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(Product)", "Value": "Upon receipt and when not in use, store at 2-8°C. Do not freeze.", "Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Intended Use", "Value": "Granzyme B Rabbit Polyclonal Primary Antibody is intended for laboratory use in the detection of the Granzyme B protein in formalin-fixed, paraffin-embedded tissue stained on VENTANA BenchMark IHC/ISH instruments. This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls. This antibody is intended for in vitro diagnostic (IVD) use.", "Language": "en", "Country": "XG", "Code": "Intended Use" }, { "Name": "Background Information", "Value": "Granzyme B is a serine protease expressed by cytotoxic T lymphocytes and natural killer (NK) cells and initiates apoptosis through multiple direct and indirect pathways.¹ Both neoplasm of lymphoid and non-lymphoid origin exhibit positivity for anti-Granzyme B.¹ Anti-Granzyme B has also been found to be useful in identifying natural killer/T-cell lymphoma, as well as anaplastic large cell lymphoma.^1-5

1. Kummer JA, et al. Localization and identification of granzymes A and B-expressing cells in normal human lymphoid tissue and peripheral blood. Clin Exp Immunol. 1995; 100:164- 72.
2. Oudejans JJ, et al. Granzyme B expression in Reed-Sternberg cells of Hodgkin’s disease. Am J Pathol. 1996; 148:233-40.
3. Oudejans JJ, et al. Activated cytotoxic T cells as prognostic marker in Hodgkin’s disease. Blood. 1997; 89:1376-82.
4. Kato N, et al. Neutrophil-rich anaplastic large cell lymphoma presenting in the skin. Am J Dermatopathol. 2003; 25:142-7.
5. Liu J, et al. Nasal natural killer/T cell lymphoma with cutaneous involvement: case report and Chinese literature review reported in China mainland. J Dermatol. 2003; 30:735-41.", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Content", "Value": "One dispenser of this antibody contains sufficient prediluted reagent for 50 tests.", "Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Principle", "Value": "Granzyme B Rabbit Polyclonal Antibody (this antibody) may be used as the primary antibody for immunohistochemical staining of formalin-fixed, paraffin-embedded tissue sections. In general, immunohistochemical staining allows the visualization of antigens via the sequential application of a specific antibody (primary antibody) to the antigen, a secondary antibody (link antibody) to the primary antibody, an enzyme complex and a chromogenic substrate with interposed washing steps. The enzymatic activation of the chromogen results in a visible reaction product at the antigen site. The specimen may then be counterstained and a coverslip applied. Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with a particular antigen.

This antibody is optimally diluted to be compatible with VENTANA detection kits and BenchMark IHC/ISH instruments. Refer to the Tables in the Instructions for Use section for recommended staining protocols. Each step in the staining protocol includes incubation for a precise time at a specific temperature. At the end of each incubation step, the sections are rinsed by the BenchMark IHC/ISH instruments to stop the reaction and remove unbound material that would hinder the desired reaction in subsequent steps. To minimize evaporation of the aqueous reagents from the specimen-containing slide, a coverslip solution is applied in the slide stainer. For more detailed information on instrument operation, refer to the appropriate BenchMark IHC/ISH instruments Operator’s Manual.", "Language": "en", "Country": "XG", "Code": "Principle" }, { "Name": "Product Purpose", "Value": "Granzyme B Rabbit Polyclonal Primary Antibody is intended for laboratory use in the detection of the Granzyme B protein in formalin-fixed, paraffin-embedded tissue stained on VENTANA BenchMark IHC/ISH instruments. This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls. This antibody is intended for in vitro diagnostic (IVD) use.", "Language": "en", "Country": "XG", "Code": "Product Purpose" } ] } } ] }