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"StructureNodeStatus": "Inactive" }, { "IdentifierofStructureSystem": "Pathogens", "NameofStructureSystem": "Pathogens", "StructureNodeID": "99-00-00", "StructureGroupPath": "", "StructureGroupName": "", "StructureNodeStatus": "Inactive" }, { "IdentifierofStructureSystem": "Disease_Areas", "NameofStructureSystem": "Disease Areas", "StructureNodeID": "99-00-00", "StructureGroupPath": "", "StructureGroupName": "", "StructureNodeStatus": "Inactive" }, { "IdentifierofStructureSystem": "Health_Topics", "NameofStructureSystem": "Health Topics", "StructureNodeID": "99-00-00", "StructureGroupPath": "", "StructureGroupName": "", "StructureNodeStatus": "Inactive" } ] } ] }, "ProductSpec": [ { "ProductSpecVariant": { "Chapters": [ { "Name": "Storage Conditions (Product)", "Value": "Upon receipt and when not in use, store at 2–8°C. Do not freeze.", "Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Content", "Value": "CONFIRM anti-Cytokeratin 7 (SP52) antibody contains sufficient reagent for 50 tests.

One 5 mL dispenser of CONFIRM anti-Cytokeratin 7 (SP52) antibody contains approximately 2.5 μg of a rabbit monoclonal antibody.
The antibody is diluted in Tris HCl with carrier protein and 0.10% ProClin 300, a preservative. Specific antibody concentration is approximately 0.5 μg/mL. There is no known nonspecific antibody reactivity observed in this product.
CONFIRM anti-Cytokeratin 7 (SP52) antibody is a recombinant rabbit monoclonal antibody produced as purified cell culture supernatant.
Refer to the appropriate VENTANA detection kit method sheet for detailed descriptions of: Principle of the Procedure, Material and Methods, Specimen Collection and Preparation for Analysis, Quality Control Procedures, Troubleshooting, Interpretation of Results, and Limitations.", "Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Intended Use", "Value": "CONFIRM anti-Cytokeratin 7 (SP52) Rabbit Monoclonal Primary Antibody is intended for laboratory use in the qualitative immunohistochemical detection of cytokeratin 7 (CK7) by light microscopy in sections of formalin-fixed, paraffin-embedded tissue stained on a BenchMark IHC/ISH instrument.

This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information and proper controls.

This antibody is intended for in vitro diagnostic (IVD) use.", "Language": "en", "Country": "XG", "Code": "Intended Use" }, { "Name": "Background Information", "Value": "CONFIRM anti-Cytokeratin 7 (SP52) Rabbit Monoclonal Primary Antibody (CONFIRM anti-Cytokeratin 7 (SP52) antibody) detects CK7, a type II (basic/neutral) keratin encoded by the KRT7 gene.1,2 Expression of CK7 is typically found in many epithelia in organs such as the lung, breast, uterus, ovary, pancreas, thyroid, and bladder.1,2,3,4,5 It is typically present in lung adenocarcinoma and carcinomas of the breast, uterus, and ovary.1,2,3,4 Of note, the diagnostic utility of CK7 increases when used in conjunction with cytokeratin 20 (CK20).1,2,3,4,6
The detection of CK7 by immunohistochemistry (IHC) with the CONFIRM anti-Cytokeratin 7 (SP52) antibody may be used to aid in the identification of normal and neoplastic epithelial cells of the lung, breast, and female gynecologic tract (uterus, ovary, fallopian tube). The staining pattern is cytoplasmic.

1. Dabbs DJ. Diagnostic Immunohistochemistry: Theranostic and Genomic Applications, 5th Edition. Amsterdam, Netherlands: Elsevier; 2018.
2. Chu PG, Weiss LM. Keratin Expression in Human Tissues and Neoplasms. Histopathology. 2002;40(5):403-439.
3. Karantza V. Keratins in Health and Cancer: More Than Mere Epithelial Cell Markers. Oncogene. 2011;30(2):127-138.
4. Moll R, Divo M, Langbein L. The Human Keratins: Biology and Pathology. Histochem Cell Biol. 2008;129(6):705-733.
5. Kumar A, Jagannathan N. Cytokeratin: A Review on Current Concepts. International Journal of Orofacial Biology. 2018;2(1).
6. Bahrami A et al. Undifferentiated tumor: true identity by immunohistochemistry. Arch. Pathol. Lab Med. 2008;132(3):326-48.", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Principle", "Value": "CONFIRM anti-Cytokeratin 7 (SP52) antibody was raised against the carboxyl terminal region of the CK7 human protein spanning amino acids 451-469. CONFIRM anti- Cytokeratin 7 (SP52) antibody binds to CK7 protein in formalin-fixed, paraffin-embedded (FFPE) tissue sections and exhibits a cytoplasmic staining pattern. This antibody can be visualized using ultraView Universal DAB Detection Kit (Cat. No. 760-500 / 05269806001). Refer to the ultraView Universal DAB Detection Kit method sheet for further information.", "Language": "en", "Country": "XG", "Code": "Principle" }, { "Name": "Product Purpose", "Value": "CONFIRM anti-Cytokeratin 7 (SP52) Rabbit Monoclonal Primary Antibody is intended for laboratory use in the qualitative immunohistochemical detection of cytokeratin 7 (CK7) by light microscopy in sections of formalin-fixed, paraffin-embedded tissue stained on a BenchMark IHC/ISH instrument.

This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information and proper controls.

This antibody is intended for in vitro diagnostic (IVD) use.", "Language": "en", "Country": "XG", "Code": "Product Purpose" } ] } } ] }

CONFIRM anti-Cytokeratin 7 (SP52) Rabbit Monoclonal Primary Antibody

IVD For in vitro diagnostic use.
CONFIRM anti-Cytokeratin 7 (SP52) Rabbit Monoclonal Primary Antibody

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