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Elecsys® Phospho-Tau (181P) CSF

Robust and accurate biomarker tests to solve clinical questions

Elecsys® Phospho-Tau (181P) CSF

Robust and accurate biomarker tests to solve clinical questions

Elecsys® Phospho-Tau (181P) CSF (pTau) is an in vitro diagnostic immunoassay intended for the quantitative determination of the phosphorylated tau protein concentration in human cerebrospinal fluid (CSF).1

Elecsys® pTau assay is part of the Elecsys® AD portfolio, along with Elecsys® β-Amyloid(1-42) CSF II (AB42 2)  and Elecsys® Total-Tau CSF (tTau) immunoassays.1

Elecsys® AD CSF assays can detect amyloid positivity, enhancing diagnostic accuracy and physician confidence.2,3

Elecsys® AD CSF assays enable timely intervention by identifying patients with MCI at risk of progression to AD.1,3

HCPs at computer

The Power of Elecsys® in Alzheimer’s disease

Robust, clinically validated results to help ensure patients get the care they deserve

Elecsys® Phospho-Tau (181P) CSF test characteristics

  • Testing time

    18 minutes

  • Test principle

    Two-step sandwich 

  • Calibration

    2-point

  • Sample material

    Cerebrospinal Fluid (CSF)

  • Sample volume

    30 µL - cobas e 801 analytical unit and cobas e 402 analytical unit
    50 µL - cobas e 411 analyzer and cobas e 601/602 modules

  • LoB (Limit of Blank)

    4 pg/mL

  • LoD (Limit of Detection)

    8 pg/mL

  • LoQ (Limit of Quantitation)

    8 pg/mL

  • Measuring range

    8 – 120 pg/mL

  • Reagent onboard-stability

    28 days - cobas e 801 analytical unit and cobas e 402 analytical unit
    16 weeks - cobas e 411 analyzer and cobas e 601/602 modules

References

  1. Elecsys® β-Amyloid (1-42) CSF II E1G (Mat. No. 08821909500V1.0) method sheet, v1.0  2021-03;  Elecsys® β-Amyloid (1-42) CSF II E2G (Mat. No. 08821941500V1.0) method sheet, v1.0  2021-03; Elecsys® Phospho-Tau (181P) CSF II E1G  (Mat. No. 088466935001.0) method sheet, v1.0  2021-03;  Elecsys® Phospho-Tau (181P) CSF II E2G (Mat. No. 088467155001.0) method sheet, v1.0  2021-03; Elecsys® Total-Tau CSF CSF II E1G (Mat. No.08846634500 1.0) method sheet, v1.0  2021-03; Elecsys® Total-Tau CSF CSF II E2G (Mat. No. 088466855001.0) method sheet, v1.0  2021-03
  2. Hazan J, et al. (2023) Clinical utility of cerebrospinal fluid biomarkers in the evaluation of cognitive impairment: a systematic review and meta-analysis. J Neurol Neurosurg Psychiatry. 94(2):113-120. doi: 10.1136/jnnp-2022-329530. Epub 2022 Sep 12. PMID: 36096664.
  3. Hansson, O. et al. (2018). CSF biomarkers of Alzheimer’s disease concord with amyloid-β PET and predict clinical progression: A study of fully automated immunoassays in BioFINDER and ADNI cohorts. Alzheimers Dement 14(11), 1470-1481