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"Value": "CONFIRM anti-Vimentin (V9) antibody contains sufficient reagent for 50 tests.
One 5 mL dispenser of CONFIRM anti-Vimentin (V9) antibody contains approximately 12.5 μg of a mouse monoclonal antibody.
The antibody is diluted in aTris buffer containing carrier protein and preservative.
Specific antibody concentration is approximately 2.5 μg/mL.
There is no known non-specific antibody reactivity observed in this product.",
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This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and propper controls.
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"Value": "Vimentin, a 57 kDa type III intermediate filament protein encoded by the VIM gene, is located on chromosome 10 (10p13).1 Vimentin is the primordial intermediate filament protein expressed during embryogenesis, throughout which it functions to modulate cell formation and mitochondrial movement, provide structure to signaling molecules, and mediate signaling pathways.1,2,3 Vimentin is predominantly expressed in mesenchymal cells and the majority of tissues including, lymphoid tissues, astrocytes, adipocytes, epidermal cells, and glandular cells.1,3,4 Under normal physiological conditions, the primary function of vimentin is to control cellular shape, architecture, adhesion, migration, signaling, and motility.2,4,5 Vimentin also acts as a marker of epithelial-mesenchymal transition (EMT), a critical process for regulating tissue regeneration, inflammatory responses, and cellular differentiation.2,4,5 Overexpression of vimentin during EMT is associated with malignant transformation, tumor dissemination, and metastases.2,4,5
Vimentin is a broad mesenchymal marker that is expressed by virtually all mesenchymal neoplasms, regardless of histologic subtype, although it is not considered to be a cell lineage specific marker.3,6,7 Vimentin is widelyexpressed in sarcomas, lymphomas, melanoma, and some carcinomas.8,9 Among carcinomas, vimentin is typically expressed in clear cell, papillary, collecting duct, and unclassified renal cell carcinoma andis generally absentin chromophobe renal cell carcinoma.3,10 Furthermore, because vimentin expression is not lineagespecific it is typically evaluated as part of a panel of immunohistochemistry (IHC) studies that include other lineage markers.
The detection of vimentin by IHC with the CONFIRM anti-Vimentin(V9)Primary Antibody (CONFIRM anti-Vimentin (V9) antibody) may be used as an aid in the identification of sarcomas and as an aid in the diagnosis and subclassification of renal cell carcinoma. The cellular staining pattern for CONFIRM anti-Vimentin (V9) antibody is cytoplasmic.
1. Goldblum JR, Weiss SW, Folpe AL. Enzinger and Weiss's Soft Tissue Tumors E- Book. Elsevier Health Sciences; 2013.
2. Ridge KM, Shumaker D, Robert A, et al. Methods for Determining the Cellular Functions of Vimentin Intermediate Filaments. Methods Enzymol. 2016;568:389- 426.
3. Dabbs DJ. Diagnostic Immunohistochemistry Theranostic and Genomic Applications, 5th Edition. Vol 5. Amsterdam, Netherlands: Elsevier; 2019.
4. Danielsson F, Peterson MK, Caldeira Araújo H, et al. Vimentin Diversity in Health and Disease. Cells. 2018;7(10).
5. Sharma P, Alsharif S, Fallatah A, et al. Intermediate Filaments as Effectors of Cancer Development and Metastasis: A Focus on Keratins, Vimentin, and Nestin. Cells. 2019;8(5):497.
6. International Agency for Research on Cancer. WHOClassification of Tumours of Soft Tissue and Bone. 5th ed (Fletcher CDM ed.). IARC; 2020.
7. Heim-Hall J, Yohe SL. Application of Immunohistochemistry to Soft Tissue Neoplasms. Arch Pathol Lab Med. 2008;132(3):476-489.
8. Lin F, Liu H. Immunohistochemistry in Undifferentiated Neoplasm/Tumor of Uncertain Origin. Arch Pathol Lab Med. 2014;138(12):1583-1610.
9. Miettinen M, Lehto VP, Badley R, et al. Expression of Intermediate Filaments in Soft‐ Tissue Sarcomas. Int J Cancer. 1982;30(5):541-546.
10. Akgul M, Cheng L. Immunophenotypic and Pathologic Heterogeneity of Unclassified Renal Cell Carcinoma: A Study of 300 Cases. Hum Pathol. 2020;102:70-78.",
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{
"Name": "Product Purpose",
"Value": "CONFIRM anti-Vimentin (V9) Primary Antibody is intended for laboratory use in thequalitative immunohistochemical detection of vimentin by light microscopy in sections of formalin-fixed, paraffin-embedded tissue stained on a BenchMark IHC/ISH instrument.
This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and propper controls.
This antibody is intended for in vitro diagnostic (IVD) use.",
"Language": "en",
"Country": "XG",
"Code": "Product Purpose"
}
]
}
}
]
}
