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"Value": "p57 is a human tumor suppressor gene encoded on the 11p15.5 chromosomal sequence. Anti-p57 has been used as an aid in discriminating complete hydatidiform mole (CHM) (no nuclear labeling of cytotrophoblasts or stromal cells) from partial hydatidiform mole (PHM) (nuclear staining of both cytotrophoblasts and stromal cells) and hydropic abortion. In normal placenta, cytotrophoblast, intermediate trophoblast and decidual cells, and stromal cells are labeled with this antibody. Intervillous trophoblastic islands demonstrate nuclear labeling in all entities and serve as an internal control.
1-61. Kihara M, et al. Genetic origin and imprinting in hydatidiform moles. Comparison betweenDNA polymorphism analysis and immunoreactivity of p57Kip2. J Reprod Med. 2005;50:307-12.
2. Romaguera RL, et al. Molar gestations and hydropic abortions differentiated by p57immunostaining. Fetal Pediatr Pathol. 2004; 23:181-90.
3. Marjoniemi VM. Immunohistochemistry in gynaecological pathology: a review. Pathology.2004; 36:109-19.
4. Jun SY, et al. p57Kip2 is useful in the classification and differential diagnosis of completeand partial hydatidiform moles. Histopathology. 2003; 43:17-25.
5. Lund, Helle et al. p57 in Hydatidiform Moles: Evaluation of Antibodies and Expression in Various Cell Types. Appl Immunohistochem Mol Morphol. 2020; 28:694-701.
6. Ronnett BM. Hydatidiform Moles: Ancillary Techniques to Refine Diagnosis. Arch Pathol Lab Med. 2018; 142:1485-1502.",
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