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Mesothelin (MSLN) is a 40-kDa membrane bound cell surface glycoprotein that is largely restricted to normal mesothelial cells lining the pleura, pericardium, and peritoneum.1-4
The biological function of MSLN is unknown, though it has been observed that the protein has limited distribution on normal tissues and high expression in pancreatic cancer, ovarian cancer, mesothelioma, and other cancers.5
1. Chang K, Pai LH, Batra JK, Pastan I, Willingham MC. Characterization of the antigen (CAK1) recognized by monoclonal antibody K1 present on ovarian cancers and normal mesothelium. Cancer Res. 1992;52(1):181-6.
2. Chang K, Pastan I. Molecular cloning and expression of a cDNA encoding a protein detected by the K1 antibody from an ovarian carcinoma (OVCAR-3) cell line. Int J Cancer. 1994;57(1):90-7.
3. Chang K, Pastan I. Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers. Proc Natl Acad Sci USA. 1996;93(1):136-40.
4. Chowdhury PS, Viner JL, Beers R, Pastan I. Isolation of a high-affinity stable single-chain Fv specific for mesothelin from DNA-immunized mice by phage display and construction of a recombinant immunotoxin with anti-tumor activity. Proc Natl Acad Sci USA. 1998;95(2):669-74.
5. Pastan I, Hassan R. Discovery of mesothelin and exploiting it as a target for immunotherapy. Cancer Res. 2014;74(11):2907-12.",
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The antibody is diluted in phosphate buffered saline, 0.01 M EDTA, 0.05% Brij-35 with 0.3% carrier protein.
Total protein concentration of the reagent is approximately 3 mg/mL. Specific antibody concentration is approximately 1 μg/mL.
VENTANA MSLN (SP74) Assay is a Protein A purified recombinant rabbit monoclonal antibody.
Refer to the appropriate VENTANA detection kit package insert for detailed descriptions of: Principle of the Procedure, Material and Methods, Specimen Collection and Preparation for Analysis, Quality Control Procedures, Troubleshooting, Interpretation of Results, and General Limitations.",
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