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Do not freeze.", "Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Content", "Value": "CONFIRM anti-CD15 (MMA) antibody contains sufficient reagent for staining 50 tests.

One 5 mL dispenser of CONFIRM anti-CD15 (MMA) antibody contains approximately 56 μg of a mouse monoclonal antibody.

The antibody is diluted in Tris-HCI with carrier protein, and 0.10% ProClin 300, a preservative.

Specific antibody concentration is approximately 11 μg/mL. There is no known nonspecific antibody reactivity observed in this product.

CONFIRM anti-CD15 (MMA) antibody is a mouse monoclonal antibody produced as a cell culture supernatant.

Refer to the appropriate VENTANA detection kit method sheet for detailed descriptions of: Principle of the Procedure, Material and Methods, Specimen Collection and Preparation for Analysis, Quality Control Procedures, Troubleshooting, Interpretation of Results, and Limitations.", "Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Intended Use", "Value": "CONFIRM anti-CD15 (MMA) Mouse Monoclonal Primary Antibody is intended for laboratory use in the qualitative immunohistochemical detection of CD15 by light microscopy in sections of formalin-fixed, paraffin-embedded tissue stained on a BenchMark IHC/ISH instrument.

This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls.

This antibody is intended for in vitro diagnostic (IVD) use.", "Language": "en", "Country": "XG", "Code": "Intended Use" }, { "Name": "Principle", "Value": "CONFIRM anti-CD15 (MMA) antibody binds to the CD15 protein in formalin-fixed, paraffin-embedded tissue (FFPE) sections and exhibits a membranous staining pattern. This antibody can be visualized using OptiView DAB IHC Detection Kit (Cat. No. 760-700 / 06396500001) or ultraView Universal DAB Detection Kit (Cat. No. 760-500 / 05269806001). Refer to the respective method sheet for further information.", "Language": "en", "Country": "XG", "Code": "Principle" }, { "Name": "Background Information", "Value": "CONFIRM anti-CD15 (MMA) Mouse Monoclonal Primary Antibody (CONFIRM anti-CD15 (MMA) antibody) recognizes lacto-N-fucopentaose III. CD15, also known as Lewis X (Lex) and stage-specific embryonic antigen-1 (SSEA-1), is a carbohydrate antigen expressed on glycolipids and glycoproteins that was first identified in mice, human milk, and some adenocarcinomas.^1,2 The antigen is formed through fucosylation, which is specifically directed by FUT4 (Fucosyltransferase 4) in promyelocytes and monocytes and FUT9 in granulocytes.³ Of note, a related epitope, sialyl-CD15, differs in structure and modifications present on the carbohydrate molecule, and antibodies that recognize one epitope do not recognize the other.⁴ Non-sialylated CD15 is involved in cell-cell adhesion and preferentially binds to P-selectin and E-selectin.^5,6 CD15 is also implicated in the activation of neutrophils and macrophages, a function that may be specific to the moiety of CD15 or selectins present.⁵

Antibodies against CD15 normally react in a strong cell surface membrane staining pattern with granulocytes and granulocyte precursors, monocytes, a subset of tissue macrophages, and activated T-lymphocytes.^4,7-11 The antigen is also expressed in activated B-cells and T-cells, follicular dendritic cells, Paneth cells, and neuroendocrine cells, and a wide range of epithelial tissues including, but not limited to, gastrointestinal tract, liver, pancreas, kidney, bladder, breast and salivary gland.^11-15

CD15 antigen is aberrantly expressed in Hodgkin/Reed-Sternberg cells in classic Hodgkin lymphoma and, therefore, is commonly used as part of a panel to confirm a classic Hodgkin lymphoma diagnosis.^7,9,13,16

The clinical application of the detection of CD15 by immunohistochemistry (IHC) with the CONFIRM anti-CD15 (MMA) antibody is as an aid in the diagnosis of classic Hodgkin lymphoma.

1. Kobata A, Ginsburg V. Oligosaccharides of Human Milk II. Isolation And Characterization Of A New Pentasaccharide, Lacto-N-Fucopentaose III. The Journal of Biological Chemistry. 1969;244(20):5496-5502.
2. Yang HJ, Hakomori SI. A Sphingolipid Having A Novel Type of Ceramide And Lacto-N-Fucopentaose. The Journal of Biological Chemistry. 1971;246(5):1192- 1200.
3. Nakayama F, Nishihara S, Iwasaki H, et al. CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV. J Biol Chem. 2001;276(19):16100-16106.
4. Gadhoum SZ, Sackstein R. CD15 expression in human myeloid cell differentiation is regulated by sialidase activity. Nat Chem Biol. 2008;4(12):751-757.
5. Ohanamalka O, Benharroch D, Isakov N, et al. Selectins and anti-CD15 (Lewis x/a) antibodies transmit activation signals in Hodgkin's lymphoma–derived cell lines. Exp Hematol. 2003;31(11):1057-1065.
6. Vestweber D, Blanks JE. Mechanisms that regulate the function of the selectins and their ligands. Physiol Rev. 1999;79(1):181-213.
7. Pinkus GS, Thomas P, Said JW. Leu-M1--a marker for Reed-Sternberg cells in Hodgkin's disease. An immunoperoxidase study of paraffin-embedded tissues. Am J Pathol. 1985;119(2):244-252.
8. Skubitz KM, Snook II RW. Monoclonal antibodies that recognize lacto-N- fucopentaose III (CD15) react with the adhesion-promoting glycoprotein family (LFA- 1/HMac-1/gp 150,95) and CR1 on human neutrophils. J Immunol. 1987;139:1631- 1639.
9. Arber DA, Weiss LM. CD15 A Review. Applied Immunohistochemistry. 1993;1(1):17-30.
10. Tao W, Wang M, Voss ED, et al. Comparative proteomic analysis of human CD34+ stem/progenitor cells and mature CD15+ myeloid cells. Stem Cells. 2004;22(6):1003-1014.
11. Orazi A, Weiss LM, Foucar K, Knowles DM. Knowles' Neoplastic Hematopathology Third Edition. 3rd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2014.
12. Fox N, Damjanov I, Knowles BB, Solter D. Immunohistochemical localization of the mouse stage-specific embryonic antigen 1 in human tissues and tumors. Cancer Res. 1983;43(2):669-678.
13. Sheibani K, Battifora H, Burke JS, Rappaport H. Leu-M1 antigen in human neoplasms. An immunohistologic study of 400 cases. Am J Surg Pathol. 1986;10(4):227-236.
14. Wick MR. Immunohistochemical approaches to the diagnosis of undifferentiated malignant tumors. Ann Diagn Pathol. 2008;12(1):72-84.
15. Porter EM, Bevins CL, Ghosh D, Ganz T. The multifaceted Paneth cell. Cell Mol Life Sci. 2002;59(1):156-170.
16. Valente AM, Taatjes DJ, Mount SL. Comparison of the pattern of expression of Leu- M1 antigen in adenocarcinomas, neutrophils and Hodgkin's disease by immunoelectron microscopy. Histochem Cell Biol.", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Product Purpose", "Value": "CONFIRM anti-CD15 (MMA) Mouse Monoclonal Primary Antibody is intended for laboratory use in the qualitative immunohistochemical detection of CD15 by light microscopy in sections of formalin-fixed, paraffin-embedded tissue stained on a BenchMark IHC/ISH instrument.

This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls.

This antibody is intended for in vitro diagnostic (IVD) use.", "Language": "en", "Country": "XG", "Code": "Product Purpose" } ] } } ] }