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One 5 mL dispenser of Anti-CD43 (L60) antibody contains approximately 5 μg of a mouse monoclonal antibody.
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Refer to the appropriate VENTANA detection kit method sheet for detailed descriptions of: Principle of the Procedure, Material and Methods, Specimen Collection and Preparation for Analysis, Quality Control Procedures, Troubleshooting, Interpretation of Results, and Limitations.",
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"Name": "Intended Use",
"Value": "Anti-CD43 (L60) Mouse Monoclonal Primary Antibody is intended for laboratory use in the qualitative immunohistochemical detection of CD43 by light microscopy in sections of formalin-fixed, paraffin-embedded tissue stained on a BenchMark IHC/ISH instrument.
This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls.
This antibody is intended for in vitro diagnostic (IVD) use.",
"Language": "en",
"Country": "XG",
"Code": "Intended Use"
},
{
"Name": "Principle",
"Value": "Anti-CD43 (L60) antibody binds to the CD43 protein in formalin-fixed, paraffin-embedded (FFPE) tissue sections. This antibody can be visualized using OptiView DAB IHC Detection Kit (Cat. No. 760-700 / 06396500001), and ultraView Universal DAB Detection Kit (Cat. No. 760-500 / 05269806001). Refer to the respective method sheets for further information.",
"Language": "en",
"Country": "XG",
"Code": "Principle"
},
{
"Name": "Background Information",
"Value": "CD43, also known as leucosialin or sialophorin, is a transmembrane glycoprotein antigen expressed on the plasma membrane and in the cytoplasm of hematopoietic precursors, cells of myeloid origin except mature erythrocytes, and normal lymphoid cells including T cells, NK cells, precursor B cells, B cells in the gastrointestinal mucosa and plasma cells, but not resting peripheral B cells.1,2 Western blotting demonstrates heterogeneity of the antigen staining bands in the 110-160 kD range. CD43 is expressed by most T cell lymphomas and some B cell lymphomas.1-4 Anti-CD43 (L60) Mouse Monoclonal Primary Antibody (Anti-CD43 (L60) antibody) binds specifically to antigens located in the plasma membrane and cytoplasmic regions of normal granulocytes, monocytes, histiocytes, T cells, and some B cells.
CD43 is expressed by most T cell lymphomas.1-4 When used in a panel with other T- cell markers, the detection of CD43 by immunohistochemistry (IHC) with the Anti-CD43 (L60) antibody may be used as an aid to diagnose T-cell lymphoma.
While normal mature B cells do not express CD43, some mature B-cell neoplasms (e.g. small lymphocytic lymphoma and mantle cell lymphoma) often express it aberrantly.1-4 Thus, detection of CD43 by IHC with the Anti-CD43 (L60) antibody may also be used as an aid to characterize B-cell lymphoma. CD43 IHC is mostly used to characterize small B-cell lymphomas. CD43 positivity is highest among chronic lymphocytic leukemia/small lymphocytic lymphoma and mantle cell lymphoma, and is almost always absent in follicular lymphoma.1,2 Its use to characterize other B-cell lymphoma subtypes is more limited.1,2
The staining pattern of this antibody is membranous and cytoplasmic. It may be used as part of a panel of IHC studies.
1. Orazi A, Foucar K, Knowles D, et al. Knowles Neoplastic Hematopathology. Lippincott Williams & Wilkins; 2013.
2. Dabbs DJ. Diagnostic Immunohistochemistry: Theranostic and Genomic Applications. Elsevier; 2018.
3. Strickler JG, Weiss LM, Copenhaver CM, Bindl J, McDaid R, Buck D, Warnke R. Monoclonal antibodies reactive in routinely processed tissue sections of malignant lymphoma, with emphasis on T cell lymphomas. Hum Pathol. Aug; 18(8):808-14, 1987.
4. Stross WP, Warnke RA, Flavell DJ, Flavell SU, Simmons D, Gatter KC, Mason DY. Molecule detected in formalin fixed tissue by antibodies MT1, DF-T1, and L60 (Leu- 22) corresponds to CD43 antigen. J Clin Pathol Sep;42(9):953-61, 1989.",
"Language": "en",
"Country": "XG",
"Code": "Background Information"
},
{
"Name": "Product Purpose",
"Value": "Anti-CD43 (L60) Mouse Monoclonal Primary Antibody is intended for laboratory use in the qualitative immunohistochemical detection of CD43 by light microscopy in sections of formalin-fixed, paraffin-embedded tissue stained on a BenchMark IHC/ISH instrument.
This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls.
This antibody is intended for in vitro diagnostic (IVD) use.",
"Language": "en",
"Country": "XG",
"Code": "Product Purpose"
}
]
}
}
]
}
