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2-8°C. Do not freeze.", "Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Content", "Value": "One dispenser of this antibody contains sufficient prediluted reagent for 50 tests.", "Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Background Information", "Value": "Calcitonin (thyrocalcitonin) is a 32 amino acid linear polypeptide hormone that participates in calcium and phosphorus metabolism.1 Immunohistochemical staining with anti-calcitonin antibody is an effective way of demonstrating calcitonin-producing parafollicular C cells in the thyroid.2,3 Immunohistochemical studies of C-cell hyperplasia and medullary thyroid carcinomas stain will predominately stain positive for calcitonin.2 Other tissues such as the lungs and intestinal tract can also synthesize calcitonin.1 Expression of Calcitonin in both nonneoplastic and neoplastic neuroendocrine cells of these organs, such as carcinoids and small cell lung carcinomas, may be seen.4


1. Calcitonin. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainscalcitonin.html. Accessed May 3, 2017.
2. Matias-Guiu X, et al. Medullary thyroid carcinoma: a 25-year perspective. Endocr Pathol.2014; 25:21-9.
3. Fisher S, et al. Application of immunohistochemistry to thyroid neoplasms. Arch Pathol Lab Med. 2008;132:359-72.
4. Tsutsumi Y. Immunohistochemical analysis of calcitonin and calcitonin gene-related peptide in human lung. Hum Pathol. 1989; 20: 869-902.
 ", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Intended Use", "Value": "Calcitonin Rabbit Polyclonal Primary Antibody is intended for laboratory use in the detection of the calcitonin hormone in formalin-fixed, paraffin-embedded tissue stained on VENTANA BenchMark IHC/ISH instruments. This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls. This antibody is intended for in vitro diagnostic (IVD) use.", "Language": "en", "Country": "XG", "Code": "Intended Use" }, { "Name": "Principle", "Value": "Calcitonin Rabbit Polyclonal Antibody (this antibody) may be used as the primary antibody for immunohistochemical staining of formalin-fixed, paraffin-embedded tissue sections. In general, immunohistochemical staining allows the visualization of antigens via the sequential application of a specific antibody (primary antibody) to the antigen, a secondary antibody (link antibody) to the primary antibody, an enzyme complex and a chromogenic substrate with interposed washing steps. The enzymatic activation of the chromogen results in a visible reaction product at the antigen site. The specimen may then be counterstained and a coverslip applied. Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with a particular antigen.

This antibody is optimally diluted to be compatible with VENTANA detection kits and BenchMark IHC/ISH instruments. Refer to the Tables in the Instructions for Use section for recommended staining protocols. Each step in the staining protocol includes incubation for a precise time at a specific temperature. At the end of each incubation step, the sections are rinsed by the BenchMark IHC/ISH instruments to stop the reaction and remove unbound material that would hinder the desired reaction in subsequent steps. To minimize evaporation of the aqueous reagents from the specimen-containing slide, a coverslip solution is applied in the slide stainer. For more detailed information on instrument operation, refer to the appropriate BenchMark IHC/ISH instruments Operator’s Manual.", "Language": "en", "Country": "XG", "Code": "Principle" }, { "Name": "Product Purpose", "Value": "Calcitonin Rabbit Polyclonal Primary Antibody is intended for laboratory use in the detection of the calcitonin hormone in formalin-fixed, paraffin-embedded tissue stained on VENTANA BenchMark IHC/ISH instruments. This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls. This antibody is intended for in vitro diagnostic (IVD) use.", "Language": "en", "Country": "XG", "Code": "Product Purpose" } ] } } ] }

Calcitonin Rabbit Polyclonal Antibody

IVD For in vitro diagnostic use.
Calcitonin Rabbit Polyclonal Antibody

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