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"Inactive" } ] } ] }, "ProductSpec": [ { "ProductSpecVariant": { "Chapters": [ { "Name": "Storage Conditions (Product)", "Value": "Upon receipt and when not in use, store at 2-8°C. Do not freeze.", "Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Intended Use", "Value": "Glucagon Rabbit Polyclonal Primary Antibody is intended for laboratory use in the detection of the glucagon hormone in formalin-fixed, paraffin-embedded tissue stained on VENTANA BenchMark IHC/ISH instruments. This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls. This antibody is intended for in vitro diagnostic (IVD) use.", "Language": "en", "Country": "XG", "Code": "Intended Use" }, { "Name": "Content", "Value": "One dispenser of this antibody contains sufficient prediluted reagent for 50 tests.", "Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Background Information", "Value": "Pancreatic islets (islets of Langerhans) contain several cell types, including glucagon secreting alpha cells and insulin secreting beta cells, that work together to maintain glucose homeostasis.^1-2 Glucagon is a peptide hormone that increases blood glucose through gluconeogenesis and glycogenolysis^.1-3 Anti-glucagon labels glucagon secreting cells of both normal and neoplastic origin.

1. Quesada I, et al. Physiology of the pancreatic alpha-cell and glucagon secretion: role in glucose homeostasis and diabetes. J Endocrinol. 2008; 199:5-19.
2. Gurlo T, et al. Evaluation of immunohistochemical staining for glucagon in human pancreatic tissue. J Histotechnol. 2016; 39:8-16.
3. Wewer Albrechtsen NJ, et al. The biology of glucagon and the consequences of hyperglucagonemia. Biomark Med. 2016; 10:1141-51.", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Principle", "Value": "Glucagon Rabbit Polyclonal Antibody (this antibody) may be used as the primary antibody\nfor immunohistochemical staining of formalin-fixed, paraffin-embedded tissue sections. In\ngeneral, immunohistochemical staining allows the visualization of antigens via the sequential\napplication of a specific antibody (primary antibody) to the antigen, a secondary antibody\n(link antibody) to the primary antibody, an enzyme complex and a chromogenic substrate\nwith interposed washing steps. The enzymatic activation of the chromogen results in a visible\nreaction product at the antigen site. The specimen may then be counterstained and a coverslip\napplied. Results are interpreted using a light microscope and aid in the differential diagnosis\nof pathophysiological processes, which may or may not be associated with a particular\nantigen.\n
\n
\nThis antibody is optimally diluted to be compatible with VENTANA detection kits and\nBenchMark IHC/ISH instruments. Refer to the Tables in the Instructions for Use section for\nrecommended staining protocols. Each step in the staining protocol includes incubation for\na precise time at a specific temperature. At the end of each incubation step, the sections are\nrinsed by the BenchMark IHC/ISH instruments to stop the reaction and remove unbound\nmaterial that would hinder the desired reaction in subsequent steps. To minimize evaporation\nof the aqueous reagents from the specimen-containing slide, a coverslip solution is applied\nin the slide stainer. For more detailed information on instrument operation, refer to the\nappropriate BenchMark IHC/ISH instruments Operator’s Manual.", "Language": "en", "Country": "XG", "Code": "Principle" }, { "Name": "Product Purpose", "Value": "Glucagon Rabbit Polyclonal Primary Antibody is intended for laboratory use in the detection of the glucagon hormone in formalin-fixed, paraffin-embedded tissue stained on VENTANA BenchMark IHC/ISH instruments. This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls. This antibody is intended for in vitro diagnostic (IVD) use.", "Language": "en", "Country": "XG", "Code": "Product Purpose" } ] } } ] }