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{
"Name": "Background Information",
"Value": "CD45,also known as leukocyte common antigen (LCA) is a protein tyrosine phosphatase expressed on the surface of all nucleated hematopoietic cells and their precursors, except on mature erythrocytes.1,2 CD45 is a family of five to eight glycoproteins (MW 180 to 220 kD) encodedon chromosome 1q32.3 Various isoforms are generated by alternative splicing of three exons that can beinserted after an NH2-terminal sequence of eight amino acids found on all isoforms.4 The various isoforms are expressed differently on different lymphoid cells and are distinguished by epitopes termed CD45RA, CD45RB, CD45RC and CD45RO.5 CONFIRM anti-CD45, LCA (RP2/18) Primary Antibody contains a mouse monoclonal antibody directed against the CD45RB epitope found on the membrane of leukocytic cells.5,6 CONFIRM anti -CD45, LCA (RP2/18) Primary Antibody has been shown to react with the 220-, 205-, and 190 kD isoforms of CD45.5,6
The detection of CD45 by immunohistochemistry (IHC) with the CONFIRM anti-CD45, LCA (RP2/18) Primary Antibody may be used to detect hematolymphoid cells to aid in the diagnosis of lymphoma.
The staining pattern of this antibody isusuallymembranous, although cytoplasmic staining may be observed at times. It may be used as part of a panel of IHC studies.
1.Orazi A, Foucar K, Knowles D, et al. Knowles Neoplastic Hematopathology. Lippincott Williams & Wilkins; 2013. 2. Dabbs DJ. Diagnostic Immunohistochemistry: Theranostic and Genomic Applications. Elsevier; 2018.
3. Taylor RT, Cote RJ. Immunomicroscopy: A Diagnostic Tool for the Surgical Pathologist, 2nd Edition. W.B. Saunders Company, Philadelphia, 1994.
4. Barclay NA, Birkeland ML, Brown MH, Beyers AD, Davis SJ, Somoza C, Williams, AF. The Leucocyte Antigen Facts Book. Academic Press, London, 1993
5. Pulido R, Cebrian M, Acevedo A, de Landazuri MO, Sanchez-Madrid F. Comparative biochemical and tissue distribution study of four distinct CD45 antigen specificities. J Immunol, 140(11): 3851-3857, 1988.
6. Zapata JM, Pulido R, Acevedo A, Sanchez-Madrid F, de Landazuri MO.Human CD45RC Specificity. A novel marker for T cells at different maturation and activation stages. J.Immunol, 152(8): 3852-3861,",
"Language": "en",
"Country": "XG",
"Code": "Background Information"
},
{
"Name": "Intended Use",
"Value": "CONFIRM anti-CD45, LCA (RP2/18) Primary Antibody is intended for laboratory use in the qualitative immunohistochemical detection of CD45 by light microscopy in sections of formalin-fixed, paraffin-embedded tissuestainedon a BenchMark IHC/ISH instrument.
This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls.
This antibody is intended for in vitro diagnostic (IVD) use.",
"Language": "en",
"Country": "XG",
"Code": "Intended Use"
},
{
"Name": "Content",
"Value": "CONFIRM anti-CD45, LCA (RP2/18) Primary Antibody contains sufficient reagent for 50 tests.
One 5 mL dispenser of CONFIRM anti-CD45, LCA (RP2/18) Primary Antibody contains approximately 5μg of a mouse monoclonal antibody.
The antibody is diluted in a buffer containing carrier protein and preservative.
Specific antibody concentration is approximately 1 μg/mL. There is no known non-specific antibody reactivity observed in this product.
Refer to the appropriate VENTANA detection kit method sheet for detailed descriptions of: Principle of the Procedure, Material and Methods, Specimen Collection and Preparation for Analysis, Quality Control Procedures, Troubleshooting, Interpretation of Results, and Limitations.",
"Language": "en",
"Country": "XG",
"Code": "Content"
},
{
"Name": "Principle",
"Value": "CONFIRM anti-CD45, LCA (RP2/18) PrimaryAntibodymay be used as the primary antibody for immunohistochemical staining of formalin-fixed, paraffin-embedded (FFPE) tissue sections. In general, immunohistochemical staining allows the visualization of antigens via the sequential application of aspecific antibody (primary antibody) that binds to the antigen, a secondary antibody (link antibody) that binds to the primary antibody, an enzyme complex and a chromogenic substrate with interposed washing steps. The enzymatic activation of the chromogen results in a visible reaction product at the antigen site. The specimen may then be counterstained and cover slipped. Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with a particular antigen.
CONFIRM anti-CD45, LCA (RP2/18) PrimaryAntibody can be visualized using OptiView DAB IHC Detection Kit (Cat. No. 760-700 / 06396500001), and ultra View UniversalDAB Detection Kit (Cat. No. 760-500/ 05269806001). Refer to therespectivemethod sheet for further information.",
"Language": "en",
"Country": "XG",
"Code": "Principle"
},
{
"Name": "Product Purpose",
"Value": "CONFIRM anti-CD45, LCA (RP2/18) Primary Antibody is intended for laboratory use in the qualitative immunohistochemical detection of CD45 by light microscopy in sections of formalin-fixed, paraffin-embedded tissuestainedon a BenchMark IHC/ISH instrument.
This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls.
This antibody is intended for in vitro diagnostic (IVD) use.",
"Language": "en",
"Country": "XG",
"Code": "Product Purpose"
}
]
}
}
]
}
