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"Value": "Sal-like protein 4 (SALL4) is a zinc-finger transcription factor
1 that serves as a master regulator of embryonic pluripotency and is involved in processes associated with stem cell activities.
2 SALL4 expression in germ cells makes it a useful marker for germ cell tumors such as seminoma, embryonal carcinoma, yolk sac tumors and teratomas.
1 SALL4 expression is also seen in the spermatogonia of normal testis.
1. Miettinen M, et al. SALL4 expression in germ cell and non-germ cell tumors: a systematic immunohistochemical study of 3215 cases. Am J Surg Pathol. 2014; 38:410-20.
2. Yang J, et al. Genome-wide analysis reveals Sall4 to be a major regulator of pluripotency in murine-embryonic stem cells. PNAS. 2008; 105:19756-61.",
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