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"Active" }, { "IdentifierofStructureSystem": "OWP_Techniques", "NameofStructureSystem": "Techniques", "StructureNodeID": "073-00", "StructureGroupPath": "Immunohistochemistry (IHC)", "StructureGroupName": "Immunohistochemistry (IHC)", "StructureNodeStatus": "Active" }, { "IdentifierofStructureSystem": "Applications", "NameofStructureSystem": "Applications", "StructureNodeID": "99-00-00", "StructureGroupPath": "", "StructureGroupName": "", "StructureNodeStatus": "Inactive" }, { "IdentifierofStructureSystem": "Pathogens", "NameofStructureSystem": "Pathogens", "StructureNodeID": "99-00-00", "StructureGroupPath": "", "StructureGroupName": "", "StructureNodeStatus": "Inactive" }, { "IdentifierofStructureSystem": "Disease_Areas", "NameofStructureSystem": "Disease Areas", "StructureNodeID": "99-00-00", "StructureGroupPath": "", "StructureGroupName": "", "StructureNodeStatus": "Inactive" }, { "IdentifierofStructureSystem": "Health_Topics", "NameofStructureSystem": "Health Topics", "StructureNodeID": "99-00-00", "StructureGroupPath": "", "StructureGroupName": "", "StructureNodeStatus": "Inactive" } ] } ] }, "ProductSpec": [ { "ProductSpecVariant": { "Chapters": [ { "Name": "Storage Conditions (Product)", "Value": "Upon receipt and when not in use, store at 2-8°C. Do not freeze.", "Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Content", "Value": "Anti-Cytokeratin 17 (SP95) antibody contains sufficient reagent for 50 tests.

One 5 mL dispenser of anti-Cytokeratin 17 (SP95) antibody contains approximately 5.5 μg of a rabbit monoclonal antibody.

The antibody is diluted in a Tris HCl dilution buffer with Brij-35 and 0.10% ProClin 300, a preservative.

Specific antibody concentration is approximately 1.1 μg/mL. There is no known non-specific antibody reactivity observed in this product.

Anti-Cytokeratin 17 (SP95) antibody is a recombinant rabbit monoclonal antibody produced as purified cell culture supernatant.

Refer to the appropriate VENTANA detection kit method sheet for detailed descriptions of: Principle of the Procedure, Material and Methods, Specimen Collection and Preparation for Analysis, Quality Control Procedures, Troubleshooting, Interpretation of Results, and Limitations.", "Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Intended Use", "Value": "Anti-Cytokeratin 17 (SP95) Rabbit Monoclonal Primary Antibody is intended for laboratory use in the qualitative immunohistochemical detection of cytokeratin 17 (CK17) by light microscopy in sections of formalin- fixed, paraffin-embedded tissue stained on a BenchMark IHC/ISH instrument.

This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls.

This antibody is intended for in vitro diagnostic (IVD) use.", "Language": "en", "Country": "XG", "Code": "Intended Use" }, { "Name": "Background Information", "Value": "Anti-Cytokeratin 17 (SP95) Rabbit Monoclonal Primary Antibody (anti-Cytokeratin 17 (SP95) antibody) is a rabbit monoclonal antibody produced against the CK17 protein. CK17 is a type I (acidic) cytokeratin encoded by the KRT17 gene and is expressed in myoepithelial cells and in the basal cells of complex epithelia.^1-5CK17 expression is typically present in squamous cell carcinomas of the lung, cervix, and oral cavity.^1,2,3 Of note, some undifferentiated or poorly differentiated squamous cell carcinomas may display lower levels of CK17 expression.^2,3

The detection of CK17 by immunohistochemistry (IHC) with the anti-Cytokeratin 17 (SP95) antibody may be used to aid in the identification of squamous cell carcinomas. This antibody may be used as part of a panel of IHC studies. The staining pattern is membranous and/or cytoplasmic.

1. Dabbs DJ. Diagnostic Immunohistochemistry: Theranostic and Genomic Applications, 5th Edition. Amsterdam, Netherlands: Elsevier; 2018.
2. Chu PG, Weiss LM. Keratin Expression in Human Tissues and Neoplasms. Histopathology. 2002;40(5):403-439.
3. Moll R, Divo M, Langbein L. The Human Keratins: Biology and Pathology. Histochem Cell Biol. 2008;129(6):705-733.
4. Kumar A, Jagannathan N. Cytokeratin: A Review on Current Concepts. International Journal of Orofacial Biology. 2018;2(1).
5. Karantza V. Keratins in Health and Cancer: More Than Mere Epithelial Cell Markers. Oncogene. 2011;30(2):127-138.", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Principle", "Value": "Anti-Cytokeratin 17 (SP95) antibody binds to the CK17 protein in formalin- fixed, paraffin- embedded (FFPE) tissue sections. This antibody can be visualized using ultraView Universal DAB Detection Kit (Cat. No. 760-500 / 05269806001). Refer to the respective method sheet for further information.", "Language": "en", "Country": "XG", "Code": "Principle" }, { "Name": "Product Purpose", "Value": "Anti-Cytokeratin 17 (SP95) Rabbit Monoclonal Primary Antibody is intended for laboratory use in the qualitative immunohistochemical detection of cytokeratin 17 (CK17) by light microscopy in sections of formalin- fixed, paraffin-embedded tissue stained on a BenchMark IHC/ISH instrument.

This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls.

This antibody is intended for in vitro diagnostic (IVD) use.", "Language": "en", "Country": "XG", "Code": "Product Purpose" } ] } } ] }

anti-Cytokeratin 17 (SP95) Rabbit Monoclonal Primary Antibody

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