For Research Use Only. Not for use in diagnostic procedures. Others CC1 DISCOVERY RUO DISCOVERY CC1 RTD000846 06414575001 DISC. CC1 RUO DISCOVERY CC1 04015630973989 Reagents, kits 950-500 2 L bottle Not Available true Ventana Medical Systems' (Ventana) DISCOVERY CC1 (DISCOVERY Cell Conditioning Solution) is a pre-diluted solution used as a pretreatment step in the processing of tissue samples for immunohistochemistry (IHC) reactions carried out on Ventana DISCOVERY XT and DISCOVERY ULTRA automated slide stainers. en Fixation of tissue by formalin results in the formation of covalent bonds between the aldehyde and amino groups present in the tissue. The formation of these bonds denatures protein and can result in the loss of antigenicity. In addition, the formaldehyde can form methylene bridges cross linking tissue proteins thus reducing the penetration of the tissue to large molecules such as antibodies.DISCOVERY CC1 is a Tris based buffer with a slightly basic pH, which at elevated temperatures is capable of hydrolyzing the covalent bonds formed by formalin in tissue. Removing these bonds allows renaturation of protein molecules and increases antibody accessibility. Often these changes result in significant gains in antibody binding and improved signal to noise ratios. The automated slide stainer automatically heats the slide to the appropriate temperature and time as selected by the user. en DISCOVERY CC1 is a Tris based buffer, which must not be diluted. en