MagNA Pure 24 System

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IVD For in vitro diagnostic use.
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Effortless purification, confidence from automation
  • Proven performance delivering reproducible and consistent yields
  • Scalable extraction of 1-24 samples with primary sample handling in just over an hour
  • A single universal reagent kit covering 10 human sample types with volume inputs ranging 200 µL to 4 mL
  • Full traceability with inventory and sample tracking via barcoded surveillance
  • True walkaway automation
  • Contamination prevention with built-in UV lamp and CO-RE Tip technology


Prefilled, barcoded, and ready-to-use reagent kit


The universal MagNA Pure 24 Total Nucleic Acid Kit eliminates unnecessary complexity, enabling efficient extraction of nucleic acid from 10 prevalidated human sample types with one universal reagent kit. Reuse reagent cassettes for later use by sealing them and let the system identify and track reagent usage with on-board barcode scanning.


The flexibility to do more


The MagNA Pure 24 System gives you the flexibility to extract up to 10 different human sample types with a single universal reagent kit. Rely on this simplified reagent concept and choose one of the pre-optimized and pre-programmed protocols to extract from mixed batch sample types and primary tubes within one protocol.

Unlock the possibilities with
MagNA Pure 24 System

Efficiency made easy


The MagNA Pure 24 System isn’t just automated. It offers true walkaway operation with easy barcoded surveillance and minimal user interaction, so you can reduce human error and save valuable time.


  • Easy extraction set up
  • Intuitive and guided user interface on the built-in touch screen
  • Run the fast protocol for up to 8 samples in 30 minutes or less
  • Less than 30 second load check prior to a run
  • Fast instrument start up at the beginning of the day (<5 minutes)
  • Seamless data management via LIS connectivity
  • Fully automated FFPET sample extraction with deparaffinization and lysis on board


Confidence built right in


Confidence in your eluate is everything when it comes to molecular testing. The MagNA Pure 24 System is an IVD/CE-IVD instrument and comes with surveillance features to ensure the highest quality of eluate while reducing human error.


  • Contamination and safety control features
  • Barcoding capability to track sample ID and reagent usage
  • Cooling block to preserve eluates
  • Traceable software with audit management trail
  • Archiving data generated with system software; view archived data with the standalone archive viewer archive viewer on your PC
  • The Magna Pure 24 system is currently on software version 1.2
MagNA Pure 24 System
Registration status


Package inserts

Access package inserts through your country’s Roche Diagnostics website.


Ordering Information

Technical Documents

MagNA Pure 24 System protocols

The new MagNA Pure 24 System protocols package 3.0 are available for download from the table below (note: not available for download in the US).


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Target  Protocol name Input sample type and sample volumes
The latest version of MagNA Pure 24 protocols are available to download from the table below (not available in US)
 Elution volume  Run time♰ (h:mm)
 Whole blood  Plasma  Serum Nasal swabs*  BAL**
 Urine  Stool  Cultured cells Fresh-frozen tissue FFPET***
Bacterial, fungal and viral NA Pathogen 200  

Protocol optimized for speed

200 μL   50 or 100 μL 1:22
Fast Pathogen 200  

8 sample protocol optimized for speed, yield and purity

Pathogen 1000

Protocol optimized for yield and purity

500 or 1000 μl   1:40
External Lysis Pathogen 200
External Lysis Pathogen 500  

Protocols optimized with external lysis buffer

450 μl lysate from 200 μl sample
1450 μl lysate from 500 μl sample
Genomic DNA hgDNA 200  

Protocol optimized for human genomic NA

200 μl (≤ 2x106 cells)   Up to 5x105 Up to 5 mg   1:15
Fast hgDNA 200  

8 sample protocol optimized for speed

hgDNA ds 200  

Protocol optimized for NGS

hgDNA 1000  

Protocol optimized for yield and purity

500 μl (≤ 5x106 cells)
1000 μl (≤ 1x107 cells)
100 or 200 μl 2:25
Up to 1x106
DNA FFPET 1000  

Deparaffinization and lysis on board

  Up to 6 x 5 μm sections (up to 6 mm3) 50 or 100 μl 5:30
Cell-free NA cfNA ss 2000
cfNA ss 4000  

Protocol optimized for single-stranded DNA

  2000 μL   50 or 100 μL 2:05
4000 μL 3:00
cfNA ds 2000
cfNA ds 4000  

Protocol optimized for double-stranded DNA

  2000 μL   100, 150 or 200 μL 2:30
4000 μL 3:30
cfNA ds 4000 hp  

Protocol optimized for double-stranded DNA and NGS

  4000 μL   60 or 150 μL 4:40
Post elution Sample Transfer   to the processing cartridge 200 μL
500 μL
1000 μL
PCR Setup   for 2-25 μL per eluate for PCR Sstup in Frame-Strip with flat caps-Low Profile or LightCycler® 8-tube strips   0.05
Archiving   for 2-25 μL per eluate for PCR Sstup in FrameStrip low Profile strips or LightCycler® 8-tube strips 0.05
New Protocol
*Nasopharyngeal/nasal swabs
**BAL - Bronchoalveolar lavage
***FFPET - formalin-fixed paraffin-embedded tissue
♰These times are approximate and should only be used as a guidance.
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