{
"ProductData": {
"ID": "RTD000902",
"ProductType": "Others",
"BrandName": "Factor VIII-R Ag. Rabbit Polyclonal Antibody",
"ProductNameAddition": "",
"RegulatoryDisclaimer1": "For in vitro diagnostic use.",
"DisclaimerGroup1": "IVD",
"RegulatoryDisclaimer2": null,
"DisclaimerGroup2": null,
"RegulatoryDisclaimer3": null,
"SampleType": [
"Formalin-Fixed Paraffin-Embedded Tissue (FFPET)"
],
"LicenseDisclaimers": [
],
"RelatedLinks": "
Cell Marque - Instructions for UseCell Marque - Safety Data Sheet",
"Clone": "",
"ControlTissue": [
"Placenta",
"Skin"
],
"ISOtypes": "",
"Species": [
"Rabbit"
],
"StainLocalization": [
"Cytoplasm"
],
"ProductNameGlobal": "Factor VIII-R Ag. polyclonal"
},
"ProductImageDetails": {
"ImagePath": "https://pim-media.roche.com/Images/Product_RTD000902_im_en.jpg",
"ImageType": "Image main"
},
"Product2Taxonomy": {
"Product2TaxonomyReferences": [
{
"StructureSystemIdentifier": "Product_Grouping",
"StructureSystemName": "Product Grouping",
"NodeID": "05-0002",
"StructureNodeStatus": "Active",
"NodeName": "IHC Primary Antibodies"
},
{
"StructureSystemIdentifier": "OWP_Techniques",
"StructureSystemName": "Techniques",
"NodeID": "073-00",
"StructureNodeStatus": "Active",
"NodeName": "Immunohistochemistry (IHC)"
},
{
"StructureSystemIdentifier": "Lab_Type",
"StructureSystemName": "Lab Types",
"NodeID": "080-00",
"StructureNodeStatus": "Active",
"NodeName": "Pathology Lab"
},
{
"StructureSystemIdentifier": "Disease_Areas",
"StructureSystemName": "Disease Areas",
"NodeID": "38-00-00",
"StructureNodeStatus": "Active",
"NodeName": "Skin cancer"
},
{
"StructureSystemIdentifier": "Product_Solutions",
"StructureSystemName": "Product Solutions",
"NodeID": "010",
"StructureNodeStatus": "Active",
"NodeName": "Histopathology"
},
{
"StructureSystemIdentifier": "Applications",
"StructureSystemName": "Applications",
"NodeID": "99-00-00",
"StructureNodeStatus": "Inactive",
"NodeName": ""
},
{
"StructureSystemIdentifier": "Pathogens",
"StructureSystemName": "Pathogens",
"NodeID": "99-00-00",
"StructureNodeStatus": "Inactive",
"NodeName": ""
},
{
"StructureSystemIdentifier": "Health_Topics",
"StructureSystemName": "Health Topics",
"NodeID": "22-00-00",
"StructureNodeStatus": "Active",
"NodeName": "Dermatology"
},
{
"StructureSystemIdentifier": "OWP_Product_Types",
"StructureSystemName": "Product Types",
"NodeID": "15-000-00",
"StructureNodeStatus": "Active",
"NodeName": "Primary Antibody"
},
{
"StructureSystemIdentifier": "OWP_Family",
"StructureSystemName": "Product Families",
"NodeID": "080",
"StructureNodeStatus": "Active",
"NodeName": "BenchMark"
}
]
},
"Product2Materials": {
"P2MaterialReferences": [
{
"MaterialNum": "05267528001",
"MaterialDescription": "CELL MARQUE, FACTOR 8-R AG.",
"RegisteredProductName": "Factor VIII-R Ag. (polyclonal)",
"GTIN": "00841683100140",
"ProductCategoryText": "Reagents, kits",
"OldMaterialNumber": "760-2642",
"PackSizePIM360": "50 tests",
"PackSizeDescPIM360": "Not Available",
"MaterialAnnotation": "",
"ReadyForUse": "true",
"OrderInformation": ""
}
]
},
"Product2Products": {
"Product2ProductReference": [
{
"ProductID": "INS_2099",
"BrandName": "BenchMark ULTRA",
"ProductNameAddition": "",
"ReferenceType": "Instrument",
"Classification": [
{
"IdentifierofStructureSystem": "1",
"NameofStructureSystem": "GPCH",
"StructureNodeID": "2300",
"StructureGroupPath": "Histology->Systems / Digital Products->Advanced Staining->BenchMark ULTRA",
"StructureGroupName": "BenchMark ULTRA",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Product_Types",
"NameofStructureSystem": "Product Types",
"StructureNodeID": "10-000-00",
"StructureGroupPath": "Analyzer Instruments and Systems",
"StructureGroupName": "Analyzer Instruments and Systems",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Family",
"NameofStructureSystem": "Product Families",
"StructureNodeID": "080",
"StructureGroupPath": "BenchMark",
"StructureGroupName": "BenchMark",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Lab_Type",
"NameofStructureSystem": "Lab Types",
"StructureNodeID": "080-00",
"StructureGroupPath": "Pathology Lab",
"StructureGroupName": "Pathology Lab",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Product_Solutions",
"NameofStructureSystem": "Product Solutions",
"StructureNodeID": "010",
"StructureGroupPath": "Histopathology",
"StructureGroupName": "Histopathology",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Techniques",
"NameofStructureSystem": "Techniques",
"StructureNodeID": "073-00",
"StructureGroupPath": "Immunohistochemistry (IHC)",
"StructureGroupName": "Immunohistochemistry (IHC)",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Techniques",
"NameofStructureSystem": "Techniques",
"StructureNodeID": "075-00",
"StructureGroupPath": "In situ Hybridization (ISH)",
"StructureGroupName": "In situ Hybridization (ISH)",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Applications",
"NameofStructureSystem": "Applications",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Disease_Areas",
"NameofStructureSystem": "Disease Areas",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Pathogens",
"NameofStructureSystem": "Pathogens",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Health_Topics",
"NameofStructureSystem": "Health Topics",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
}
]
},
{
"ProductID": "INS_2580",
"BrandName": "BenchMark GX",
"ProductNameAddition": "",
"ReferenceType": "Instrument",
"Classification": [
{
"IdentifierofStructureSystem": "1",
"NameofStructureSystem": "GPCH",
"StructureNodeID": "6151",
"StructureGroupPath": "Histology->Systems / Digital Products->Advanced Staining->BenchMark GX",
"StructureGroupName": "BenchMark GX",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Product_Types",
"NameofStructureSystem": "Product Types",
"StructureNodeID": "10-000-00",
"StructureGroupPath": "Analyzer Instruments and Systems",
"StructureGroupName": "Analyzer Instruments and Systems",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Family",
"NameofStructureSystem": "Product Families",
"StructureNodeID": "080",
"StructureGroupPath": "BenchMark",
"StructureGroupName": "BenchMark",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Lab_Type",
"NameofStructureSystem": "Lab Types",
"StructureNodeID": "080-00",
"StructureGroupPath": "Pathology Lab",
"StructureGroupName": "Pathology Lab",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Product_Solutions",
"NameofStructureSystem": "Product Solutions",
"StructureNodeID": "010",
"StructureGroupPath": "Histopathology",
"StructureGroupName": "Histopathology",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Techniques",
"NameofStructureSystem": "Techniques",
"StructureNodeID": "999-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Applications",
"NameofStructureSystem": "Applications",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Disease_Areas",
"NameofStructureSystem": "Disease Areas",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Pathogens",
"NameofStructureSystem": "Pathogens",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Health_Topics",
"NameofStructureSystem": "Health Topics",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
}
]
},
{
"ProductID": "INS_6476",
"BrandName": "BenchMark ULTRA PLUS",
"ProductNameAddition": "",
"ReferenceType": "Instrument",
"Classification": [
{
"IdentifierofStructureSystem": "1",
"NameofStructureSystem": "GPCH",
"StructureNodeID": "9570",
"StructureGroupPath": "Histology->Systems / Digital Products->Advanced Staining->BenchMark ULTRA PLUS",
"StructureGroupName": "BenchMark ULTRA PLUS",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Product_Types",
"NameofStructureSystem": "Product Types",
"StructureNodeID": "10-000-00",
"StructureGroupPath": "Analyzer Instruments and Systems",
"StructureGroupName": "Analyzer Instruments and Systems",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Family",
"NameofStructureSystem": "Product Families",
"StructureNodeID": "080",
"StructureGroupPath": "BenchMark",
"StructureGroupName": "BenchMark",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Lab_Type",
"NameofStructureSystem": "Lab Types",
"StructureNodeID": "080-00",
"StructureGroupPath": "Pathology Lab",
"StructureGroupName": "Pathology Lab",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Product_Solutions",
"NameofStructureSystem": "Product Solutions",
"StructureNodeID": "010",
"StructureGroupPath": "Histopathology",
"StructureGroupName": "Histopathology",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Techniques",
"NameofStructureSystem": "Techniques",
"StructureNodeID": "075-00",
"StructureGroupPath": "In situ Hybridization (ISH)",
"StructureGroupName": "In situ Hybridization (ISH)",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Techniques",
"NameofStructureSystem": "Techniques",
"StructureNodeID": "073-00",
"StructureGroupPath": "Immunohistochemistry (IHC)",
"StructureGroupName": "Immunohistochemistry (IHC)",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Applications",
"NameofStructureSystem": "Applications",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Pathogens",
"NameofStructureSystem": "Pathogens",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Disease_Areas",
"NameofStructureSystem": "Disease Areas",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Health_Topics",
"NameofStructureSystem": "Health Topics",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
}
]
}
]
},
"ProductSpec": [
{
"ProductSpecVariant": {
"Chapters": [
{
"Name": "Storage Conditions (Product)",
"Value": "Upon receipt and when not in use, store at 2-8°C. Do not freeze.",
"Language": "en",
"Country": "XG",
"Code": "Storage Conditions (Product)"
},
{
"Name": "Content",
"Value": "One dispenser of this antibody contains sufficient prediluted reagent for 50 tests.",
"Language": "en",
"Country": "XG",
"Code": "Content"
},
{
"Name": "Intended Use",
"Value": "Factor VIII-R Ag. Rabbit Polyclonal Primary Antibody is intended for laboratory use in the detection of the Factor VIII-R Ag. protein in formalin-fixed, paraffin-embedded human tissue stained in qualitative immunohistochemistry (IHC) on BenchMark IHC/ISH instruments. This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls. This antibody is intended for
in vitro diagnostic (IVD) use.",
"Language": "en",
"Country": "XG",
"Code": "Intended Use"
},
{
"Name": "Background Information",
"Value": "Factor VIII-Related Antigen or von Willebrand factor is a glycoprotein associated with hemostasis in promoting adhesion of platelets. Anti-Factor VIII Related Antigen reactivity is seen in endothelial cells, hemangioma, and the majority of tumors of endothelial origin such as Kaposi’s sarcoma and angiosarcoma.
1-51. Nichols GE, et al. Lobular capillary hemangioma. An immunohistochemical study including steroid hormone receptor status. Am J Clin Pathol. 1992; 97:770-5.
2. Falk S, et al. Primary angiosarcoma of the spleen. A clinicopathologic study of 40 cases. Am J Surg Pathol. 1993; 17:959-70.
3. Meis-Kindblom JM, et al. Angiosarcoma of soft tissue: a study of 80 cases. Am J Surg Pathol. 1998; 22:683-97.
4. Allison KH, et al. Angiosarcoma involving the gastrointestinal tract: a series of primary and metastatic cases. Am J Surg Pathol. 2004; 28:298-307.
5. Peyvandi F, et al. Role of von Willebrand factor in the haemostasis. Blood Transfus. 2011; 9 Suppl 2:s3-8.",
"Language": "en",
"Country": "XG",
"Code": "Background Information"
},
{
"Name": "Principle",
"Value": "Factor VIII-R Ag. Rabbit Polyclonal Antibody (this antibody) may be used as the primary\nantibody for immunohistochemical staining of formalin-fixed, paraffin-embedded tissue\nsections. In general, immunohistochemical staining allows the visualization of antigens\nvia the sequential application of a specific antibody (primary antibody) to the antigen, a\nsecondary antibody (link antibody) to the primary antibody, an enzyme complex and a\nchromogenic substrate with interposed washing steps. The enzymatic activation of the\nchromogen results in a visible reaction product at the antigen site. The specimen may then be\ncounterstained and a coverslip applied. Results are interpreted using a light microscope and\naid in the differential diagnosis of pathophysiological processes, which may or may not be\nassociated with a particular antigen.\n
\n
\nThis antibody is optimally diluted to be compatible with VENTANA detection kits and\nBenchMark IHC/ISH instruments. Refer to the Tables in the Instructions for Use section for\nrecommended staining protocols. Each step in the staining protocol includes incubation for\na precise time at a specific temperature. At the end of each incubation step, the sections are\nrinsed by the BenchMark IHC/ISH instruments to stop the reaction and remove unbound\nmaterial that would hinder the desired reaction in subsequent steps. To minimize evaporation\nof the aqueous reagents from the specimen-containing slide, a coverslip solution is applied\nin the slide stainer. For more detailed information on instrument operation, refer to the\nappropriate BenchMark IHC/ISH instruments Operator’s Manual.",
"Language": "en",
"Country": "XG",
"Code": "Principle"
},
{
"Name": "Product Purpose",
"Value": "Factor VIII-R Ag. Rabbit Polyclonal Primary Antibody is intended for laboratory use in the detection of the Factor VIII-R Ag. protein in formalin-fixed, paraffin-embedded human tissue stained in qualitative immunohistochemistry (IHC) on BenchMark IHC/ISH instruments. This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls. This antibody is intended for
in vitro diagnostic (IVD) use.",
"Language": "en",
"Country": "XG",
"Code": "Product Purpose"
}
]
}
}
]
}
