For in vitro diagnostic use. Others Protease 1 IVD Protease 1 RTD001097 05266688001 PROTEASE 1 Protease 1 04015630971138 Reagents, kits 760-2018 250 tests Not Available true Protease 1 is an endopeptidase (alkaline protease) of the serine protease family and cleaves proteins in the tissue section, allowing primary antibodies to recognize and bind epitope(s). The reagent is intended for enzymatic digestion of sections of routine formalin-fixed, paraffin-embedded tissue on a Benchmark IHC/ISH instrument.This reagent is intended for in vitro diagnostic (IVD) use. en Protease 1 is used with antibodies, accessory reagents and the BenchMark IHC/ISH instrument to achieve appropriate immunohistochemistry (IHC) staining.Enzymatic digestion of tissue with proteases prior to primary antibody application often increases immunoreactivity.1 Protease 1 is a high activity enzyme formulation that cleaves proteins in the formalin-fixed, paraffin-embedded (FFPE) tissue section, exposing the antigen for binding by the primary antibody. Digestion is followed by primary antibody application and is used in combination with VENTANA detection kits. Protease 1 may be used for antigens requiring extensive digestion for optimal staining.1. Brozman, M. Immunohistochemical analyses of formaldehyde and trypsin- or pepsin-treated material. Acta Histochem. 1978:63(2);251-560. en