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2-8°C. Do not freeze.", "Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Content", "Value": "One dispenser of this antibody contains sufficient prediluted reagent for 50 tests.", "Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Background Information", "Value": "Calcitonin (thyrocalcitonin) is a 32 amino acid linear polypeptide hormone that participates in calcium and phosphorus metabolism.¹ Immunohistochemical staining with anti-calcitonin antibody is an effective way of demonstrating calcitonin-producing parafollicular C cells in the thyroid.^2,3 Immunohistochemical studies of C-cell hyperplasia and medullary thyroid carcinomas stain will predominately stain positive for calcitonin.² Other tissues such as the lungs and intestinal tract can also synthesize calcitonin.¹ Expression of Calcitonin in both nonneoplastic and neoplastic neuroendocrine cells of these organs, such as carcinoids and small cell lung carcinomas, may be seen.⁴


1. Calcitonin. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainscalcitonin.html. Accessed May 3, 2017.
2. Matias-Guiu X, et al. Medullary thyroid carcinoma: a 25-year perspective. Endocr Pathol.2014; 25:21-9.
3. Fisher S, et al. Application of immunohistochemistry to thyroid neoplasms. Arch Pathol Lab Med. 2008;132:359-72.
4. Tsutsumi Y. Immunohistochemical analysis of calcitonin and calcitonin gene-related peptide in human lung. Hum Pathol. 1989; 20: 869-902.
 ", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Intended Use", "Value": "Calcitonin Rabbit Polyclonal Primary Antibody is intended for laboratory use in the detection of the calcitonin hormone in formalin-fixed, paraffin-embedded tissue stained on VENTANA BenchMark IHC/ISH instruments. This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls. This antibody is intended for in vitro diagnostic (IVD) use.", "Language": "en", "Country": "XG", "Code": "Intended Use" }, { "Name": "Principle", "Value": "Calcitonin Rabbit Polyclonal Antibody (this antibody) may be used as the primary antibody for immunohistochemical staining of formalin-fixed, paraffin-embedded tissue sections. In general, immunohistochemical staining allows the visualization of antigens via the sequential application of a specific antibody (primary antibody) to the antigen, a secondary antibody (link antibody) to the primary antibody, an enzyme complex and a chromogenic substrate with interposed washing steps. The enzymatic activation of the chromogen results in a visible reaction product at the antigen site. The specimen may then be counterstained and a coverslip applied. Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with a particular antigen.

This antibody is optimally diluted to be compatible with VENTANA detection kits and BenchMark IHC/ISH instruments. Refer to the Tables in the Instructions for Use section for recommended staining protocols. Each step in the staining protocol includes incubation for a precise time at a specific temperature. At the end of each incubation step, the sections are rinsed by the BenchMark IHC/ISH instruments to stop the reaction and remove unbound material that would hinder the desired reaction in subsequent steps. To minimize evaporation of the aqueous reagents from the specimen-containing slide, a coverslip solution is applied in the slide stainer. For more detailed information on instrument operation, refer to the appropriate BenchMark IHC/ISH instruments Operator’s Manual.", "Language": "en", "Country": "XG", "Code": "Principle" }, { "Name": "Product Purpose", "Value": "Calcitonin Rabbit Polyclonal Primary Antibody is intended for laboratory use in the detection of the calcitonin hormone in formalin-fixed, paraffin-embedded tissue stained on VENTANA BenchMark IHC/ISH instruments. This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls. This antibody is intended for in vitro diagnostic (IVD) use.", "Language": "en", "Country": "XG", "Code": "Product Purpose" } ] } } ] }