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"Health Topics", "StructureNodeID": "99-00-00", "StructureGroupPath": "", "StructureGroupName": "", "StructureNodeStatus": "Inactive" } ] } ] }, "ProductSpec": [ { "ProductSpecVariant": { "Chapters": [ { "Name": "Storage Conditions (Product)", "Value": "Store at 2-8° C. Do not freeze.", "Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Content", "Value": "CONFIRM anti-Desmin (DE-R-11) antibody contains sufficient reagent for 50 tests.

One 5 mL dispenser of CONFIRM anti-Desmin (DE-R-11) antibody contains approximately 25 µg of a mouse monoclonal antibody directed against desmin present in tissue.

The antibody is diluted in a buffer containing carrier protein and 0.10% ProClin 300, a preservative.

Specific antibody concentration is approximately 5 µg/mL. There is no known non-specific antibody reactivity observed in this product.

CONFIRM anti-Desmin (DE-R-11) antibody is a mouse monoclonal antibody produced as cell culture supernatant.

Refer to the appropriate VENTANA detection kit method sheet for detailed descriptions of: Principle of the Procedure, Material and Methods, Specimen Collection and Preparation for Analysis, Quality Control Procedures, Troubleshooting, Interpretation of Results, and Limitations.", "Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Intended Use", "Value": "CONFIRM anti-Desmin (DE-R-11) is intended for laboratory use in the qualitative immunohistochemical detection of desmin by light microscopy in sections of formalin-fixed, paraffinembedded tissue stained on a BenchMark IHC/ISH instrument.

This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls. This antibody is intended for in vitro diagnostic (IVD) use.", "Language": "en", "Country": "XG", "Code": "Intended Use" }, { "Name": "Background Information", "Value": "Desmin, a 53 kDa type III intermediate filament protein encoded by the DES gene, is located on chromosome 2 (2q35) and is primarily expressed in muscle cells.^1,2,3 Desmin is among the earliest structural components of muscle to appear during myogenesis and is expressed at low levels in the myotome of the somites, modulating myogenic differentiation during embryogenesis.^2,3,4 Under normal physiologic conditions, differentiated muscle cells express desmin in the z-disks of skeletal muscle and the cytoplasmic dense bodies of smooth muscle.^2,3,4

Neoplasms of myogenic lineage (i.e., smooth or skeletal muscle), including leiomyoma, leiomyosarcoma, and rhabdomyosarcoma, are among soft tissue neoplasms that generally express desmin.^1,5-8 In addition, some dedifferentiated liposarcomas, carcinomas, tumors with myofibroblastic features, and neoplasms with uncertain differentiation may variably express desmin due to entrapped reactive muscle cells.^1,5,6,8 Immunohistochemistry (IHC) is used to assess desmin expression in soft tissue neoplasms and to provide additional information regarding a tumor’s lineage or origin.^1,5-8

The detection of desmin by immunohistochemistry with the CONFIRM anti-Desmin (DE-R-11) Primary Antibody (CONFIRM anti-Desmin (DE-R-11) antibody) may be used to aid in the identification of neoplasms of myogenic origin. This antibody may be used as part of a panel of IHC studies. The cellular staining pattern for CONFIRM anti-Desmin (DE-R-11) antibody is cytoplasmic.

References

1. Dabbs DJ. Diagnostic Immunohistochemistry Theranostic and Genomic Applications, 5th Edition. Vol 5. Amsterdam, Netherlands: Elsevier; 2019.
2. Paulin D, Li Z. Desmin: A Major Intermediate Filament Protein Essential for the Structural Integrity and Function of Muscle. Exp Cell Res. 2004;301(1):1-7.
3. Hol EM, Capetanaki Y. Type III Intermediate Filaments Desmin, Glial Fibrillary Acidic Protein (GFAP), Vimentin, and Peripherin. Cold Spring Harb Perspect Biol. 2017;9(12):a021642.
4. Hnia K, Ramspacher C, Vermot J, et al. Desmin in Muscle and Associated Diseases: Beyond the Structural Function. Cell Tissue Res. 2015;360(3):591-608.
5. Antonescu CR, WHO, Classification of Tumours Editorial B. Soft Tissue and Bone Tumours. Lyon: International Agency for Research on Cancer; 2020.
6. Wei S, Henderson-Jackson E, Qian X, et al. Soft Tissue Tumor Immunohistochemistry Update: Illustrative Examples of Diagnostic Pearls to Avoid Pitfalls. Arch Pathol Lab Med. 2017;141(8):1072-1091.
7. Parham DM. Immunohistochemical Markers of Soft Tissue Tumors: Pathologic Diagnosis, Genetic Contributions, and Therapeutic Options. Anal Chem Insights. 2015;10:ACI. S32730.
8. Miettinen M. Immunohistochemistry of Soft Tissue Tumours–Review with Emphasis on 10 Markers. Histopathology. 2014;64(1):101-118.
9. Carson FL, Cappellano C.  HIstotechnology; A Self-Instructional Text, 5th edition.  American Society for Clinical Pathology Press; 2020, 2022.
10. Occupational Safety and Health Standards: Occupational exposure to hazardous chemicals in laboratories. (29 CFR Part 1910.1450). Fed. Register.
11. Directive 2000/54/EC of the European Parliament and Council of 24 June 2020 on the protection of workers from risks related to exposure to biological agents at work.
12. Roche PC, Hsi ED. Immunohistochemistry-Principles and Advances. Manual of Clinical Laboratory Immunology, 6th edition. In: NR Rose, ed. ASM Press; 2002.

", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Principle", "Value": "CONFIRM anti-Desmin (DE-R-11) antibody binds to desmin in formalin-fixed, paraffinembedded (FFPE) tissue sections. This antibody can be visualized using OptiView DAB IHC Detection Kit (Cat. No. 760-700 / 06396500001) or ultraView Universal DAB Detection Kit (Cat. No. 760-500 / 05269806001). Refer to the respective method sheet for more information.", "Language": "en", "Country": "XG", "Code": "Principle" }, { "Name": "Product Purpose", "Value": "CONFIRM anti-Desmin (DE-R-11) is intended for laboratory use in the qualitative immunohistochemical detection of desmin by light microscopy in sections of formalin-fixed, paraffinembedded tissue stained on a BenchMark IHC/ISH instrument.

This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls. This antibody is intended for in vitro diagnostic (IVD) use.", "Language": "en", "Country": "XG", "Code": "Product Purpose" } ] } } ] }