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Do not freeze.", "Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Intended Use", "Value": "PLAP (NB10) Mouse Monoclonal Primary Antibody is intended for laboratory use in the detection of the PLAP protein in formalin-fixed, paraffin-embedded human tissue stained in qualitative immunohistochemistry (IHC) on BenchMark IHC/ISH instruments. This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls. This antibody is intended for in vitro diagnostic (IVD) use", "Language": "en", "Country": "XG", "Code": "Intended Use" }, { "Name": "Content", "Value": "One dispenser of this antibody contains sufficient prediluted reagent for 50 tests.", "Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Background Information", "Value": "Placental Alkaline Phosphatase (PLAP) belongs to a family of four isozymes that are synthesized in primordial germ cells and in term placental syncytiotrophoblasts.1 Anti-PLAP may be useful in the identification of germ cell tumors.2-4

1. Fishman L, et al. Developmental phase-specific alkaline phosphatase isoenzymes of human placenta and their occurrence in human cancer. Cancer Res. 1976; 36:2268-73.
2. Stinghen ST, et al. Specific immunoassays for placental alkaline phosphatase as a tumor marker. J Biomed Biotechnol. 2006; 56087:1-8.
3. Ravenni N, et al. A human monoclonal antibody specific to placental alkaline phosphatase, a marker of ovarian cancer. MAbs. 2014; 6:86-94.
4. Jacobsen GK, et al. Placental alkaline phosphatase in testicular germ cell tumours and in carcinoma-in-situ of the testis. An immunohistochemical study. Acta Pathol Microbiol Immunol Scand A. 1984; 92:323-9.", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Principle", "Value": "PLAP (NB10) Mouse Monoclonal Antibody (this antibody) may be used as the primary\nantibody for immunohistochemical staining of formalin-fixed, paraffin-embedded tissue\nsections. In general, immunohistochemical staining allows the visualization of antigens\nvia the sequential application of a specific antibody (primary antibody) to the antigen, a\nsecondary antibody (link antibody) to the primary antibody, an enzyme complex and a\nchromogenic substrate with interposed washing steps. The enzymatic activation of the\nchromogen results in a visible reaction product at the antigen site. The specimen may then be\ncounterstained and a coverslip applied. Results are interpreted using a light microscope and\naid in the differential diagnosis of pathophysiological processes, which may or may not be\nassociated with a particular antigen.\n
\n
\nThis antibody is optimally diluted to be compatible with VENTANA detection kits and\nBenchMark IHC/ISH instruments. Refer to the Tables in the Instructions for Use section for\nrecommended staining protocols. Each step in the staining protocol includes incubation for\na precise time at a specific temperature. At the end of each incubation step, the sections are\nrinsed by the BenchMark IHC/ISH instruments to stop the reaction and remove unbound\nmaterial that would hinder the desired reaction in subsequent steps. To minimize evaporation\nof the aqueous reagents from the specimen-containing slide, a coverslip solution is applied\nin the slide stainer. For more detailed information on instrument operation, refer to the\nappropriate BenchMark IHC/ISH instruments Operator’s Manual.", "Language": "en", "Country": "XG", "Code": "Principle" }, { "Name": "Product Purpose", "Value": "PLAP (NB10) Mouse Monoclonal Primary Antibody is intended for laboratory use in the detection of the PLAP protein in formalin-fixed, paraffin-embedded human tissue stained in qualitative immunohistochemistry (IHC) on BenchMark IHC/ISH instruments. This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls. This antibody is intended for in vitro diagnostic (IVD) use", "Language": "en", "Country": "XG", "Code": "Product Purpose" } ] } } ] }

PLAP (NB10) Mouse Monoclonal Antibody

IVD For in vitro diagnostic use.
PLAP (NB10) Mouse Monoclonal Antibody

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