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"Chapters": [
{
"Name": "Storage Conditions (Product)",
"Value": "Upon receipt and when not in use, store at 2-8°C. Do not freeze.",
"Language": "en",
"Country": "XG",
"Code": "Storage Conditions (Product)"
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{
"Name": "Background Information",
"Value": "VENTANA anti-CD10 (SP67) Rabbit Monoclonal Primary Antibody (VENTANA anti-CD10 (SP67) antibody) is a recombinant rabbit monoclonal antibody. CD10, or the common acute lymphoblastic leukemia antigen (CALLA), is a 90- to 110-KD integral membrane glycoprotein.1,2,3,4 As a peptidase, CD10 cleaves various substrates, lowers the extracellular concentrations of the substrates, and alters downstream signaling mechanisms.2,3 In the hematopoietic system, CD10 is normally expressed in early lymphoid cells, detected transiently during B-cell differentiation, especially in germinal center B-cells (GCB), but its expression is lost in mature B-cells.1,2,3,4,5 Detection of CD10 is useful in the characterization of a subset of malignant lymphomas, including B-cell acute lymphoblastic leukemia (B-ALL), and neoplasms derived from GCB such as diffuse large B-cell lymphoma, follicular lymphoma, and Burkitt lymphoma.1,2,3,4 Aside from B-cells, CD10 is also normally expressed in non-hematopoietic tissues such as the prostate, kidneys, intestines, and lungs.6,7,8 In particular, CD10 has been a useful marker to aid in the identification of some renal cell carcinomas such as clear cell renal cell carcinoma and papillary renal cell carcinoma.6,7,8
The detection of CD10 by immunohistochemistry (IHC) with VENTANA anti-CD10 (SP67) antibody may be used in the detection of CD10-positive B-cells to aid in the identification of B-acute lymphoblastic leukemia (B-ALL) and neoplasms derived from germinal center B-cell (GCB) origins and the detection of renal cells to aid in the classification of some renal cell carcinomas. This antibody may be used as part of a panel of IHC studies. The staining pattern is membranous and/or cytoplasmic.
1. O'Malley DP, Fedoriw Y, Grimm KE, et al. Immunohistology of Lymph Node and Lymph Node Neoplasms, 5th Edition. In: Dabbs DJ, ed. Diagnostic Immunohistochemistry. Elsevier 2019:160-202.
2. Mishra D, Singh S, Narayan G. Role of B Cell Development Marker CD10 in Cancer Progression and Prognosis. Mol Biol Int. 2016;2016:4328697.
3. Maguer-Satta V, Besancon R, Bachelard-Cascales E. Concise Review: Neutral Endopeptidase (CD10): A Multifaceted Environment Actor in Stem Cells, Physiological Mechanisms, and Cancer. Stem Cells. 2011;29(3):389-396.
4. Arber DA, Weiss LM. CD10: a review. Appl lmmunohisto M M 1997;5:125-140.
5. Chen B-J, Fend F, Campo E, et al. Aggressive B-Cell Lymphomas—from Morphology to Molecular Pathogenesis. Ann Lymphoma. 2019;3:1-1.
6. Shen SS, Truong LD, Scarpelli M, et al. Role of Immunohistochemistry in Diagnosing Renal Neoplasms: When Is It Really Useful? Arch Pathol Lab Med. 2012;136(4):410-417.
7. Truong LD, Shen SS. Immunohistochemical Diagnosis of Renal Neoplasms. Arch Pathol Lab Med. 2011;135(1):92-109.
8. Kuroda N, Tanaka A, Ohe C, et al. Recent Advances of Immunohistochemistry for Diagnosis of Renal Tumors. Pathol Int. 2013;63(8):381-390",
"Language": "en",
"Country": "XG",
"Code": "Background Information"
},
{
"Name": "Content",
"Value": "VENTANA anti-CD10 (SP67) antibody contains sufficient reagent for 50 tests.
One 5 mL dispenser of VENTANA anti-CD10 (SP67) antibody contains approximately 24.5 μg of a rabbit monoclonal antibody.
The antibody is diluted in phosphate buffered saline containing carrier protein and 0.05% ProClin 300 as a preservative.
Specific antibody concentration is approximately 4.9 μg/mL. There is no known nonspecific antibody reactivity observed in this product. VENTANA anti-CD10 (SP67) antibody is a recombinant monoclonal antibody produced from purified cell culture supernatant.
Refer to the appropriate VENTANA detection kit method sheet for detailed descriptions of: Principle of the Procedure, Material and Methods, Specimen Collection and Preparation for Analysis, Quality Control Procedures, Troubleshooting, Interpretation of Results, and Limitations.",
"Language": "en",
"Country": "XG",
"Code": "Content"
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{
"Name": "Intended Use",
"Value": "VENTANA anti-CD10 (SP67) Rabbit Monoclonal Primary Antibody is intended for laboratory use in the qualitative immunohistochemical detection of CD10 by light microscopy in sections of formalin-fixed, paraffin-embedded tissue stained on a BenchMark IHC/ISH instrument.
This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls.
This antibody is intended for in vitro diagnostic (IVD) use",
"Language": "en",
"Country": "XG",
"Code": "Intended Use"
},
{
"Name": "Principle",
"Value": "VENTANA anti-CD10 (SP67) antibody is a rabbit monoclonal antibody produced against a synthetic peptide corresponding to the human CD10 protein. VENTANA anti-CD10 (SP67) antibody binds to the CD10 protein in formalin-fixed, paraffin-embedded (FFPE) tissue sections and exhibits a membrane and/or cytoplasmic staining pattern. This antibody can be visualized using OptiView DAB IHC Detection Kit (Cat. No. 760-700 / 06396500001) or ultraView Universal DAB Detection Kit (Cat. No. 760-500 / 05269806001). Refer to the respective method sheet for further information.",
"Language": "en",
"Country": "XG",
"Code": "Principle"
},
{
"Name": "Product Purpose",
"Value": "VENTANA anti-CD10 (SP67) Rabbit Monoclonal Primary Antibody is intended for laboratory use in the qualitative immunohistochemical detection of CD10 by light microscopy in sections of formalin-fixed, paraffin-embedded tissue stained on a BenchMark IHC/ISH instrument.
This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls.
This antibody is intended for in vitro diagnostic (IVD) use",
"Language": "en",
"Country": "XG",
"Code": "Product Purpose"
}
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}
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}