaluated with other markers, may be used to aid in the identification of normal cytotoxic T-cells and sub-classification of T-cell lymphoma. The cellular staining pattern for CONFIRM anti-CD8 (SP57) antibody is membranous.

1. Dabbs DJ. Diagnostic Immunohistochemistry Theranostic and Genomic Applications, 5th edition. Vol 5. Amsterdam, Netherlands: Elsevier; 2019.
2. Higgins RA, Blankenship JE, Kinney MC. Application of immunohistochemistry in the diagnosis of non-Hodgkin and Hodgkin lymphoma. Arch Pathol Lab Med. 2008;132(3):441-461.
3. Naeim F. Principles of Immunophenotyping. In: Naeim F, Rao PN, Grody WW, eds. Hematopathology: Morphology, Immunophenotype, Cytogenetics, and Molecular Approaches. Cambridge, MA: Academic Press; 2009.
4. Rich R, Fleisher T, Shearer W, Frew A, Weyand C. Clinical Immunology Principles and Practice, 5th edition. Vol 5. Amsterdam, Netherlands: Elsevier; 2018.
5. Swerdlow SH, Campo E, Harris NL, et al. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th edition. Vol 4. Lyon, France: International Agency for Research on Cancer; 2008.", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Principle", "Value": "CONFIRM anti-CD8 (SP57) antibody binds to the CD8 glycoprotein in formalin-fixed, paraffin-embedded (FFPE) tissue sections. This antibody can be visualized using ultraView Universal DAB Detection Kit (Cat. No. 760-500 / 05269806001). Refer to the respective method sheet for further information.", "Language": "en", "Country": "XG", "Code": "Principle" }, { "Name": "Product Purpose", "Value": "CONFIRM anti-CD8 (SP57) Rabbit Monoclonal Primary Antibody is intended for laboratory use in the qualitative immunohistochemical detection of CD8 by light microscopy in sections of formalin-fixed, paraffin- embedded tissue stained on a BenchMark IHC/ISH instrument.

This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information and proper controls.

This antibody is intended for in vitro diagnostic (IVD) use.", "Language": "en", "Country": "XG", "Code": "Product Purpose" } ] } } ] }

CONFIRM anti-CD8 (SP57) Rabbit Monoclonal Primary Antibody

IVD For in vitro diagnostic use.
CONFIRM anti-CD8 (SP57) Rabbit Monoclonal Primary Antibody

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