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1 SOX-10 is expressed in melanocytic lineages, and is a sensitive marker of melanoma for conventional, and desmoplastic subtypes.
2-3 In normal tissues, SOX-10 is expressed in melanocytes, and myoepithelial cells.
41. Rehberg S, et al. Sox10 is an active nucleocytoplasmic shuttle protein, and shuttling is crucial for Sox10-mediated transactivation. Mol Cell Biol. 2002; 22:5826-34.
2. Nonaka D, et al. Sox10: a pan-schwannian and melanocytic marker. Am J Surg Pathol. 2008; 32:1291-8.
3. Nielsen TO, et al. Sox10 and S100 in the diagnosis of soft-tissue neoplasms. Appl Immunohistochem Mol Morphol. 2012; 20:445-50.
4. Miettinen M, et al. Sox10--a marker for not only schwannian and melanocytic neoplasms but also myoepithelial cell tumors of soft tissue: a systematic analysis of 5134 tumors. Am J Surg Pathol. 2015; 39:826-35.",
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