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"Value": "VENTANA Basal Cell Cocktail (34βE12+p63) (Cat. No. 790-4536) contains sufficient reagent for 50 tests.
One 5 mL dispenser of VENTANA Basal Cell Cocktail (34βE12+p63) contains approximately 8 μg of a mouse antibody cocktail.
VENTANA Basal Cell Cocktail (34βE12+p63) (Cat. No. 790-1010) contains sufficient reagent for 250 tests. One 25 mL dispenser of VENTANA Basal Cell Cocktail (34βE12+p63) contains approximately 40 μg of a mouse antibody cocktail.
The antibody is diluted in Tris-HCl with carrier protein and ProClin 300, a preservative.
Specific antibody concentration is approximately 1.6 μ g/mL. There is no known non-specific antibody reactivity observed in this product.
VENTANA Basal Cell Cocktail (34β E12+p63) is a cocktail of mouse monoclonal antibodies produced from cell culture supernatant [anti-p63 (4A4)] and ascites [anti-keratin (34β E12)] material.
Refer to the appropriate VENTANA detection kit method sheet for detailed descriptions of: Principle of the Procedure, Material and Methods, Specimen Collection and Preparation for Analysis, Quality Control Procedures, Troubleshooting, Interpretation of Results, and Limitations.",
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"Value": "VENTANA Basal Cell Cocktail (34βE12+p63) is an antibody cocktail of anti-p63 (4A4) and anti-keratin (34βE12) mouse monoclonal antibodies. The human tumor protein 63 (TP63, p63) is a 77 kDa protein localized to the cellular nucleus and member of the p53 family of transcription factors.1 In the prostate, p63 is expressed in the basal cells of almost all normal and benign glands.2,3 Cytokeratin 5 is a 62 kDa type II high molecular weight cytokeratin expressed in basal cells and not luminal cells of the prostate.4,5 The 34βE12 antibody is commonly referred to as a basal cell high-molecular-weight-cytokeratin specific antibody. It recognizes cytokeratin 5, and by extension its in vivo partner cytokeratin 14, as well as cytokeratin 1 and its in vivo partner cytokeratin 10, which are not basal cell markers.4,6
In the prostate, p63 can be detected in the nucleus and cytokeratin 5 can be detected in the cytoplasm of basal cells from almost all normal and benign glands.2,3,4,5 Invasive lesions that evolve from and involve the prostate can disrupt and eventually breach the basal membrane thus eliminating the presence of prostatic basal cells.7 Thus, VENTANA Basal Cell Cocktail (34βE12+p63) may be used to detect basal cells to aid in the differentiation of benign and malignant prostate lesions.
This cocktail of antibodies has been reported to provide advantages in sensitivity over the use of anti-p63 (4A4) antibody or anti-keratin (34βE12) antibody alone in the detection of prostatic basal cells.8,9,10 In addition, a small percentage of normal or benign glands may express only one of these antigens. Thus, the two components of this cocktail not only augment, but also complement each other in basal cell detection.9
1. Yang A, Kaghad M, Wang Y, et al. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell. 1998;2:305-316.
2. Yang A, Schweitzer R, Sun D, et al. p63 Is Essential for Regenerative Proliferation in Limb, Craniofacial and Epithelial Development. Nature. 1999;398 (6729):714-718.
3. Signoretti S, Waltregny D, Dilks J, et al. p63 Is a Prostate Basal Cell Marker and Is Required for Prostate Development. American Journal of Pathology. 2000;157(6):1769-1775.
4. Moll R, Divo M, Langbein L. The Human Keratins: Biology and Pathology. Histochemistry and Cell Biology. 2008;129(6):705-733.
5. Yang Y, Hao J, Liu X, et al. Differential Expression of Cytokeratin mRNA and Protein in Normal Prostate, Prostatic Intraepithelial Neoplasia, and Invasive Carcinoma. American Journal of Pathology. 1997;150(2):693-704.
6. Gown AM, Vogel AM. Monoclonal Antibodies to Human Intermediate Filament Proteins. II. Distribution of Filament Proteins in Normal Human Tissues. American Journal of Pathology. 1984;114(2):309-321.
7. Epstein JI, Egevad L, Humphrey PA, et al. Best Practices Recommendations in the Application of Immunohistochemistry in the Prostate: Report from the International Society of Urologic Pathology Consensus Conference. Am J Surg Pathol. 2014;38(8):e6-e19.
8. Shah RB, Zhou M, LeBlanc M et al. Comparison of the basal cell-specific markers, 34βE12 and p63, in the diagnosis of prostate cancer Am J Surg Pathol. 2002;26:1161–1168.
9. Zhou M, Shah R, Shen R, et al. Basal Cell Cocktail (34βE12 + p63) improves the detection of prostate basal cells. Am J Surg Pathol. 2003;27:365–371.
10. Shah RB, Kunju LP, Shen R, et al. Usefulness of basal cell cocktail (34βE12 + p63) in the diagnosis of atypical prostate glandular proliferations. Am J Clin Pathol. 2004;122:517-523.",
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This antibody is intended for in vitro diagnostic (IVD) use.",
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This antibody is intended for in vitro diagnostic (IVD) use.",
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