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"Techniques", "StructureNodeID": "073-00", "StructureGroupPath": "Immunohistochemistry (IHC)", "StructureGroupName": "Immunohistochemistry (IHC)", "StructureNodeStatus": "Active" }, { "IdentifierofStructureSystem": "Applications", "NameofStructureSystem": "Applications", "StructureNodeID": "99-00-00", "StructureGroupPath": "", "StructureGroupName": "", "StructureNodeStatus": "Inactive" }, { "IdentifierofStructureSystem": "Pathogens", "NameofStructureSystem": "Pathogens", "StructureNodeID": "99-00-00", "StructureGroupPath": "", "StructureGroupName": "", "StructureNodeStatus": "Inactive" }, { "IdentifierofStructureSystem": "Disease_Areas", "NameofStructureSystem": "Disease Areas", "StructureNodeID": "99-00-00", "StructureGroupPath": "", "StructureGroupName": "", "StructureNodeStatus": "Inactive" }, { "IdentifierofStructureSystem": "Health_Topics", "NameofStructureSystem": "Health Topics", "StructureNodeID": "99-00-00", "StructureGroupPath": "", "StructureGroupName": "", "StructureNodeStatus": "Inactive" } ] } ] }, "ProductSpec": [ { "ProductSpecVariant": { "Chapters": [ { "Name": "Storage Conditions (Product)", "Value": "Upon receipt and when not in use, store at 2-8°C. Do not freeze.", "Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Content", "Value": "CONFIRM anti-PAX5 (SP34) antibody contains sufficient reagent for 50 tests.

One 5 mL dispenser of CONFIRM anti-PAX5 (SP34) antibody contains approximately 5 μg of a recombinant rabbit monoclonal antibody.
The antibody is diluted in Tris-HCI with carrier protein, and 0.10% ProClin 300, a preservative. Specific antibody concentration is approximately 1.0 μg/mL. There is no known nonspecific antibody reactivity observed in this product.", "Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Intended Use", "Value": "CONFIRM anti-PAX5 (SP34) Rabbit Monoclonal Primary Antibody is  intended for laboratory use in the qualitative immunohistochemical detection of PAX5 by light microscopy  in sections of formalin-fixed, paraffin-embedded tissue stained on a BenchMark IHC/ISH instrument. 

This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls.

This antibody is intended for in vitro diagnostic (IVD) use.", "Language": "en", "Country": "XG", "Code": "Intended Use" }, { "Name": "Background Information", "Value": "CONFIRM anti-PAX5 (SP34) Rabbit Monoclonal Primary Antibody (CONFIRM anti-PAX5 (SP34) antibody) is a rabbit monoclonal antibody directed against a synthetic peptide derived from the amino acid sequence within the C-terminus of human PAX5 protein. The PAX5 gene encodes for the B-cell-specific activator protein (BSAP), but PAX5 is the more commonly used term in diagnostic pathology literature.1,2 In the early stages of B cell development, PAX5 influences the expression of several B cell specific genes, which code for CD79, CD19 and CD20.2 PAX5 is expressed primarily in pro-, pre-, and mature B cells, but not in plasma cells.1,2,3 Aside from B cells, PAX5 is detected in the developing central nervous system and adult testis.1 PAX5 is also detected in neoplasms derived from B cells.1,2,3,4 PAX5 is a pan-B cell marker and expressed in the majority of B cell lymphomas without plasma cell differentiation.1,2,3,4 Plasma cell neoplasms, multiple myeloma, and plasmablastic lymphomas are typically negative when stained with PAX5.1,5 PAX5 expression is detected in a subset of Hodgkin lymphomas but absent in T- cell lymphomas.1,2,3,4
The detection of PAX5 by immunohistochemistry (IHC) with the CONFIRM anti-PAX5 (SP34) antibody may be used as an aid in the identification of normal and neoplastic B- cells and the classification of Hodgkin lymphomas. This antibody may be used as part of a panel of IHC studies. The staining pattern is nuclear.

1. O'Malley DP, Fedoriw Y, Grimm KE, et al. Immunohistology of Lymph Node and Lymph Node Neoplasms, 5th Edition. In: Dabbs DJ, ed. Diagnostic Immunohistochemistry. Elsevier 2019:160-202..
2. Cobaleda C. et al.(2007) Pax-5: the guardian of B-cell identity and function. Nat. Immunol. 8: 463-470.
3. Feldman, A.L. and Dogan, A. (2007) Diagnostic uses of Pax-5 Immunohistochemistry Adv. Anat. Path. 14:323-334.
4. Jensen, K.C. et al. (2007) The utility of Pax-5 immunohistochemistry in the diagnosis of undifferentiated malignant neoplasms Mod. Pathol. 20:871-877.
5. Mhawech-Fauceglia, P. et al.(2007) Pax-5 immunoexpression in various types of benign and malignant tumors: a high-throughput tissue microarray analysis. J. Clin. Pathol. 60:709-714.", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Principle", "Value": "CONFIRM anti-PAX5 (SP34) antibody binds to the PAX5 protein in formalin-fixed, paraffin-embedded (FFPE) tissue sections. This antibody can be visualized using ultraView Universal DAB Detection Kit (Cat. No. 760-500 / 05269806001). Refer to the ultraView Universal DAB Detection Kit method sheet for further information.", "Language": "en", "Country": "XG", "Code": "Principle" }, { "Name": "Product Purpose", "Value": "CONFIRM anti-PAX5 (SP34) Rabbit Monoclonal Primary Antibody is  intended for laboratory use in the qualitative immunohistochemical detection of PAX5 by light microscopy  in sections of formalin-fixed, paraffin-embedded tissue stained on a BenchMark IHC/ISH instrument. 

This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls.

This antibody is intended for in vitro diagnostic (IVD) use.", "Language": "en", "Country": "XG", "Code": "Product Purpose" } ] } } ] }

CONFIRM anti-PAX5 (SP34) Rabbit Monoclonal Primary Antibody

IVD For in vitro diagnostic use.
CONFIRM anti-PAX5 (SP34) Rabbit Monoclonal Primary Antibody

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