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}, "ProductSpec": [ { "ProductSpecVariant": { "Chapters": [ { "Name": "Storage Conditions (Product)", "Value": "Upon receipt and when not in use, store at 2-8°C. Do not freeze.", "Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Content", "Value": "One dispenser of this antibody contains sufficient prediluted reagent for 50 tests.", "Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Intended Use", "Value": "TAG-72 (B72.3) Mouse Monoclonal Primary Antibody is intended for laboratory use in the detection of the TAG-72 glycoprotein in formalin-fixed, paraffin-embedded tissue stained on VENTANA BenchMark IHC/ISH instruments. This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls. This antibody is intended for in vitro diagnostic (IVD) use.", "Language": "en", "Country": "XG", "Code": "Intended Use" }, { "Name": "Background Information", "Value": "Tumor associated glycoprotein (TAG)-72 is a high molecular weight glycoprotein that is present on the surface of many neoplastic cells, including adenocarcinomas of the breast, colon, and lung.1-5 TAG-72 is found in lung adenocarcinoma and is absent in mesothelioma, making the TAG-72 antibody useful in distinguishing adenocarcinoma from mesothelioma.5

1. Thor A, et al. Distribution of oncofetal antigen tumor-associated glycoprotein-72 defined by monoclonal antibody B72.3. Cancer Res.1986; 46:3118-24.
2. Johnston WW, et al. Use of a monoclonal antibody (B72.3) as a novel immunohistochemical adjunct for the diagnosis of carcinomas in fine needle aspiration biopsy specimens. Hum Pathol. 1986; 17:501-13.
3. Lundy J, et al. Monoclonal antibody B72.3 as a diagnostic adjunct in fine needle aspirates of breast masses. Ann Surg. 1986; 203:399-402.
4. Kline TS, et al. Monoclonal antibody B72.3. An adjunct for evaluation of suspicious aspiration biopsy cytology from the breast. Cancer. 1989; 63:2253-56.
5. Ordóñez NG. Am J Surg Pathol. The immunohistochemical diagnosis of mesothelioma: a comparative study of epithelioid mesothelioma and lung adenocarcinoma. 2003; 27:1031-51.", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Principle", "Value": "TAG-72 (B72.3) Mouse Monoclonal Antibody (this antibody) may be used as the primary\nantibody for immunohistochemical staining of formalin-fixed, paraffin-embedded tissue\nsections. In general, immunohistochemical staining allows the visualization of antigens\nvia the sequential application of a specific antibody (primary antibody) to the antigen, a\nsecondary antibody (link antibody) to the primary antibody, an enzyme complex and a\nchromogenic substrate with interposed washing steps. The enzymatic activation of the\nchromogen results in a visible reaction product at the antigen site. The specimen may then be\ncounterstained and a coverslip applied. Results are interpreted using a light microscope and\naid in the differential diagnosis of pathophysiological processes, which may or may not be\nassociated with a particular antigen.\n
\n
\nThis antibody is optimally diluted to be compatible with VENTANA detection kits and\nBenchMark IHC/ISH instruments. Refer to the Tables in the Instructions for Use section for\nrecommended staining protocols. Each step in the staining protocol includes incubation for\na precise time at a specific temperature. At the end of each incubation step, the sections are\nrinsed by the BenchMark IHC/ISH instruments to stop the reaction and remove unbound\nmaterial that would hinder the desired reaction in subsequent steps. To minimize evaporation\nof the aqueous reagents from the specimen-containing slide, a coverslip solution is applied\nin the slide stainer. For more detailed information on instrument operation, refer to the\nappropriate BenchMark IHC/ISH instruments Operator’s Manual.", "Language": "en", "Country": "XG", "Code": "Principle" }, { "Name": "Product Purpose", "Value": "TAG-72 (B72.3) Mouse Monoclonal Primary Antibody is intended for laboratory use in the detection of the TAG-72 glycoprotein in formalin-fixed, paraffin-embedded tissue stained on VENTANA BenchMark IHC/ISH instruments. This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls. This antibody is intended for in vitro diagnostic (IVD) use.", "Language": "en", "Country": "XG", "Code": "Product Purpose" } ] } } ] }

TAG-72 (B72.3) Mouse Monoclonal Antibody

IVD For in vitro diagnostic use.
TAG-72 (B72.3) Mouse Monoclonal Antibody

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