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{
"Name": "Background Information",
"Value": "Anti-CD117 (EP10) Rabbit Monoclonal Primary Antibody [anti-CD117 (EP10) antibody] is a rabbit monoclonal primary antibody produced against CD117 (c-KIT), a tyrosine kinase growth factor receptor expressed in a variety of cell types.1 In humans, CD117 is encoded by KIT on chromosome 4 and is adjacent to the structurally similar gene for platelet derived growth factor receptor alpha (PDGFRA).2,3 The CD117 protein is an approximately 145 kDa transmembrane glycoprotein with an extracellular ligand binding domain and a two-part intracellular kinase domain.4 Under normal conditions, CD117 is activated by its ligand, stem cell factor, also known as mast cell growth factor.2 Activation of the tyrosine kinase domain of CD117 results in the phosphorylation of a variety of downstream transcription factors.2 This leads to the activation of multiple pathways involved in cellular proliferation,differentiation and apoptosis.2,5,6 CD117 can be detected using immunohistochemistry (IHC)-based assays in non-neoplastic and neoplastic tissues. CD117 expression is typically detected in the interstitial cells of Cajal (ICC), mast cells, breast ductal epithelial cells, and melanocytes.7,8,9 In neoplasms, alterations in KIT such as point mutations, in-frame deletions, and duplications can lead to CD117 overexpression and constitutive activation in the absence of stem cell factor.10 These CD117 alterations can promote tumorigenesis in a variety of tumors including gastrointestinal stromal tumors (GIST), seminoma, melanoma, a small subset of breast carcinomas, and small cell lung carcinoma.1 The IHC-based detection of CD117 using anti-CD117 (EP10) antibody, in combination with other markers, may be used to aid in the diagnosis of GIST, seminoma, and melanoma.
1. Miettinen M, Lasota J. KIT (CD117): a review on expression in normal and neoplastic tissues, and mutations and their clinicopathologic correlation. Appl Immunohistochem Mol Morphol. 2005;13(3):205-20.
2. Stankov K, Popovic S, Mikov M. C-Kit Signaling in Cancer Treatment. Curr Pharm Des. 2014;20(17):2849-2880.
3. Spritz RA, Strunk KM, Lee ST, et al. A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12. Genomics. 1994;22(2):431-6.
4. Pawson T. Regulation and targets of receptor tyrosine kinases. Eur J Cancer. 2002;38 Suppl 5:S3-10.
5. Kitamura Y, Hirotab S. Kit as a human oncogenic tyrosine kinase. Cell Mol Life Sci. 2004;61(23):2924-31.
6. Blume-Jensen P, Claesson-Welsh L, Siegbahn A, et al. Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis. EMBO J. 1991;10(13):4121-8.
7. Tsuura Y, Hiraki H, Watanabe K, et al. Preferential localization of c-kit product in tissue mast cells, basal cells of skin, epithelial cells of breast, small cell lung carcinoma and seminoma/dysgerminoma in human: immunohistochemical study on formalin-fixed, paraffin-embedded tissues. Virchows Arch. 1994;424(2):135-41.
8. Lammie A, Drobnjak M, Gerald W, et al. Expression of c-kit and kit ligand proteins in normal human tissues. J Histochem Cytochem. 1994;42(11):1417-25.
9. Huizinga JD, Thuneberg L, Kluppel M, et al. W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity. Nature. 1995;373(6512):347-9.
10. Miettinen M, Lasota J. Gastrointestinal stromal tumors (GISTs): definition, occurrence, pathology, differential diagnosis and molecular genetics. Pol J Pathol. 2003;54(1):3-24.",
"Language": "en",
"Country": "XG",
"Code": "Background Information"
},
{
"Name": "Principle",
"Value": "Anti-CD117 (EP10) antibody binds to CD117 (c-KIT) in formalin-fixed, paraffin-embedded (FFPE) tissue sections. The specific antibody can be visualized using the OptiView DAB IHC Detection Kit or the ultraView Universal DAB Detection Kit. Refer to the specific detection kit method sheet for further information.",
"Language": "en",
"Country": "XG",
"Code": "Principle"
},
{
"Name": "Content",
"Value": "Anti-CD117 (EP10) antibody contains sufficient reagent for 50 tests.
One 5 mL dispenser of anti-CD117 (EP10) antibody contains approximately 0.5 μg of a rabbit monoclonal antibody.
The antibody is diluted in Tris buffered saline, EDTA, Brij-35 with carrier protein and 0.05% sodium azide, a preservative.
Specific antibody concentration is approximately 0.1 μg/mL.
Anti-CD117 (EP10) antibody is a recombinant rabbit monoclonal antibody purified from cell culture supernatant.
Refer to the appropriate VENTANA detection kit method sheet for detailed descriptions of: Principle of the Procedure, Material and Methods, Specimen Collection and Preparation for Analysis, Quality Control Procedures, Troubleshooting, Interpretation of Results, and General Limitations.",
"Language": "en",
"Country": "XG",
"Code": "Content"
},
{
"Name": "Product Purpose",
"Value": "Anti-CD117 (EP10) Rabbit Monoclonal Primary Antibody is intended for laboratory use in the qualitative immunohistochemical detection of CD117 protein by light microscopy in sections of formalin-fixed, paraffin- embedded tissue stained on a BenchMark IHC/ISH instrument.
This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls.
This antibody is intended for in vitro diagnostic (IVD) use.",
"Language": "en",
"Country": "XG",
"Code": "Product Purpose"
}
]
}
}
]
}
