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"Name": "Storage Conditions (Product)",
"Value": "Upon receipt and when not in use, store at 2-8ºC. Do not freeze.",
"Language": "en",
"Country": "XG",
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One 5 mL dispenser of CONFIRM anti-CD15 (MMA) antibody contains approximately 56 μg of a mouse monoclonal antibody.
The antibody is diluted in Tris-HCI with carrier protein, and 0.10% ProClin 300, a preservative.
Specific antibody concentration is approximately 11 μg/mL. There is no known nonspecific antibody reactivity observed in this product.
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Refer to the appropriate VENTANA detection kit method sheet for detailed descriptions of: Principle of the Procedure, Material and Methods, Specimen Collection and Preparation for Analysis, Quality Control Procedures, Troubleshooting, Interpretation of Results, and Limitations.",
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"Country": "XG",
"Code": "Content"
},
{
"Name": "Intended Use",
"Value": "CONFIRM anti-CD15 (MMA) Mouse Monoclonal Primary Antibody is intended for laboratory use in the qualitative immunohistochemical detection of CD15 by light microscopy in sections of formalin-fixed, paraffin-embedded tissue stained on a BenchMark IHC/ISH instrument.
This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls.
This antibody is intended for in vitro diagnostic (IVD) use.",
"Language": "en",
"Country": "XG",
"Code": "Intended Use"
},
{
"Name": "Principle",
"Value": "CONFIRM anti-CD15 (MMA) antibody binds to the CD15 protein in formalin-fixed, paraffin-embedded tissue (FFPE) sections and exhibits a membranous staining pattern. This antibody can be visualized using OptiView DAB IHC Detection Kit (Cat. No. 760-700 / 06396500001) or ultraView Universal DAB Detection Kit (Cat. No. 760-500 / 05269806001). Refer to the respective method sheet for further information.",
"Language": "en",
"Country": "XG",
"Code": "Principle"
},
{
"Name": "Background Information",
"Value": "CONFIRM anti-CD15 (MMA) Mouse Monoclonal Primary Antibody (CONFIRM anti-CD15 (MMA) antibody) recognizes lacto-N-fucopentaose III. CD15, also known as Lewis X (Lex) and stage-specific embryonic antigen-1 (SSEA-1), is a carbohydrate antigen expressed on glycolipids and glycoproteins that was first identified in mice, human milk, and some adenocarcinomas.1,2 The antigen is formed through fucosylation, which is specifically directed by FUT4 (Fucosyltransferase 4) in promyelocytes and monocytes and FUT9 in granulocytes.3 Of note, a related epitope, sialyl-CD15, differs in structure and modifications present on the carbohydrate molecule, and antibodies that recognize one epitope do not recognize the other.4 Non-sialylated CD15 is involved in cell-cell adhesion and preferentially binds to P-selectin and E-selectin.5,6 CD15 is also implicated in the activation of neutrophils and macrophages, a function that may be specific to the moiety of CD15 or selectins present.5
Antibodies against CD15 normally react in a strong cell surface membrane staining pattern with granulocytes and granulocyte precursors, monocytes, a subset of tissue macrophages, and activated T-lymphocytes.4,7-11 The antigen is also expressed in activated B-cells and T-cells, follicular dendritic cells, Paneth cells, and neuroendocrine cells, and a wide range of epithelial tissues including, but not limited to, gastrointestinal tract, liver, pancreas, kidney, bladder, breast and salivary gland.11-15
CD15 antigen is aberrantly expressed in Hodgkin/Reed-Sternberg cells in classic Hodgkin lymphoma and, therefore, is commonly used as part of a panel to confirm a classic Hodgkin lymphoma diagnosis.7,9,13,16
The clinical application of the detection of CD15 by immunohistochemistry (IHC) with the CONFIRM anti-CD15 (MMA) antibody is as an aid in the diagnosis of classic Hodgkin lymphoma.
1. Kobata A, Ginsburg V. Oligosaccharides of Human Milk II. Isolation And Characterization Of A New Pentasaccharide, Lacto-N-Fucopentaose III. The Journal of Biological Chemistry. 1969;244(20):5496-5502.
2. Yang HJ, Hakomori SI. A Sphingolipid Having A Novel Type of Ceramide And Lacto-N-Fucopentaose. The Journal of Biological Chemistry. 1971;246(5):1192- 1200.
3. Nakayama F, Nishihara S, Iwasaki H, et al. CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV. J Biol Chem. 2001;276(19):16100-16106.
4. Gadhoum SZ, Sackstein R. CD15 expression in human myeloid cell differentiation is regulated by sialidase activity. Nat Chem Biol. 2008;4(12):751-757.
5. Ohanamalka O, Benharroch D, Isakov N, et al. Selectins and anti-CD15 (Lewis x/a) antibodies transmit activation signals in Hodgkin's lymphoma–derived cell lines. Exp Hematol. 2003;31(11):1057-1065.
6. Vestweber D, Blanks JE. Mechanisms that regulate the function of the selectins and their ligands. Physiol Rev. 1999;79(1):181-213.
7. Pinkus GS, Thomas P, Said JW. Leu-M1--a marker for Reed-Sternberg cells in Hodgkin's disease. An immunoperoxidase study of paraffin-embedded tissues. Am J Pathol. 1985;119(2):244-252.
8. Skubitz KM, Snook II RW. Monoclonal antibodies that recognize lacto-N- fucopentaose III (CD15) react with the adhesion-promoting glycoprotein family (LFA- 1/HMac-1/gp 150,95) and CR1 on human neutrophils. J Immunol. 1987;139:1631- 1639.
9. Arber DA, Weiss LM. CD15 A Review. Applied Immunohistochemistry. 1993;1(1):17-30.
10. Tao W, Wang M, Voss ED, et al. Comparative proteomic analysis of human CD34+ stem/progenitor cells and mature CD15+ myeloid cells. Stem Cells. 2004;22(6):1003-1014.
11. Orazi A, Weiss LM, Foucar K, Knowles DM. Knowles' Neoplastic Hematopathology Third Edition. 3rd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2014.
12. Fox N, Damjanov I, Knowles BB, Solter D. Immunohistochemical localization of the mouse stage-specific embryonic antigen 1 in human tissues and tumors. Cancer Res. 1983;43(2):669-678.
13. Sheibani K, Battifora H, Burke JS, Rappaport H. Leu-M1 antigen in human neoplasms. An immunohistologic study of 400 cases. Am J Surg Pathol. 1986;10(4):227-236.
14. Wick MR. Immunohistochemical approaches to the diagnosis of undifferentiated malignant tumors. Ann Diagn Pathol. 2008;12(1):72-84.
15. Porter EM, Bevins CL, Ghosh D, Ganz T. The multifaceted Paneth cell. Cell Mol Life Sci. 2002;59(1):156-170.
16. Valente AM, Taatjes DJ, Mount SL. Comparison of the pattern of expression of Leu- M1 antigen in adenocarcinomas, neutrophils and Hodgkin's disease by immunoelectron microscopy. Histochem Cell Biol.",
"Language": "en",
"Country": "XG",
"Code": "Background Information"
},
{
"Name": "Product Purpose",
"Value": "CONFIRM anti-CD15 (MMA) Mouse Monoclonal Primary Antibody is intended for laboratory use in the qualitative immunohistochemical detection of CD15 by light microscopy in sections of formalin-fixed, paraffin-embedded tissue stained on a BenchMark IHC/ISH instrument.
This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls.
This antibody is intended for in vitro diagnostic (IVD) use.",
"Language": "en",
"Country": "XG",
"Code": "Product Purpose"
}
]
}
}
]
}