{
"ProductData": {
"ID": "RTD001007",
"ProductType": "Others",
"BrandName": "ISH Protease 2",
"ProductNameAddition": "",
"RegulatoryDisclaimer1": "For in vitro diagnostic use.",
"DisclaimerGroup1": "IVD",
"RegulatoryDisclaimer2": null,
"DisclaimerGroup2": null,
"RegulatoryDisclaimer3": null,
"SampleType": [
"Formalin-Fixed Paraffin-Embedded Tissue (FFPET)"
],
"LicenseDisclaimers": [
],
"RelatedLinks": "",
"Clone": "",
"ControlTissue": [
""
],
"ISOtypes": "",
"Species": [
""
],
"StainLocalization": [
""
],
"ProductNameGlobal": "ISH Protease 2"
},
"ProductImageDetails": {
"ImagePath": "https://pim-media.roche.com/Images/Article_05273323001_im_en.png",
"ImageType": "Image main"
},
"Product2Taxonomy": {
"Product2TaxonomyReferences": [
{
"StructureSystemIdentifier": "Product_Grouping",
"StructureSystemName": "Product Grouping",
"NodeID": "05-0027",
"StructureNodeStatus": "Active",
"NodeName": "Research Reagents Ancillaries"
},
{
"StructureSystemIdentifier": "Product_Grouping",
"StructureSystemName": "Product Grouping",
"NodeID": "05-0019",
"StructureNodeStatus": "Active",
"NodeName": "ISH Enzymes"
},
{
"StructureSystemIdentifier": "OWP_Product_Types",
"StructureSystemName": "Product Types",
"NodeID": "20-000-00",
"StructureNodeStatus": "Active",
"NodeName": "Assays Reagents and Strips"
},
{
"StructureSystemIdentifier": "OWP_Techniques",
"StructureSystemName": "Techniques",
"NodeID": "075-00",
"StructureNodeStatus": "Active",
"NodeName": "In situ Hybridization (ISH)"
},
{
"StructureSystemIdentifier": "Lab_Type",
"StructureSystemName": "Lab Types",
"NodeID": "080-00",
"StructureNodeStatus": "Active",
"NodeName": "Pathology Lab"
},
{
"StructureSystemIdentifier": "Product_Solutions",
"StructureSystemName": "Product Solutions",
"NodeID": "010",
"StructureNodeStatus": "Active",
"NodeName": "Histopathology"
},
{
"StructureSystemIdentifier": "Applications",
"StructureSystemName": "Applications",
"NodeID": "99-00-00",
"StructureNodeStatus": "Inactive",
"NodeName": ""
},
{
"StructureSystemIdentifier": "Pathogens",
"StructureSystemName": "Pathogens",
"NodeID": "99-00-00",
"StructureNodeStatus": "Inactive",
"NodeName": ""
},
{
"StructureSystemIdentifier": "Health_Topics",
"StructureSystemName": "Health Topics",
"NodeID": "99-00-00",
"StructureNodeStatus": "Inactive",
"NodeName": ""
},
{
"StructureSystemIdentifier": "Disease_Areas",
"StructureSystemName": "Disease Areas",
"NodeID": "99-00-00",
"StructureNodeStatus": "Inactive",
"NodeName": ""
},
{
"StructureSystemIdentifier": "OWP_Family",
"StructureSystemName": "Product Families",
"NodeID": "080",
"StructureNodeStatus": "Active",
"NodeName": "BenchMark"
}
]
},
"Product2Materials": {
"P2MaterialReferences": [
{
"MaterialNum": "05273323001",
"MaterialDescription": "ISH PROTEASE 2",
"RegisteredProductName": "ISH Protease 2",
"GTIN": "04015630971879",
"ProductCategoryText": "Reagents, kits",
"OldMaterialNumber": "780-4148",
"PackSizePIM360": "200 tests",
"PackSizeDescPIM360": "Not Available",
"MaterialAnnotation": "",
"ReadyForUse": "true",
"OrderInformation": ""
}
]
},
"Product2Products": {
"Product2ProductReference": [
{
"ProductID": "INS_2099",
"BrandName": "BenchMark ULTRA",
"ProductNameAddition": "",
"ReferenceType": "Instrument",
"Classification": [
{
"IdentifierofStructureSystem": "1",
"NameofStructureSystem": "GPCH",
"StructureNodeID": "2300",
"StructureGroupPath": "Histology->Systems / Digital Products->Advanced Staining->BenchMark ULTRA",
"StructureGroupName": "BenchMark ULTRA",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Product_Types",
"NameofStructureSystem": "Product Types",
"StructureNodeID": "10-000-00",
"StructureGroupPath": "Analyzer Instruments and Systems",
"StructureGroupName": "Analyzer Instruments and Systems",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Family",
"NameofStructureSystem": "Product Families",
"StructureNodeID": "080",
"StructureGroupPath": "BenchMark",
"StructureGroupName": "BenchMark",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Lab_Type",
"NameofStructureSystem": "Lab Types",
"StructureNodeID": "080-00",
"StructureGroupPath": "Pathology Lab",
"StructureGroupName": "Pathology Lab",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Product_Solutions",
"NameofStructureSystem": "Product Solutions",
"StructureNodeID": "010",
"StructureGroupPath": "Histopathology",
"StructureGroupName": "Histopathology",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Techniques",
"NameofStructureSystem": "Techniques",
"StructureNodeID": "073-00",
"StructureGroupPath": "Immunohistochemistry (IHC)",
"StructureGroupName": "Immunohistochemistry (IHC)",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Techniques",
"NameofStructureSystem": "Techniques",
"StructureNodeID": "075-00",
"StructureGroupPath": "In situ Hybridization (ISH)",
"StructureGroupName": "In situ Hybridization (ISH)",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Applications",
"NameofStructureSystem": "Applications",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Disease_Areas",
"NameofStructureSystem": "Disease Areas",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Pathogens",
"NameofStructureSystem": "Pathogens",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Health_Topics",
"NameofStructureSystem": "Health Topics",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
}
]
},
{
"ProductID": "INS_2580",
"BrandName": "BenchMark GX",
"ProductNameAddition": "",
"ReferenceType": "Instrument",
"Classification": [
{
"IdentifierofStructureSystem": "1",
"NameofStructureSystem": "GPCH",
"StructureNodeID": "6151",
"StructureGroupPath": "Histology->Systems / Digital Products->Advanced Staining->BenchMark GX",
"StructureGroupName": "BenchMark GX",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Product_Types",
"NameofStructureSystem": "Product Types",
"StructureNodeID": "10-000-00",
"StructureGroupPath": "Analyzer Instruments and Systems",
"StructureGroupName": "Analyzer Instruments and Systems",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Family",
"NameofStructureSystem": "Product Families",
"StructureNodeID": "080",
"StructureGroupPath": "BenchMark",
"StructureGroupName": "BenchMark",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Lab_Type",
"NameofStructureSystem": "Lab Types",
"StructureNodeID": "080-00",
"StructureGroupPath": "Pathology Lab",
"StructureGroupName": "Pathology Lab",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Product_Solutions",
"NameofStructureSystem": "Product Solutions",
"StructureNodeID": "010",
"StructureGroupPath": "Histopathology",
"StructureGroupName": "Histopathology",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Techniques",
"NameofStructureSystem": "Techniques",
"StructureNodeID": "999-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Applications",
"NameofStructureSystem": "Applications",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Disease_Areas",
"NameofStructureSystem": "Disease Areas",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Pathogens",
"NameofStructureSystem": "Pathogens",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Health_Topics",
"NameofStructureSystem": "Health Topics",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
}
]
}
]
},
"ProductSpec": [
{
"ProductSpecVariant": {
"Chapters": [
{
"Name": "Storage Conditions (Product)",
"Value": "Upon receipt and when not in use, store at 2-8°C. Do not freeze.",
"Language": "en",
"Country": "XG",
"Code": "Storage Conditions (Product)"
},
{
"Name": "Content",
"Value": "ISH Protease 2 contains sufficient reagent for 200 tests.
One 20 mL dispenser ISH Protease 2 contains approximately 0.1 mg/mL of alkaline protease in a Tris-based enzyme stabilizing solution containing sodium azide.",
"Language": "en",
"Country": "XG",
"Code": "Content"
},
{
"Name": "Principle",
"Value": "ISH Protease 2 is used with probes, accessory reagents and the BenchMark IHC/ISH instrument to achieve appropriate in situ hybridization (ISH) staining.
Enzymatic digestion using ISH Protease 2 removes cross-linking of proteins to ensure that the probe of interest reaches its target DNA or RNA sequence.1 ISH Protease 2 is a medium activity enzyme formulation that cleaves proteins in the formalin-fixed, paraffinembedded (FFPE) tissue section, exposing the target nucleic acid sequence for hybridization by the probe. Digestion is followed by probe application and is used in combination with VENTANA detection kits. ISH Protease 2 may be used for target nucleic acid sequences requiring moderate digestion for optimal staining.
1. Beesley JE. Immunocytochemistry and In Situ Hybridization in the Biomedical Sciences. Boston: Birkhäuser, 2001.",
"Language": "en",
"Country": "XG",
"Code": "Principle"
},
{
"Name": "Intended Use",
"Value": "ISH Protease 2 is intended for enzymatic digestion of formalin-fixed, paraffin-embedded tissue sections, or whole cell preparations on a BenchMark IHC/ISH instrument. This reagent removes protein that surrounds the target nucleic acid sequences of interest during in situ hybridization applications.
This reagent is intended for in vitro diagnostic (IVD) use.
Enzymatic digestion using VENTANA ISH Protease 2 removes cross-linking of proteins to ensure that the probe of interest reaches its target DNA or RNA sequence.1 Digestion is followed by probe application and is used in combination with VENTANA detection kits.
1. Beesley JE. Immunocytochemistry and In Situ Hybridization in the Biomedical Sciences. Boston: Birkhäuser, 2001.",
"Language": "en",
"Country": "XG",
"Code": "Intended Use"
},
{
"Name": "Product Purpose",
"Value": "ISH Protease 2 is intended for enzymatic digestion of formalin-fixed, paraffin-embedded tissue sections, or whole cell preparations on a BenchMark IHC/ISH instrument. This reagent removes protein that surrounds the target nucleic acid sequences of interest during in situ hybridization applications.
This reagent is intended for in vitro diagnostic (IVD) use.
Enzymatic digestion using VENTANA ISH Protease 2 removes cross-linking of proteins to ensure that the probe of interest reaches its target DNA or RNA sequence.1 Digestion is followed by probe application and is used in combination with VENTANA detection kits.
1. Beesley JE. Immunocytochemistry and In Situ Hybridization in the Biomedical Sciences. Boston: Birkhäuser, 2001.",
"Language": "en",
"Country": "XG",
"Code": "Product Purpose"
}
]
}
}
]
}
