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Do not freeze.", "Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Content", "Value": "One dispenser of this antibody contains sufficient prediluted reagent for 50 tests.", "Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Background Information", "Value": "p57 is a human tumor suppressor gene encoded on the 11p15.5 chromosomal sequence. Anti-p57 has been used as an aid in discriminating complete hydatidiform mole (CHM) (no nuclear labeling of cytotrophoblasts or stromal cells) from partial hydatidiform mole (PHM) (nuclear staining of both cytotrophoblasts and stromal cells) and hydropic abortion. In normal placenta, cytotrophoblast, intermediate trophoblast and decidual cells, and stromal cells are labeled with this antibody. Intervillous trophoblastic islands demonstrate nuclear labeling in all entities and serve as an internal control.1-6

1. Kihara M, et al. Genetic origin and imprinting in hydatidiform moles. Comparison betweenDNA polymorphism analysis and immunoreactivity of p57Kip2. J Reprod Med. 2005;50:307-12.
2. Romaguera RL, et al. Molar gestations and hydropic abortions differentiated by p57immunostaining. Fetal Pediatr Pathol. 2004; 23:181-90.
3. Marjoniemi VM. Immunohistochemistry in gynaecological pathology: a review. Pathology.2004; 36:109-19.
4. Jun SY, et al. p57Kip2 is useful in the classification and differential diagnosis of completeand partial hydatidiform moles. Histopathology. 2003; 43:17-25.
5. Lund, Helle et al. p57 in Hydatidiform Moles: Evaluation of Antibodies and Expression in Various Cell Types. Appl Immunohistochem Mol Morphol. 2020; 28:694-701.
6. Ronnett BM. Hydatidiform Moles: Ancillary Techniques to Refine Diagnosis. Arch Pathol Lab Med. 2018; 142:1485-1502.", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Intended Use", "Value": "p57Kip2 (Kp10) Mouse Monoclonal Primary Antibody is intended for laboratory use in
the detection of the p57Kip2 protein in formalin-fixed, paraffin-embedded human tissue
stained in qualitative immunohistochemistry (IHC) on BenchMark IHC/ISH instruments. This
product should be interpreted by a qualified pathologist in conjunction with histological
examination, relevant clinical information, and proper controls. This antibody is intended for
in vitro diagnostic (IVD) use.", "Language": "en", "Country": "XG", "Code": "Intended Use" }, { "Name": "Principle", "Value": "anti-p57Kip2 (Kp10) Mouse Monoclonal Primary Antibody (this antibody) may be used as the primary antibody for immunohistochemical staining of formalin-fixed, paraffin-embedded tissue sections. In general, immunohistochemical staining allows the visualization of antigens via the sequential application of a specific antibody (primary antibody) to the antigen, a secondary antibody (link antibody) to the primary antibody, an enzyme complex and a chromogenic substrate with interposed washing steps. The enzymatic activation of the chromogen results in a visible reaction product at the antigen site. The specimen may then be counterstained and a coverslip applied. Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with a particular antigen.

This antibody is optimally diluted to be compatible with VENTANA detection kits and BenchMark IHC/ISH instruments. Refer to the Tables in the Instructions for Use section for recommended staining protocols. Each step in the staining protocol includes incubation for a precise time at a specifi c temperature. At the end of each incubation step, the sections are rinsed by the BenchMark IHC/ISH instruments to stop the reaction and remove unbound material that would hinder the desired reaction in subsequent steps. To minimize evaporation of the aqueous reagents from the specimen-containing slide, a coverslip solution is applied in the slide stainer. For more detailed information on instrument operation, refer to the appropriate BenchMark IHC/ISH instruments Operator’s Manual.", "Language": "en", "Country": "XG", "Code": "Principle" }, { "Name": "Product Purpose", "Value": "p57Kip2 (Kp10) Mouse Monoclonal Primary Antibody is intended for laboratory use in
the detection of the p57Kip2 protein in formalin-fixed, paraffin-embedded human tissue
stained in qualitative immunohistochemistry (IHC) on BenchMark IHC/ISH instruments. This
product should be interpreted by a qualified pathologist in conjunction with histological
examination, relevant clinical information, and proper controls. This antibody is intended for
in vitro diagnostic (IVD) use.", "Language": "en", "Country": "XG", "Code": "Product Purpose" } ] } } ] }

anti-p57Kip2 (Kp10) Mouse Monoclonal Primary Antibody

IVD For in vitro diagnostic use.
anti-p57<sup>Kip2</sup> (Kp10) Mouse Monoclonal Primary Antibody

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Detailed Specifications

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