For in vitro diagnostic use. Nucleus Others MLH1 M1 MMR IHC Panel VENTANA IVD Colorectal Carcinoma VENTANA® anti-MLH1 (M1) Mouse Monoclonal Primary Antibody RTD001199 For use with the VENTANA MMR IHC Panel Mouse M1 09498460001 VENTANA MLH1 (M1) MM PAB-US Export J VENTANA MLH1 (M1) MM PAB 07613336200193 Reagents, kits 780-7140 Not Available Not Available 08033668001 MLH1 (M1) MM PAB-US Export VENTANA anti-mLH1 (M1) Mouse Monoclonal Primary Antibody 07613336119358 Reagents, kits 760-5091 50 tests Not Available true 09605584001 MLH1 (M1) MM PAB W US Export MLH1 (M1) MM PAB 07613336206171 Reagents, kits 730-7159 Not Available Not Available VENTANA anti-MLH1 (M1) Mouse Monoclonal Primary Antibody (VENTANA anti-MLH1 (M1) antibody) is intended for the qualitative detection of MLH1 protein in formalin-fixed, paraffinembedded tissue sections. VENTANA anti-MLH1 (M1) antibody is ready to use on BenchMark IHC/ISH instruments with the OptiView DAB IHC Detection Kit and ancillary reagents.VENTANA anti-MLH1 (M1) antibody is part of the VENTANA MMR IHC Panel which includes VENTANA anti-PMS2 (A16-4) Mouse Monoclonal Primary Antibody, VENTANA anti-MSH2 (G219- 1129) Mouse Monoclonal Primary Antibody, VENTANA anti-MSH6 (SP93) Rabbit Monoclonal Primary Antibody and VENTANA anti-BRAF V600E (VE1) Mouse Monoclonal Primary Antibody. The VENTANA MMR IHC Panel is indicated for the detection of mismatch repair protein deficiency as a test for the identification of individuals at risk for Lynch syndrome in patients diagnosed with colorectal cancer (CRC), and, with BRAF V600E status, as an aid to differentiate between sporadic and probable Lynch syndrome CRC in the absence of MLH1 protein expression.This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls. This antibody is intended for in vitro diagnostic (IVD) use. en VENTANA anti-MLH1 (M1) antibody binds to MLH1 protein in formalin-fixed, paraffinembedded (FFPE) tissue sections. The antibody can be localized using a haptenated secondary antibody followed by a multimer anti-hapten-HRP conjugate (OptiView DAB IHC Detection Kit). The specific antibody-enzyme complex is then visualized with a precipitating enzyme reaction product. Each step is incubated for a precise time and temperature. At the end of each incubation step, each BenchMark IHC/ISH instrument washes the sections to stop the reaction and to remove unbound material that would Figure 1. VENTANA anti-MLH1 (M1) Mouse Monoclonal Primary Antibody staining with Intact (top) or Loss (bottom) of expression in colon cancer tissue. 2024-01-02 2 / 10 1015763EN Rev F FT0700-410u hinder the desired reaction in subsequent steps. It also applies ULTRA LCS (Predilute) or LCS (Predilute) which minimizes evaporation of the aqueous reagents from the specimen slide. en