Article

Sequencing by expansion data analysis resources

Published on January 20, 2026 | 2 min read

Enabling the future of NGS with SBX-optimized open-source (XOOS) analysis tools

Sequencing by expansion (SBX) is set to shape the future of NGS with the speed, accuracy, scalability and flexibility it offers. With the advent of this novel technology comes the need for tools equipped to maximize its value. Here you’ll find access to data sets, cutting edge analysis tools and supporting resources to enable the future of NGS.

The SBX technology and analysis tools are in development. The content of this material reflects current study results and/or design goals.

Access the data set

Create your account to access the whole genome sequencing SBX-D genome in a bottle (GIAB) data set.

Analysis tool resources

XOOS repository hosted by Roche on GitHub

XOOS small variant caller

XOOS analysis tools, including XOOS SVC, are hosted by Roche on Github

Visit XOOS repository

XOOS documentation hosted by Roche on GitBook

Analysis tool documentation

Supporting documentation for XOOS analysis tools, including XOOS SVC, is hosted by Roche on Gitbook.

Visit XOOS documentation

Github Deep Variant logo

DeepVariant model trained for SBX

Github repository for DeepVariant

Visit DeepVariant

Contributors

Omai Garner headshot

Roche Diagnostics

Roche Diagnostics is a division of Roche, developing and integrating diagnostic solutions that address today’s healthcare challenges while anticipating tomorrow’s needs. In more than 100 countries, we provide one of the industry’s most comprehensive in vitro diagnostics portfolios spanning molecular diagnostics, clinical chemistry and immunoassays, tissue diagnostics, Point of Care testing, patient self-testing, next-generation sequencing, laboratory automation and IT, as well as digital health and decision-support solutions.

Our articles are authored by Roche Diagnostics subject matter experts, drawing on collective expertise across multiple disciplines to provide reliable insights for healthcare professionals worldwide.

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