anti-PRAME (EPR20330) Rabbit Monoclonal Primary Antibody

IHC Assay

IVD For in vitro diagnostic use.
Anti-PRAME (EPR20330) Rabbit Monoclonal Primary Antibody
Anti-PRAME (EPR20330) Rabbit Monoclonal Primary Antibody

PRAME (PReferentially expressed Antigen in MElanoma) is a tumor biomarker expressed in most cutaneous and ocular melanomas as well as various other malignant neoplasms.1

PRAME expression in formalin-fixed paraffin-embedded tissue is detected by immunohistochemistry and frequently demonstrates a diffuse nuclear immunostaining pattern in in situ and invasive melanoma. In contrast, the majority of benign melanocytic nevi lack nuclear PRAME staining.2

Studies suggest that detection of PRAME expression by immunohistochemistry (IHC) may complement findings from routinely used H&E and other IHC panels and aid in:

  • Differential diagnoses of benign versus malignant melanocytic lesions1,2
  • Evaluation of tumor margins in melanoma specimens1,2
  • Evaluation of sentinel lymph nodes in melanoma cases.3

References

  1. Lezcano, C. et al. PRAME expression in melanocytic tumors.  Am J Surg Pathol 2018;42(11):1456-1465.
  2. Lezcano, C. et al. PRAME immunohistochemistry as an ancillary test for the assessment of melanocytic lesions. Surg Pathol Clin 2021 Jun;14(2):165-175.
  3. Lezcano, C. et al. Immunohistochemistry for PRAME in the distinction of nodal nevi from metastatic melanoma. Am J Surg Pathol 2020;44(4):503-508.

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