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"Name": "Storage Conditions (Product)",
"Value": "Upon receipt and when not in use, store at 2-8°C. Do not freeze.",
"Language": "en",
"Country": "XG",
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"Name": "Intended Use",
"Value": "Glucagon Rabbit Polyclonal Primary Antibody is intended for laboratory use in the detection of the glucagon hormone in formalin-fixed, paraffin-embedded tissue stained on VENTANA BenchMark IHC/ISH instruments. This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls. This antibody is intended for
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"Name": "Background Information",
"Value": "Pancreatic islets (islets of Langerhans) contain several cell types, including glucagon secreting alpha cells and insulin secreting beta cells, that work together to maintain glucose homeostasis.
1-2 Glucagon is a peptide hormone that increases blood glucose through gluconeogenesis and glycogenolysis
.1-3 Anti-glucagon labels glucagon secreting cells of both normal and neoplastic origin.
1. Quesada I, et al. Physiology of the pancreatic alpha-cell and glucagon secretion: role in glucose homeostasis and diabetes. J Endocrinol. 2008; 199:5-19.
2. Gurlo T, et al. Evaluation of immunohistochemical staining for glucagon in human pancreatic tissue. J Histotechnol. 2016; 39:8-16.
3. Wewer Albrechtsen NJ, et al. The biology of glucagon and the consequences of hyperglucagonemia. Biomark Med. 2016; 10:1141-51.",
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