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One 5 mL dispenser of CONFIRM anti-CD68 (KP-1) antibody contains approximately 2 μg of a mouse monoclonal antibody
The antibody is diluted in phosphate buffered saline, with a carrier protein and a preservative.
Specific antibody concentration is approximately 0.4 μg/mL. There is no known non-specific antibody reactivity observed in this product.
CONFIRM anti-CD68 (KP-1) antibody is a mouse monoclonal antibody produced as cell culture supernatant.
Refer to the appropriate VENTANA detection kit method sheet for detailed descriptions of: Principle of the Procedure, Material and Methods, Specimen Collection and Preparation for Analysis, Quality Control Procedures, Troubleshooting, Interpretation of Results, and Limitations.",
"Language": "en",
"Country": "XG",
"Code": "Content"
},
{
"Name": "Background Information",
"Value": "Cluster of differentiation 68 (CD68) is a member of a broad family of proteins known as lysosomal/endosomal-associated membrane glycoproteins (LAMPs).1,2 The antigen is a 110 kD integral membrane glycoprotein with one LAMP domain, a transmembrane domain, and a short cytoplasmic tail that holds motifs important for localizing to lysosomes.1,2 CD68 molecule is also known as scavenger receptor class D member 1, CD68 antigen, and macrophage antigen CD68.1,2 The function of CD68 is unknown, however evidence suggests that it inhibits antigen uptake, loading, or trafficking of major histocompatibility complex class II (MHC-II).1-4
Although predominantly expressed in endosomal and lysosomal compartments of the cell, a smaller fraction of CD68 is located on the cell surface.1,5,6,7 CD68 is highly expressed by monocytes and tissue macrophages, such as histiocytes, osteoclasts, and Kupffer cells, and is expressed to a lesser extent in other cells of the myeloid lineage, such as dendritic cells.1 Though initially identified in macrophages, CD68 expression has since been tied to the lysosomal and endosomal content of cells.8 Because of this, CD68 expression is not restricted to the myeloid lineage, and expression is seen in other hematopoietic and non-hematopoietic cell types, such as fibroblasts and some T lymphocytes.7,9,10 Clinically, the high lysosomal content of macrophages and monocytes makes CD68 a useful marker to identify areas of inflammation and immune infiltration of tumors.1,6,11,12
The clinical application for the detection of CD68 by immunohistochemistry with the CONFIRM anti-CD68 (KP-1) Primary Antibody (CONFIRM anti-CD68 (KP-1) antibody) is as an aid in the identification of macrophages in normal or neoplastic tissue.
1. Chistiakov DA, Killingsworth MC, Myasoedova VA, Orekhov AN, Bobryshev YV. CD68/macrosialin: not just a histochemical marker. Lab Invest. 2017;97(1):4-13.
2. Alessandrini F, Pezze L, Ciribilli Y. LAMPs: Shedding light on cancer biology. Semin Oncol. 2017;44(4):239-253.
3. Barois N, de Saint-Vis B, Lebecque S, Geuze HJ, Kleijmeer MJ. MHC class II compartments in human dendritic cells undergo profound structural changes upon activation. Traffic. 2002;3(12):894-905.
4. Song L, Lee C, Schindler C. Deletion of the murine scavenger receptor CD68. J Lipid Res. 2011;52(8):1542-1550.
5. Favara BE, Feller AC, Pauli M, et al. Contemporary classification of histiocytic disorders. The WHO Committee On Histiocytic/Reticulum Cell Proliferations. Reclassification Working Group of the Histiocyte Society. Med Pediatr Oncol. 1997;29(3):157-166.
6. Ferenbach D, Hughes J. Macrophages and dendritic cells: what is the difference? Kidney Int. 2008;74(1):5-7.
7. Dabbs DJ. Diagnostic Immunohistochemistry: Theranostic and Genomic Applications, 5th Edition. 5th ed. Philadelphia, PA: Elsevier; 2019.
8. Tsang WYW, Chan JKC. Kp1 (Cd68) Staining of Granular-Cell Neoplasms - Is Kp1 a Marker for Lysosomes Rather Than the Histiocytic Lineage. Histopathology. 1992;21(1):84-86.
9. Gottfried E, Kunz-Schughart LA, Weber A, et al. Expression of CD68 in non-myeloid cell types. Scand J Immunol. 2008;67(5):453-463.
10. Hameed A, Hruban RH, Gage W, Pettis G, Fox WM, 3rd. Immunohistochemical expression of CD68 antigen in human peripheral blood T cells. Hum Pathol. 1994;25(9):872-876.
11. Emile JF, Abla O, Fraitag S, et al. Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages. Blood. 2016;127(22):2672- 2681.
12. Rich RR, Fleisher TA, Shearer WT, Schroeder HW, Frew AJ, Weyand CM. Clinical Immunology: Principles and Practice. 5th edition ed: Elsevier",
"Language": "en",
"Country": "XG",
"Code": "Background Information"
},
{
"Name": "Principle",
"Value": "CONFIRM anti-CD68 (KP-1) antibody is a mouse monoclonal antibody which binds to CD68 in formalin-fixed, paraffin-embedded (FFPE) tissue sections. This antibody can be visualized using the OptiView DAB IHC Detection Kit (Cat. No. 760-700 / 06396500001) or ultraView Universal DAB Detection Kit (Cat. No. 760-500 / 05269806001). Refer to the respective method sheets for further information.",
"Language": "en",
"Country": "XG",
"Code": "Principle"
},
{
"Name": "Product Purpose",
"Value": "CONFIRM anti-CD68 (KP-1) Primary Antibody is intended for laboratory use in the qualitative immunohistochemical detection of CD68 by light microscopy in sections of formalin-fixed, paraffin- embedded tissue stained on a BenchMark IHC/ISH instrument.
This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls.
This antibody is intended for in vitro diagnostic use.",
"Language": "en",
"Country": "XG",
"Code": "Product Purpose"
}
]
}
}
]
}
