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Do not freeze.", "Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Content", "Value": "VENTANA pan-TRK (EPR17341) Assay contains sufficient reagent for 50 tests.

One 5 mL dispenser of VENTANA pan-TRK (EPR17341) Assay contains approximately 140 μg of a rabbit monoclonal antibody.

The antibody is diluted in 0.05 M Tris buffered saline, 0.01 M EDTA, 0.05% Brij-35 with 0.3% carrier protein and 0.05% sodium azide, a preservative.
Total protein concentration of the reagent is approximately 10 mg/mL.
Specific antibody concentration is approximately 28 μg/mL. There is no known non-specific antibody reactivity observed in this product.
VENTANA pan-TRK (EPR17341) Assay is produced as a Protein A purified recombinant rabbit monoclonal antibody.

Refer to the OptiView DAB IHC Detection Kit package insert for detailed descriptions of: Principle of the Procedure, Material and Methods, Specimen Collection and Preparation for Analysis, Quality Control Procedures, Troubleshooting, Interpretation of Results, and General Limitations.", "Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Intended Use", "Value": "VENTANA pan-TRK (EPR17341) Assay is intended for laboratory use in the qualitative immunohistochemical detection of the C-terminal region of the tropomyosin receptor kinase (TRK) proteins A, B and C by light microscopy in sections of formalin-fixed, paraffin-embedded tissue stained on a BenchMark IHC/ISH instrument.

This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls.

This antibody is intended for in vitro diagnostic (IVD) use.", "Language": "en", "Country": "XG", "Code": "Intended Use" }, { "Name": "Background Information", "Value": "VENTANA pan-TRK (EPR17341) Assay is a rabbit monoclonal primary antibody directed against the C-terminal region of TRK A, B and C proteins, also known as pan-TRK. The TRK family is composed of three transmembrane protein receptors (TRKA, TRKB, TRKC) that are encoded by the neurotrophic receptor tyrosine kinase (NTRK) genes (NTRK1, NTRK2, NTRK3), respectively.^1-5The sequence of these TRK family members are highly conserved but they are activated by different neurotrophins.^1,2,3 In normal physiology, TRK receptors are preferentially expressed in tissues of neural origin and help regulate cell differentiation and survival; they also play a physiological role in the development of the central and peripheral nervous systems.^1-4
NTRK gene alterations, including point mutations, splice variants, amplification, and fusions, are detected in various tumor types.^1-5 Chimeric fusions involving NTRK1, NTRK2, or NTRK3 are the most common of these NTRK alterations.^1-5There are over 80 NTRK fusions reported and chimeric partners include ETV6, EML4, LMNA, and TPM3.^1,2,3 The results of these fusion events are oncogenes that are aberrantly expressed.^1-5 Preservation of the TRK kinase domain in these NTRK fusions drive carcinogenesis through constitutive activation of pathways that regulate cell survival, proliferation, invasion, and angiogenesis.^1-5
Wild-type TRK protein expression in most solid tumors is generally minimal and of low prevalence.^4,5 However, wild-type TRK protein expression can be substantial in some neuroendocrine tumor tissues.^4,5 Conversely, detection of chimeric NTRK fusion cases is rare and their variable prevalence across numerous tumor types (< 0.5-1.0% of cancers overall) has made it challenging to detect TRK fusion proteins.^4-8Thus, due to the nondiscriminatory nature of pan-TRK IHC in the detection of wild-type and chimeric TRK proteins, tumors displaying any positivity should be further characterized by a molecular and/or cytogenetic method to determine NTRK status.^5,7,8
Staining with the VENTANA pan-TRK (EPR17341) Assay was observed in multiple localizations (nuclear, cytoplasmic and membranous).

1. Khotskaya YB, Holla VR, Farago AF, et al. Targeting TRK Family Proteins in Cancer. Pharmacol Ther. 2017;173:58-66.
2. Cocco E, Scaltriti M, Drilon A. NTRK Fusion-Positive Cancers and TRK Inhibitor Therapy. Nat Rev Clin Oncol. 2018;15(12):731-747.
3. Amatu A, Sartore-Bianchi A, Bencardino K, et al. Tropomyosin Receptor Kinase (TRK) Biology and the Role of NTRK Gene Fusions in Cancer. Annals of Oncology. 2019;30:VIII5-VIII15.
4. Wong D, Yip S, Sorensen PH. Methods for Identifying Patients with Tropomyosin Receptor Kinase (TRK) Fusion Cancer. Pathol Oncol Res. 2020;26(3):1385-1399.
5. Solomon JP, Benayed R, Hechtman JF, et al. Identifying Patients with NTRK Fusion Cancer. Annals of Oncology. 2019;30:VIII16-VIII22.
6. Kummar S, Lassen UN. TRK Inhibition: A New Tumor-Agnostic Treatment Strategy. Target Oncol. 2018;13(5):545-556.
7. Hsiao SJ, Zehir A, Sireci AN, et al. Detection of Tumor NTRK Gene Fusions to Identify Patients Who May Benefit from Tyrosine Kinase (TRK) Inhibitor Therapy. J Mol Diagn. 2019;21(4):553-571.
8. Marchio C, Scaltriti M, Ladanyi M, et al. ESMO Recommendations on the Standard Methods to Detect NTRK Fusions in Daily Practice and Clinical Research. Ann Oncol. 2019;30(9):1417-1427.", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Principle", "Value": "VENTANA pan-TRK (EPR17341) Assay binds to the TRK epitope in n formalin-fixed, paraffin-embedded (FFPE) tissue sections. The specific antibody can be visualized using OptiView DAB IHC Detection Kit (Cat. No. 760-700 / 06396500001). Refer to the OptiView DAB IHC Detection Kit method sheet for further information.", "Language": "en", "Country": "XG", "Code": "Principle" }, { "Name": "Product Purpose", "Value": "VENTANA pan-TRK (EPR17341) Assay is intended for laboratory use in the qualitative immunohistochemical detection of the C-terminal region of the tropomyosin receptor kinase (TRK) proteins A, B and C by light microscopy in sections of formalin-fixed, paraffin-embedded tissue stained on a BenchMark IHC/ISH instrument.

This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls.

This antibody is intended for in vitro diagnostic (IVD) use.", "Language": "en", "Country": "XG", "Code": "Product Purpose" } ] } } ] }

VENTANA pan-TRK (EPR17341) Assay

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