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Specific antibody concentration is approximately 0.4 μg/mL. There is no known non- specific antibody reactivity observed in this product.
CONFIRM anti-CD3 (2GV6) antibody is a recombinant rabbit monoclonal antibody produced as purified cell culture supernatant.
Refer to the appropriate VENTANA detection kit method sheet for detailed descriptions of: Principle of the Procedure, Material and Methods, Specimen Collection and Preparation for Analysis, Quality Control Procedures, Troubleshooting, Interpretation of Results, and Limitations.",
"Language": "en",
"Country": "XG",
"Code": "Content"
},
{
"Name": "Background Information",
"Value": "CD3 is a multimeric protein complex composed of four distinct polypeptide chains: gamma, delta, epsilon, and zeta.1,2 Like many commercial CD3 antibodies, CONFIRM anti-CD3 (2GV6) Rabbit Monoclonal Primary Antibody (CONFIRM anti-CD3 (2GV6) antibody) detects the epsilon chain of CD3 which is expressed on T-cells and natural killer (NK)-cells.1,3 Structurally, CD3 proteins have an N-terminal domain that recognizes foreign antigens, a transmembrane domain,and a cytoplasmic domain, which contains immunoreceptor tyrosine-based activation motifs that propagate signaling cascades.2,4 Through its cytoplasmic domain, CD3 associates with the T-cell receptor (TCR) and initiates downstream signaling cascades upon antigen recognition.1,4
On normal tissues, CD3 is expressed on T-cells, Purkinje neurons, and the CD3-epsilon chain is expressed on NK-cells.1,2 On T-cells, CD3 is initially expressed in the cytoplasm of early thymocytes and is later expressed on the cell membrane of mature T-cells.1,2 The appearance of CD3 throughout many stages of T-cell maturation makes it an ideal pan T- cell marker and its expression is typically maintained in many T-cell neoplasms.1,2
However, CD3 expression may occasionally be lost in some T-cell lymphoma subtypes, particularly anaplastic large cell lymphoma (ALCL).3 CD3 is typically not expressed on B- cells, myeloid cells, or their malignant counterparts.1,2,3
Detection of CD3 by immunohistochemistry (IHC) with the CONFIRM anti-CD3 (2GV6) antibody may be used to aid in the identification of normal and neoplastic T-cells. It may be used as part of a panel of IHC studies. The staining pattern is membranous and/or cytoplasmic.
1. Dabbs DJ. Diagnostic Immunohistochemistry Theranostic and Genomic Applications, 5th Edition. Vol 5. Amsterdam, Netherlands: Elsevier; 2019.
2. Naeim F. Principles of Immunophenotyping. In: Naeim F, Rao PN, Grody WW, eds. Hematopathology: Morphology, Immunophenotype, Cytogenetics, and Molecular Approaches. Cambridge, MA: Academic Press; 2009.
3. Higgins RA, Blankenship JE, Kinney MC. Application of Immunohistochemistry in the Diagnosis of Non-Hodgkin and Hodgkin Lymphoma. Arch Pathol Lab Med. 2008;132(3):441-4",
"Language": "en",
"Country": "XG",
"Code": "Background Information"
},
{
"Name": "Principle",
"Value": "CONFIRM anti-CD3 (2GV6) antibody binds to the CD3 protein in formalin-fixed, paraffin- embedded (FFPE) tissue sections. CONFIRM anti-CD3 (2GV6) antibody can be visualized using OptiView DAB IHC Detection Kit (Cat. No. 760-700 / 06396500001) or ultra View Universal DAB Detection Kit (Cat. No. 760-500 / 05269806001). Refer to the respective method sheet for further information.",
"Language": "en",
"Country": "XG",
"Code": "Principle"
},
{
"Name": "Product Purpose",
"Value": "CONFIRM anti-CD3 (2GV6) Rabbit Monoclonal Primary Antibody is intended for laboratory use in the qualitative immunohistochemical detection of CD3 by light microscopy in sections of formalin-fixed, paraffin- embedded tissue stained on a BenchMark IHC/ISH instruments
This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls.
This antibody is intended for in vitro diagnostic (IVD) use.
",
"Language": "en",
"Country": "XG",
"Code": "Product Purpose"
}
]
}
}
]
}
