anti-CD117 (EP10) Rabbit Monoclonal Primary Antibody
Deliver diagnostic confidence in evaluation of GIST
Roche has designed a new Class 1 IVD, anti-CD117 (EP10) Rabbit Monoclonal Primary Antibody reagent for immunohistochemistry testing. anti-CD117 (EP10) is a ready-to-use IHC antibody that enables you to evaluate the expression of CD117 protein with confidence. The c-KIT gene encodes a transmembrane receptor tyrosine kinase (RTK). CD117 is present in a variety of normal human cell types, including breast epithelium, germ cells, melanocytes, immature myeloid cells and mast cells.1 Along with a panel of antibodies, CD117 immunohistochemistry may aid in the diagnosis of a range of diseases, including gastrointestinal stromal tumors (GISTs)2, mast cell disorders,2 and germ cell neoplasms.1-2
Literature describes the utility of CD117 in the differentiation of GISTs from other mesenchymal tumors along with other biomarkers, such as DOG1 and CD34.3-4