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Do not freeze.", "Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Intended Use", "Value": "Inhibin, alpha (MRQ-63) Rabbit Monoclonal Antibody is intended for laboratory use in the detection of the Inhibin, alpha protein in formalin-fixed, paraffin-embedded human tissue stained in qualitative immunohistochemistry (IHC) on BenchMark IHC/ISH instruments. This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls. This antibody is intended for in vitro diagnostic (IVD) use.", "Language": "en", "Country": "XG", "Code": "Intended Use" }, { "Name": "Content", "Value": "One dispenser of this antibody contains sufficient prediluted reagent for 50 tests.", "Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Background Information", "Value": "Inhibin is a peptide hormone that inhibits FSH secretion from the pituitary.^1-2 Inhibin is a dimer that consists of an alpha and beta subunit.^1-2 In normal tissue, anti-inhibin alpha labels granulosa cells of the ovary, sertoli and leydig cells of the testis, and the zona reticularis of the adrenal cortex.² Anti-inhibin alpha has demonstrated utility in the identification of sex cord stromal tumors and adrenal cortical tumors.^3-9

1. Munro LM, et al. The expression of inhibin/activin subunits in the human adrenal cortex and its tumours. J Endocrinol. 1999; 161:341-7.
2. McCluggage WG, et al. Immunohistochemical staining of normal, hyperplastic, and neoplastic adrenal cortex with a monoclonal antibody against alpha inhibin. J Clin Pathol. 1998; 51:114-6.
3. Stewart CJ, et al. Diagnostic value of inhibin immunoreactivity in ovarian gonadal stromal tumours and their histological mimics. Histopathology. 1997; 31:67-74.
4. Yamashita K, et al. Production of inhibin A and inhibin B in human ovarian sex cord stromal tumors. Am J Obstet Gynecol. 1997; 177:1450-7.
5. McCluggage WG, et al. Immunohistochemical study of testicular sex cord-stromal tumors, including staining with anti-inhibin antibody. Am J Surg Pathol. 1998; 22:615-9.
6. Kommoss F, et al. Inhibin expression in ovarian tumors and tumor-like lesions: an immunohistochemical study. Mod Pathol. 1998; 11:656-64.
7. Iczkowski KA, et al. Inhibin A is a sensitive and specific marker for testicular sex cordstromal tumors. Mod Pathol. 1998; 11:774-9.
8. Guerrieri C, et al. Ovarian endometrioid carcinomas simulating sex cord-stromal tumors: a study using inhibin and cytokeratin 7. Int J Gynecol Pathol. 1998; 17:266-71.
9. McCluggage WG. Recent advances in immunohistochemistry in the diagnosis of ovarian neoplasms. J Clin Pathol. 2000; 53:327-34.", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Principle", "Value": "Inhibin, alpha (MRQ-63) Rabbit Monoclonal Primary Antibody (this antibody) may be used as the primary antibody for immunohistochemical staining of formalin-fixed, paraffinembedded tissue sections. In general, immunohistochemical staining allows the visualization of antigens via the sequential application of a specific antibody (primary antibody) to the antigen, a secondary antibody (link antibody) to the primary antibody, an enzyme complex and a chromogenic substrate with interposed washing steps. The enzymatic activation of the chromogen results in a visible reaction product at the antigen site. The specimen may then be counterstained and a coverslip applied. Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with a particular antigen.

This antibody is optimally diluted to be compatible with VENTANA detection kits and BenchMark IHC/ISH instruments. Refer to the Tables in the Instructions for Use section for recommended staining protocols. Each step in the staining protocol includes incubation for a precise time at a specifi c temperature. At the end of each incubation step, the sections are rinsed by the BenchMark IHC/ISH instruments to stop the reaction and remove unbound material that would hinder the desired reaction in subsequent steps. To minimize evaporation of the aqueous reagents from the specimen-containing slide, a coverslip solution is applied in the slide stainer. For more detailed information on instrument operation, refer to the appropriate BenchMark IHC/ISH instruments Operator’s Manual.", "Language": "en", "Country": "XG", "Code": "Principle" }, { "Name": "Product Purpose", "Value": "Inhibin, alpha (MRQ-63) Rabbit Monoclonal Antibody is intended for laboratory use in the detection of the Inhibin, alpha protein in formalin-fixed, paraffin-embedded human tissue stained in qualitative immunohistochemistry (IHC) on BenchMark IHC/ISH instruments. This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls. This antibody is intended for in vitro diagnostic (IVD) use.", "Language": "en", "Country": "XG", "Code": "Product Purpose" } ] } } ] }