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Do not freeze.", "Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Intended Use", "Value": "MUC5AC (MRQ-19) Mouse Monoclonal Primary Antibody is intended for laboratory use in the detection of the MUC5AC protein in formalin-fixed, paraffin-embedded human tissue stained in qualitative immunohistochemistry (IHC) on BenchMark IHC/ISH instruments. This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls. This antibody is intended for in vitro diagnostic (IVD) use.", "Language": "en", "Country": "XG", "Code": "Intended Use" }, { "Name": "Background Information", "Value": "MUC5AC is a secretory mucin that is part of a family of at least 14 high molecular weight glycoproteins made by many epithelial tissues.¹ MUC5AC is preferentially expressed in non-neoplastic gastric tissue and benign respiratory tract tissue.¹ During neplastic transformation, mucin expression may be altered within these tissues leading to particular patterns of expression.¹ Cytoplasmic expression of MUC5AC can be seen in carcinomas of the gastrointestinal tract, particularly those of esophagus and stomach, as well as the pancreatobiliary tract includng cholangiocarcinomas.¹ Other tumors expressing MUC5AC include carcinomas of the endocervix endometrium and lung.¹ MUC5AC immunoreactivity may also be seen in extramammary Paget’s disease but it is not expressed in mammary paget’s disease.² Use of a panel of mucins including MUC1/MUC2/MUC5AC may be helpful with differential diagnosis in particular neoplastic settings.¹

1. Lau SK, et al. Differential expression of MUC1, MUC2, and MUC5AC in carcinomas of various sites: an immunohistochemical study. Am J Clin Pathol. 2004; 122:61-9.
2. Kuan, S. et al. Differential Expression of Mucin Genes in Mammary and Extramammary Paget’s Disease. Am J Surg Pathol. 2001; 25:1469-77.", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Content", "Value": "One dispenser of this antibody contains sufficient prediluted reagent for 50 tests.", "Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Principle", "Value": "MUC5AC (MRQ-19) Mouse Monoclonal Antibody (this antibody) may be used as the primary antibody for immunohistochemical staining of formalin-fixed, paraffin-embedded tissue sections. In general, immunohistochemical staining allows the visualization of antigens via the sequential application of a specific antibody (primary antibody) to the antigen, a secondary antibody (link antibody) to the primary antibody, an enzyme complex and a chromogenic substrate with interposed washing steps. The enzymatic activation of the chromogen results in a visible reaction product at the antigen site. The specimen may then be counterstained and a coverslip applied. Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with a particular antigen.

This antibody is optimally diluted to be compatible with VENTANA detection kits and BenchMark IHC/ISH instruments. Refer to the Tables in the Instructions for Use section for recommended staining protocols. Each step in the staining protocol includes incubation for a precise time at a specifi c temperature. At the end of each incubation step, the sections are rinsed by the BenchMark IHC/ISH instruments to stop the reaction and remove unbound material that would hinder the desired reaction in subsequent steps. To minimize evaporation of the aqueous reagents from the specimen-containing slide, a coverslip solution is applied in the slide stainer. For more detailed information on instrument operation, refer to the appropriate BenchMark IHC/ISH instruments Operator’s Manual.", "Language": "en", "Country": "XG", "Code": "Principle" }, { "Name": "Product Purpose", "Value": "MUC5AC (MRQ-19) Mouse Monoclonal Primary Antibody is intended for laboratory use in the detection of the MUC5AC protein in formalin-fixed, paraffin-embedded human tissue stained in qualitative immunohistochemistry (IHC) on BenchMark IHC/ISH instruments. This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls. This antibody is intended for in vitro diagnostic (IVD) use.", "Language": "en", "Country": "XG", "Code": "Product Purpose" } ] } } ] }