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NGS panels designed by experts enable fast and efficient targeted sequencing
In many biomedical research settings, targeted next-generation sequencing (NGS) offers several advantages over whole-genome sequencing (WGS). For example, the use of NGS panels for enrichment of specific genomic regions can:
- Reduce sequencing costs while enabling deeper sequencing, as specific regions of interest can be interrogated with greater depth for higher sensitivity
- Simplify both computational analysis and data storage, as NGS panels yield more focused data and less data from other genomic regions.
However, NGS panel design can be complex and time-consuming, requiring several rounds of design and experimental trial-and-error to sufficiently and consistently cover the desired region. To make it easier for researchers to get started with targeted NGS without designing new panels, Roche offers predesigned NGS panels for both of our NGS target enrichment workflows: the hybridization-based KAPA HyperCap Workflow and the KAPA HyperPETE workflows, which uses primer-extension target enrichment.
We offer two types of predesigned panels to reduce the effort and expense needed to perform targeted NGS:
- Catalog Panels - designed by expert scientists, with in-house analytical validation, and supplied from stock
- Design Share Panels - developed in collaboration with leading scientists around the world, and customizable through the use of Roche’s HyperDesign Tool
And, if you do want to design your own panels, the online HyperDesign Tool is a free, easy-to-use, flexible NGS panel design tool that lets you create your own panels from scratch.
Featured products
RUO
For Research Use Only. Not for use in diagnostic procedures.
KAPA HyperCap Catalog Panels and Kits
KAPA HyperCap Catalog Panels are gene panels for target enrichment research use cases that combine targeted interrogation of genes with sequencing efficiency.
RUO
For Research Use Only. Not for use in diagnostic procedures.
KAPA HyperPETE Catalog Panels and Kits
The KAPA HyperPETE Catalog Panels are fixed-design panels for specific research areas, utilizing the novel KAPA HyperPETE hybrid-capture technology.
RUO
For Research Use Only. Not for use in diagnostic procedures.
Design Share Panels
Design Share panels are NGS Target Enrichment designs developed by Roche scientists and in collaboration with leading researchers around the world.
Benefits of predesigned NGS panel solutions from Roche
Expertly designed
High-confidence sequencing is enabled by expertly designed NGS panels
Designing a new sequencing panel can be overwhelming for researchers new to targeted sequencing or a specific workflow. Eliminate the guesswork with Roche’s predesigned NGS panels.
Our panels are designed by expert scientists who leverage a sophisticated algorithm built on over a decade of probe design expertise. Every new probe design undergoes rigorous in silico design and optimization to meet key performance metrics for the intended workflow. This process guarantees that our NGS panel content is relevant, current, and provides adequate coverage of targeted genomic regions of interest.
Reliable
Robust design for reliable target coverage in targeted NGS applications
While panel design is critical to ensure that all of the genes/regions of interest are uniformly covered, probe quality is just as important in ensuring robust and reproducible sequencing results.
Predesigned Roche sequencing panels are extensively tested, either in-house at Roche and/or by external collaborators. This ensures high on-target rates and coverage metrics, as well as accurate and sensitive mutation detection.
Every batch of Catalog Panel probes is subjected to NGS-based quality control (QC) testing to confirm probe presence and concentration.
Fast
Predesigned, validated NGS panels reduce implementation and ordering times
The time required to design, optimize, validate, and implement a new NGS panel can range from weeks to months, and probe manufacturing can add days to weeks to the total turnaround time if an existing panel is not available in the lab.
By selecting a predesigned Catalog or Design Share Panel, the time from panel design to implementation can be reduced significantly. Catalog Panels are supplied from stock. Therefore, lead times are similar to those for the other reagents required for your KAPA HyperCap or KAPA HyperPETE workflow.
Single-vendor support for the entire workflow simplifies the ordering process and inventory management.
Predesigned NGS panels comparison overview*
KAPA HyperCap Catalog Panels and Kits
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KAPA HyperPETE Catalog Panels and Kits
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Design Share Panels
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| Panel design done by | |||
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Roche
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Roche
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Roche and/or collaborator
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| Supplied from stock (where available) | |||
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Yes
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Yes
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No
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| Can be customized before ordering | |||
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No
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No
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Yes, using the HyperDesign Tool**
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*Not all Custom and Design Share Panels are currently available in all countries/regions.
** Accessed via https://www.hyperdesign.com
KAPA products are for Research Use Only, not for use in diagnostics procedures.